AIDS Vaccine Advocacy Coalition: Timeline

**HIV Prevention Research: A Comprehensive Timeline**

The timeline below summarizes the major HIV prevention research trials that are underway today. The research spans multiple strategies: from AIDS vaccines, to microbicides, to male circumcision, to behavioral interventions. Data from each of these studies has the impact to add to or change approaches to HIV prevention worldwide. And these studies will also have an impact on each other - no single HIV prevention strategy or field of research exists in a vacuum. This is a tool for advocates interested in learning more, making connections, and becoming involved in planning for a complex and exciting future.

Click here to download a printable PDF version of the timeline (update coming soon)

Click here to download a PDF of the trials pop-up text

HIV PREVENTION RESEARCH: A COMPREHENSIVE TIMELINE *

KEY

Vaccine

Microbicide

Partner Treatment

HSV-2 Treatment/Suppression

Pre-Exposure Prophylaxis (PrEP)

Behavioral

Female-Initiated Barrier Method

Male Circumcision

2007	2008	2009	2010	2011	2012	2013
FHI Phase III trial of the vaginal microbicide Cellulose Sulfate gel for the prevention of HIV infection in women [Trial stopped early, January 2007] More...	Phase III trial of the vaginal microbicide Carraguard for the prevention of HIV infection in women [Results announced, February 2008] More...	Large-scale trial of a once-daily dose of Truvada® to prevent HIV infection in heterosexual men and women More...	Large-scale trial of a once-daily dose of Truvada® to prevent HIV infection in high-risk HIV-negative men who have sex with men More...	Phase III trial of community mobilization, mobile testing, same-day results, and post-test support for HIV More...		Phase III trial to determine the effectiveness of two antiretroviral treatment strategies in preventing the sexual transmission of HIV in HIV-serodiscordant couples More...
CONRAD Phase III trial of the vaginal microbicide Cellulose Sulfate gel for the prevention of HIV infection in women [Trial stopped early, January 2007] More...	Study of different risk-reduction interventions for HIV vaccine trials (Project UNITY) More...	Phase II/IIb trial of the vaginal microbicides BufferGel and 0.5% PRO2000/5 Gel (P) for the prevention of HIV infection in women More...	Phase II trial of the vaginal microbicide Tenofovir gel for the prevention of HIV infection in women More...
Phase III trial of the female diaphragm to prevent HIV infection in women [Results announced July 2007.] More...	Large-scale trial of a once-daily dose of tenofovir to prevent HIV infection in injecting drug users More...	Phase III trial of a prime-boost (ALVAC-AIDSVAX) combination preventive HIV vaccine More...
Test-of-concept trial of Merck's adenovirus preventive HIV vaccine candidate (Step study) [Trial stopped early, September 2007] More...	Phase III trial of HSV-2 suppression in serodiscordant couples More...	Phase III trial of the vaginal microbicide PRO 2000 for the prevention of HIV infection in women More...
Test-of-concept trial of Merck's adenovirus preventive HIV vaccine candidate (Phambili) [Trial stopped early, September 2007] More...	Phase III trial of acyclovir for the reduction of HIV infection in high-risk, HIV-negative, HSV-2 seropositive individuals [Results announced, February 2008] More...	Phase II trial to test the clinical and behavioral safety of a once-daily dose of tenofovir among HIV-negative men who have sex with men More...
	Large-scale trial to evaluate the safety of male circumcision and its potential protective effect for HIV-negative female partners of HIV-positive circumcised males [Results announced February 2008.] More...

*The trial end-dates listed in this table are estimates. Due to the nature of clinical trials the actual dates may change. We will continue to monitor the trials' progress and will update the timeline accordingly. If you have any questions regarding the information presented here please contact us.

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