> AIDS Vaccines at the Crossroads includes the following sections:

The Past Year: Update, Analysis & Recommendations reviews the past year and provide an update and analysis on several key issues for the field including:

• The Global HIV/AIDS Vaccine Enterprise and what we can expect as it begins to implement its scientific plan.
• New directions in collaboration, including CHAVI, OCTAVE, PAVE and the forthcoming Gates Foundation grants.
• What the Adeno5 proof of concept trial and others to come mean for the field.
• The importance of making go/no-go decisions more quickly and accurately.
• How promising antibody and mucosal immunity research may accelerate the development of new candidates into the pipeline.
• The increasing importance of developing world research collaborations.

> Download a PDF of The Past Year: Update, Analysis & Recommendations

Get Enterprising is an open letter to the soon-to-be-named executive director of the Global HIV/AIDS Vaccine Enterprise, detailing the eight key issues we believe the new director should tackle from the first day on the job. These include:

• Communicate frequently and transparently. Reach out to all of those who are working with and interested in the field.
• Set policies for sharing and coordination of data and technology. Put publicly available policies and procedures into place to ensure full and fair sharing of data and technology.
• Ensure the ability to take risks. Seek out and foster innovation in basic research, vaccine development, community advocacy, and regulatory and intellectual property issues and other areas.
• Bring new investigators into the search. Ensure that there are adequate incentives for young researchers (from developed and developing countries) to enter the field.
• Make the Enterprise truly global. Seize the opportunity to be a truly global leader and reach out to all who have contributions to make.
• Involve civil society in a meaningful way. Work to incorporate civil society’s valuable insights into the framework of the Enterprise.
• Take on the politics and ethics of clinical trials. The Enterprise cannot focus only on scientific bottlenecks and leave the political and ethical bottlenecks to resolve themselves.
• Establish realistic milestones and a process for monitoring progress. Within the first six months on the job, you should articulate a set of milestones for the Enterprise to achieve over the next two years.

> Download a PDF of Get Enterprising

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