P-Values

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

At P-Values, you’ll find updates, perspective, insights and information from staff and partners working on the frontlines of research, advocacy and implementation. P-value is a statistical term for the probability that a trial result is reliable and not the outcome of chance. 

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Global Health Watch: Health Policy Decisions Reversed, FY26 US Global Health Funding, America First MoUs Scrutinized & LEN for PrEP Advances

The US foreign assistance budget, if enacted, would restore some global health funds in a broader context of uncertainty, as US bilateral “America First” health MoUs advance without transparent plans for implementation or accountability. At the same time, abrupt reversals by the US Department of Health and Human Services of troubling health policy decisions underscore the Administration’s instability. Meanwhile, momentum around lenacapavir continues, recently approved by Brazil and with additional funding from Unitaid to reach more populations in South Africa and Zambia.

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Global Health Watch: Assault on US vaccine policy, contradictions in HPV and HIV vaccine science; 14 countries sign America First MOUs

The assault on vaccine policy and confidence intensified this week as the US overhauled its childhood immunization schedule. Beyond the US, 14 countries have now signed bilateral health agreements with the US under the America First Global Health Strategy. At the same time, the US President signed a new executive order withdrawing the US from and defunding over 60 international organizations and treaties. And Germany reportedly plans to cut its funding by half for the World Health Organization’s Hub for Pandemic and Epidemic Intelligence.

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Global Health Watch: Health Policy Decisions Reversed, FY26 US Global Health Funding, America First MoUs Scrutinized & LEN for PrEP Advances

The US foreign assistance budget, if enacted, would restore some global health funds in a broader context of uncertainty, as US bilateral “America First” health MoUs advance without transparent plans for implementation or accountability. At the same time, abrupt reversals by the US Department of Health and Human Services of troubling health policy decisions underscore the Administration’s instability. Meanwhile, momentum around lenacapavir continues, recently approved by Brazil and with additional funding from Unitaid to reach more populations in South Africa and Zambia.

January 2026

The Future of HIV Prevention with Dr. Jeanne Marrazzo

On January 20, join us and Jeanne Marrazzo, IDSA CEO and AVAC board member, for The Future of HIV Prevention: A People’s Research Agenda for Speed, Scale and Equity, a webinar exploring the PRA’s people-centered framework, what the PRA tracks, why it matters and what’s at stake.

January 2026

Global Health Watch: Assault on US vaccine policy, contradictions in HPV and HIV vaccine science; 14 countries sign America First MOUs

The assault on vaccine policy and confidence intensified this week as the US overhauled its childhood immunization schedule. Beyond the US, 14 countries have now signed bilateral health agreements with the US under the America First Global Health Strategy. At the same time, the US President signed a new executive order withdrawing the US from and defunding over 60 international organizations and treaties. And Germany reportedly plans to cut its funding by half for the World Health Organization’s Hub for Pandemic and Epidemic Intelligence.

January 2026

Six Resolutions and Resources for Advocates in 2026 

As we look to the year ahead, we start by taking stock of the profound disruptions of 2025 and how the field responded. With immense challenges and historic opportunities ahead, we are making resolutions for the new year and sharing resources to advance our collective work in the months to come.

January 2026

Global Health Watch: A Year That Reshaped Global Health

The Lancet journal ended the year with a provocative editorial – 2025: an annus horribilis for health in the USA. But sadly, it was not just in the US; it has been a year of chaos and disruption globally. This 49th issue of Global Health Watch looks back—like many news stories this week—across 2025 to highlight the most consequential decisions, disruptions, and debates that defined the year and will continue to shape what comes next.

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January 2026

Global Health Watch: UNAIDS launches review, NIH GoF controversy, support for IDSA’s Jeanne Marrazzo, UK authorizes LEN for PrEP

This week the UNAIDS board approved a new Global AIDS Strategy and launched a formal review of the agency’s future; turmoil at the NIH continues over gain-of-function research; and the scientific community rallies around the Infectious Diseases Society of America’s (IDSA) appointment of Jeanne Marrazzo as its chief executive officer. Also, the UK regulatory agency approved lenacapavir for PrEP (LEN) marking its seventh regulatory approval in just six months.

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December 2025

30 Years of Standing for Science and Equity

This month, AVAC marked our 30th anniversary. Over three decades, the HIV field has evolved dramatically—but what we do, and why we do it, has remained constant: standing for science, equity, and community leadership, and ensuring evidence drives decisions that affect people’s lives. We’ve been able to do this work because of your partnership and support, and we are deeply grateful.

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December 2025

Global Health Watch: NIH turmoil + a high-profile lawsuit, future of UNAIDS, more Countries sign “America First” MoUs with US

This week covers the significant turmoil at the US National Institutes of Health (NIH), including a close look at the NIH deputy director’s role in disruptions in leadership and funding cuts, and a lawsuit filed by the former Director of the National Institute of Allergy and Infectious Diseases (NIAID). It also covers urgent civil society pushback against efforts to sunset UNAIDS, the rapid expansion of US “America First” bilateral health agreements across Africa, and what’s next for STI research, prevention and diagnostics.

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December 2025

AVAC Board Member Jeanne Marrazzo named CEO of IDSA 

AVAC enthusiastically applauds the selection of Jeanne Marrazzo, MD, to serve as the new chief executive officer of the Infectious Diseases Society of America (IDSA).

December 2025

The Future of HIV Prevention Depends on Speed, Scale and Equity 

We are in a golden moment, where innovation, evidence and opportunity align. But proposed funding cuts could undo everything. These aren’t abstract numbers on a page. These cuts would shutter clinics, slow prevention, restrict treatment, and roll back the very systems that allow new tools like LEN to reach people.

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December 2025

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P-Values Blog

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

Advocates Network

AVAC’s email list for organization and individuals interested in timely updates and critical perspectives on developments in biomedical HIV prevention.

Weekly News Digest

A comprehensive round-up of HIV prevention media coverage and scientific publications.

PxPulse

Each month this podcast uses interviews, discussion and first-person reflections to explore vital topics confronting the field of HIV prevention research.

PxWire

PxWire is AVAC’s quarterly update on biomedical HIV prevention. Each issue highlights key developments, challenges and opportunities, and features a centerspread infographic that provides a visual tool for framing these issues.

Pandemic Watch

Pandemic Watch is a curated news digest on the latest pandemic prevention, preparedness, and response (PPPR) news and resources.

Press Releases

A collection of official statements from AVAC.

AVAC in the News

Media clippings featuring AVAC, its staff and close partners in the news media.