Madalitso transformed HIV advocacy in Malawi by combining education, HIV prevention awareness and emphasizing sexual and reproductive health and rights. She conducted community sessions specifically designed to dispel myths about HIV/AIDS while partnering with local NGOs to increasing the distribution and uptake of PrEP in higher learning institutions, with a particular emphasis on reaching adolescent girls and young women.
Her approach included incorporating personal testimonies, making her advocacy efforts deeply personal and impactful. Beyond immediate community work, Madalitso built a lasting legacy by creating a mentorship network that pairs young advocates with experienced activists and documenting her work through media to influence broader policy discussions.