February 19, 2026
“In this moment of crisis and possibility, AVAC did what it has done for 30 years: We showed up, spoke out and worked with partners to push the field forward.” — Mitchell Warren, Executive Director
In a year marked by funding freezes, political disruption and historic scientific breakthroughs, we are proud to share our 2025 Year in Review — one defined by crisis and resilience.
The last year tested global health in unprecedented ways. AVAC showed up: helping protect hundreds of millions of dollars for global health; defending HIV programs and research; delivering trusted data, tools and analysis; and accelerating equitable access to innovations, like long-acting PrEP.
None of this would have been possible without you — our partners, our donors, and our community.
Inside the report, you’ll find:
- How AVAC equipped advocates, researchers, and partners with the context and tools needed to understand and act in a volatile environment.
- How our legal action and advocacy helped unlock global health funding – and hold the US Administration accountable.
- What it took to move lenacapavir for PrEP (LEN) faster into the market than any prevention product before it.
- Why defending global health requires sustained vigilance, strong leadership and robust partnerships.
AVAC — like the field at large — enters 2026 in transition. We stand ready for the future: supporting African leadership, strengthening bridges from R&D to delivery, and preparing for a new chapter as we move forward into our fourth decade as an organization.
As we look ahead, challenges remain. But the science is strong, new options are in the pipeline, and, with smart analysis, rigorous science, good policies and global partnerships, progress is possible — and essential. Thank you for standing with AVAC and helping to shape what’s next for HIV prevention, R&D and global health.