AIDS 2020 Virtual Begins Today!

In the time before COVID-19, many people would have been heading to the Bay Area in the US for AIDS2020 and to Mexico City for HIV2020. Now, both conferences are virtual. Read on for highlights and ways to navigate AIDS2020 Virtual, and stay tuned for other updates on HIV2020.

As in years past, AIDS2020 is offering the latest scientific breakthroughs on HIV, opportunities for advocates to come together to sharpen their agenda and new this year, a special day-long meeting devoted to COVID-19. The pre-conferences began today and there is a full agenda through July 10. Highlights Include:

  • The latest global HIV estimates from UNAIDS.
  • A survey of LGBTI+ people in 138 countries assessing the socioeconomic impact of COVID-19.
  • New evidence on what may be the first adult with HIV achieving long-term HIV remission without a bone marrow transplant.
  • Analysis of the safety and efficacy of the first long-acting injectable PrEP.

The satellites and regular conference sessions are only available to those who register for the conference. But, as in previous years, there will be a Global Village that’s free and open to the public, featuring networking zones, workshops and more.

Another complimentary offering is the final day of the conference—the July 10 special meeting on COVID-19, which will focus on developments in the research pipeline for SARS-CoV-2, policy analysis and lessons from the field. Click here for a free registration. And for more on the COVID-19 and intersections with HIV check out AVAC’s dedicated resources at www.avac.org/covid.

Navigating the Conference

Tracking the News

Program Highlights

Note: sessions may be streamed at multiple times, some are also streamed live, and many sessions are available to download on demand. Times reflect Pacific Daylight Time (PDT).

Every Day During AIDS 2020 Virtual

Networking Zones Channel
AVAC’s Research Literacy Zone (RLZN) will connect you to resources offering a foundation in biomedical interventions, the clinical trial process, advocacy for the integration of sexual reproductive health with HIV prevention and treatment, and the impact of HIV and COVID-19 on each other. The RLZN will also feature a series of virtual conversation and Q&As with leading researchers and advocates on topics such as: the status and implications of HVTN 083 & 084— two trials looking at the antiretroviral cabotegravir as a long-acting injectable PrEP; the AMP trial testing a broadly neutralizing antibody (bNAb) expected to announce results later this year; the larger bNAb research agenda; the basics of stakeholder engagement in research; an introduction to HIV cure research and more. Download the schedule here.

Wednesday, July 1

07:00–08:30, Pre-Conference Channel 4
Towards an HIV Cure: Opening session & Advancing the HIV cure field and debunking myths and misconceptions. At this pre-conference session, join a moderated discussion on cure strategies in resource-limited settings, myths and misconceptions, changing attitudes and advances in research.

Monday, July 6

06:00–07:00, Satellite Channel 3; 23:00–24:00, Satellite Channel 4
Bringing PrEP Closer to Home: Why is now the time for differentiated PrEP? A move toward more community-based and telehealth models have accelerated during COVID-19. Join this session Hear perspectives from providers, PrEP users, ministry of health, and global normative agencies and to discuss why differentiated service delivery DSD will be essential to significantly increase PrEPuptake by the end of 2020 and beyond!

05:00-06:00, Workshop Channel 2
The Power of Peers: Training HIV prevention ambassadors to support PrEP use in their communities. Priority populations such as adolescent girls and young women, men who have sex with men and other, must be offered meaningful ways to engage with peer support and effective advocacy in the context of rising community awareness to take PrEP and use it for as long as they need it. This workshop takes participants through the HIV Prevention Ambassador Training and learn how it boosts the impact of existing PrEP programs.

Tuesday, July 7

09:00-10:00, Satellite Channel 2; 12:00-13:00, Satellite Channel 3
HIV Vaccine: The search goes on! Despite life-saving advances in biomedical an HIV vaccine remains a necessity to finally end the epidemic. In this satellite, The Global HIV Vaccine Enterprise, NIH/HVTN/HPTN, with the participation of the South African Medical Research Council, IAVI, EU consortiums and AVAC are putting a spotlight on the breadth of ongoing research, and the role of funders, product developers, researchers and communities in sustaining HIV vaccine development.

Wednesday, July 8

06:00-07:00, Satellite Channel 2

One Year After ECHO: Integration in the Time of COVID. Results from the Evidence for Contraceptive Options and HIV Outcomes trial reflected the impact siloed services for family planning (FP), sexual and reproductive health, and HIV have on women’s health. The COVID-19 pandemic has only raised the urgency. This session looks at gains made in FP/HIV integration since the ECHO trial results; how COVID-19 is impacting the effort; and implications for the future. And check out our video series, One Expert, One Question, One Minute! Produced by AVAC and FP2020. Experts from all around the world share what we need to do for successful HIV/FP integration.

05:00–06:00, Workshop Channel 1
Data-Driven Advocacy in 2020 and Beyond: Tools and tactics for civil society to define and win high-impact change in the HIV response. Activists have marked recent wins using data strategically in campaigns. This session will explore case studies in East and Southern Africa and address the common barriers for civil society to deploy data effectively, such as missing or poor-quality data and lack of access.

Thursday July 9

08:00, IAS Networking Booth
Join a conversation with cure advocates on “what do you want to know about cure?” IAS/AVAC Advocacy-for-Cure Fellows Philister Adhiambo from Kenya Medical Research Institute (KMRI) , Owen Mulenga from (MUHJU), Josephine Nabukenya from the Treatment Advocacy and Literacy Campaign will answer your questions.

On Demand-Only Sessions

Symposia and Bridging Session, On-Demand Channel
Ending the HIV Epidemic: Optimism, realism and disparities. Join to hear four perspectives on where we are and where we should go as we aim to end the HIV epidemic around the world. Speakers will take four distinct perspectives, each speaking across geographies and populations.

Symposia and Bridging Session, On-Demand Channel
How did they do it? What successful communities can teach all of us about making dramatic progress against HIV epidemics and what this means in the age of COVID. Cities, regions and countries around the world have brought down HIV incidence and mortality. How did they do it? Last year, amfAR, AVAC and Friends of the Global Fight, in partnership with Kaiser Family Foundation, released a report, Translating Progress Into Success to End the AIDS Epidemic, looking at success stories. In this session, advocates and researchers from these case studies discuss how to apply the lessons they learned to advocacy and policy.

Symposia and Bridging Session, On-Demand Channel
Bound But Not Gagged: Resilience in the era of the global gag rule. Join top learn about the impact of the global gag rule and the domestic (US) gag rule on women and girls around the world, including key populations and how they have responded.

It’s an exciting and important time in HIV prevention research and advocacy. At AIDS 2020 Virtual, we can come together—COVID-19 be damned. As intrepid, committed advocates, we can push an HIV agenda forward to a future we clearly see—with many options for evidence-based prevention, well-funded research, and an integrated and equitable global response to the public health threats of today and tomorrow.

We Need DSD Now More Than Ever: The frontier of human rights-centered services for HIV treatment & prevention

The stories are coming from Malawi, South Africa, Uganda, Zambia, Zimbabwe and elsewhere—people struggling to get treatment for chronic illness, failed attempts to refill ARVs and key prevention commodities, high numbers reporting they can’t get to the clinic, informal groups coming together to find and deliver medication. These are pictures of communities in lockdown from COVID-19, facing the consequences to public health.

This troubling news from advocates in sub-Saharan Africa has grave implications. According to a May 2020 analysis of multiple mathematic models by the HIV Modelling Consortium, COVID-related barriers to HIV treatment, care and prevention could result in 500,000 additional deaths from AIDS-related illnesses. The world has made tremendous progress against HIV. If we allow COVID-19 to set us back, we could lose more than a decade of these gains. As AVAC’s Mitchell Warren said, “We cannot play global health whack-a-mole and ignore other devastating diseases while we turn attention to COVID-19. HIV treatment and prevention interruption cannot be an acceptable result of COVID-19: in that model, even if we succeed against COVID-19, we fail against everything else.”

The good news is we know how to preserve the progress made: we have to urgently expand models for differentiated service delivery (DSD), and we have to do it right now. DSD puts clients at the center and adapts—tailoring HIV programs and services to reflect the preferences and expectations of various groups who need HIV prevention or treatment.

In Zimbabwe, a DSD program of the Batanai HIV & AIDS Service Organisation (BHASO) has succeeded with allowing health care workers to bring needed care and medicine to clients, instead of requiring clinic visits. The program is expanding and is exactly the kind of initiative that others should model.

DSD can mean people get their medications, learn about prevention options, find the counseling they need, and stay connected to care. DSD can mean individuals at risk of diseases such HIV or TB are engaging with healthcare that works for them.

AVAC has been expanding its advocacy for DSD, even before COVID-19 gripped the world. Why? Because tenaciously high incidence rates, a heartbreaking number of people lost to follow-up, and the millions of people who don’t know their status or are not virally suppressed can all be addressed with DSD. This means developing programs and services that clients and communities have helped to design, programs that offer a range of approaches, programs that support diverse needs.

Now we need DSD more than ever, so people can access the care, treatment and prevention they need in the midst of COVID-19 lockdowns and disruptions to the healthcare systems in their communities. The results of this new modeling escalate the urgency for widespread adoption of DSD approaches.

The modeling is detailed and the findings are drastic: five teams contributed to models looking at disruptions of three and six months and their impact on AIDS mortality and incidence. According to the findings, if services are disrupted for six months then additional deaths will range from 471,000-673,000 in the following year, which could bring the death toll from AIDS in 2021 to more than 900,000. Those figures “set back the clock” on the HIV epidemic to 2008, a year when the WHO reports 950,000 people died from AIDS in the region. And the heightened rates of loss of life are expected to last for years. Other predictions include reversed gains in mother-to-child transmission with a “drastic” rise of infections among children, up by 37 percent in Mozambique, 78 percent in Zimbabwe and 104 percent in Uganda, and adverse impacts on prevention efforts as well.

As advocates, we cannot allow these scenarios to come true. As UNAIDS executive director Winnie Byanyima says, “The COVID-19 pandemic must not be an excuse to divert investment from HIV. There is a risk that the hard-earned gains of the AIDS response will be sacrificed to the fight against COVID-19, but the right to health means that no one disease should be fought at the expense of the other.”

WHO leader, Dr. Tedros Adhanom Ghebreyesus, is also raising the alarm, “We must read this as a wake-up call to countries to identify ways to sustain all vital health services.”

Watch-dogging country governments to adapt HIV service delivery is vital to sustain and advance three decades of progress in HIV prevention and treatment. Countries must develop the capacity to deliver DSD rapidly and safely, while also pursuing the strongest and wisest course of action against COVID-19.

To get the job done:

  • Give people options to choose where and when to access their ART and prevention, and make it easy for them to do so. No one size fits all.
  • Governments and donors must establish models that revolve around the clients, not the health system.
  • Governments, donors and implementers must anticipate factors such as geography, HIV prevalence or individual barriers to care and address those factors in programs that are codesigned with clients and community. This creates models for service delivery that serve diverse populations. All this necessarily involves investment in both lay and professional health workers for quality clinical care that includes psychosocial support.
  • Governments and donors should expand and invest in DSD models for treatment, which include: six monthly refills, community ART groups, nurse-led community ART distribution points, door-to-door ART delivery and there are many more!
  • The field must also use these models to guide efforts to develop DSD for PrEP and HIV prevention. These include conducting online risk assessments and follow-up consultations, providing multi-month refills for continuing clients, peer drop-offs and courier delivery of PrEP refills, to name a few.
  • It’s time to seize opportunities for integration with other essential services such as: sexual reproductive health and rights (as recently highlighted in a new report from UNAIDS and WHO), interventions for gender-based violence (GBV), and the response to COVID-19. This requires an enabling policy environment and robust program monitoring and evaluation.
  • Human rights should never be compromised during the COVID-19 pandemic. Governments must find ways to deliver both COVID-19 and HIV programs within a human rights framework.

AVAC and our partners are leading the charge on DSD advocacy and on identifying where COVID-19 is impacting HIV service delivery. Along with other HIV advocates, we have recommended people living with HIV (PLHIV) receive three to six month refills of ARVs during lockdown. Georgetown University’s HIV Policy Lab has been writing about the need for these multi-month dispensing strategies and policies that support them. COMPASS advocacy partners in Malawi, Tanzania and Zimbabwe have engaged with their respective ministries of health and identified that staffing and supply shortages in ministries and among implementers are making it difficult or impossible to meet the recommendation. Advocates are continuing to follow up with ministries, implementers and funders to find ways to make DSD work during this time.

We are urgently working with TB, SRHR and other health advocates locally and globally to ensure that people receive the care, treatment and prevention they need for all aspects of their health. It isn’t an easy task. The effort requires collaborations and investment at a scale never before seen in global health. But there is no other choice. This is the only way.

Good Participatory Practice (GPP) Online Training

This 10-week interactive and online course will help researchers and clinical trial stakeholder to apply the Good Participatory Practice (GPP) Guidelines in their unique settings. In this unprecedented time, sustaining effective partnerships is more crucial than ever before. This course provides a personalized learning experience, global knowledge, tools to advance GPP implementation in diverse contexts and access to GPP experts and professional networks. For more information, send an email to gpponlinecourse@avac.org.

The course starts runs from June 22 to August 28, 2020. Enroll now at engage.avac.org.

Black Lives Matter: A Call for Justice and Equity

Black Lives Matter.

The Black lives of AVAC’s staff, partners and friends matter. The Black lives of those who live near our office in Harlem matter. The Black lives of those on the streets across the United States and around the world calling for justice and equity matter. It’s more important than ever to say these fundamental truths.

Since AVAC’s founding 25 years ago, our focus has been advocating for solutions to HIV, a virus that disproportionately affects Black and Brown people around the world. In 2020, we have widened our focus to advocate for an equitable response to COVID-19, another virus that is disproportionately devastating Black and Brown communities in the US and – increasingly – around the world.

We are HIV and global health advocates and activists, and our work is fundamentally about social justice and human rights. In the United States, police brutality is a moral, ethical and public health crisis that must be addressed by every one of us.

We can’t be silent. We won’t be silent. We join the call for true leadership from our government, for an end to police brutality and for justice and equity that addresses the systemic racism in the United States. We know we can’t address HIV or COVID-19 without addressing this insidious epidemic that also attacks communities of color, and we are committed to working with partners and allies to address it.

The AVAC team stands in solidarity with the families of Ahmaud Arbery, George Floyd, Tony McDade, Breonna Taylor, and the thousands of others whose names we know and those whose names we don’t know, who have lost their lives and opportunities to the epidemic of racism. We stand in solidarity with those on the streets every day calling for justice.

As an organization, AVAC is committed to coming together to interrogate our own privilege and power and ensure we do better as allies and partners. We know it won’t be easy and we know we won’t always get it right, but we are committed to listening, responding and learning. And we commit to redoubling our work of advocating for equity, diversity and social justice as we continue to seek solutions to HIV and other public health crises.

A Call for Justice and Equity

The AVAC team is united in sorrow and anger at the inequities that are being laid bare in America today. We advocate every day for an equitable HIV response, but we know that we can’t stop there. We stand with those who are calling for a more just and equitable world.

Advocates Take the Bullhorn: New resources on AVAC.org

In case you missed it, AVAC has a number of new resources to support our collective advocacy for HIV prevention research and an equitable, evidence-based response to COVID-19.

HIV Advocates Demand an Ethical Response to COVID-19

Unprecedented focus on vaccine development for COVID-19 put a new perspective on HIV Vaccine Awareness Day (HVAD) on May 18.

There’s never been more at stake or more opportunity to build global capacity to ethically develop and deliver vaccines, which are essential to eventually end HIV and face future epidemics.

To Accelerate Search for COVID-19 Vaccine, Look to HIV and Act Globally

This post first appeared on Devex.

In just six months, the virus that causes COVID-19 has spread around the world, infected over 5 million people, and exacted devastating public health and economic tolls that are only just beginning. Unprecedented efforts to accelerate the development of a vaccine for the virus underscore the urgency of this public health crisis.

We have the benefit of history to provide a clear vision of what must happen with COVID-19. We stand on the shoulders of giants in the fight against HIV who never took “no” for an answer: advocates who demanded a vaccine because they knew their lives depended on it. At the same time, they acted as if a vaccine would never arrive, thereby accelerating the development and delivery of safe and effective treatment and prevention options that have had a dramatic impact on the HIV epidemic.

Since the coronavirus crisis began, we’ve seen Gregg Gonsalves and other advocates who honed their craft advocating for HIV solutions reemerge and lead the charge. And earlier this month, the New York-based organization PrEP4All, which was founded to increase access to HIV medication, issued a report calling for research and development for coronavirus prevention options.

As we know so well from over 40 years of experience in the HIV response, developing and delivering prevention and treatment options at scale is essential to containing an epidemic. But no durable and sustainable end to any epidemic is possible without a vaccine.

Today — just months into this pandemic — there are already over 100 COVID-19 vaccine candidates in the product development pipeline. While the scientific reality is that the majority of these candidates will fail in the early stages, the sheer volume of products is evidence of the global commitment to combating this virus.

This is also another example of where we are drawing on the decades of research and hard-won progress in the field of HIV/AIDS. A recently launched report explored HIV vaccine platforms that are helping accelerate the drive for coronavirus vaccine development and are key priorities for an effective response to this pandemic. Many of the platforms, research partnerships and clinical trial capacities used in COVID-19 vaccine research were developed as part of the effort to find a preventive HIV vaccine.

To winnow down the coronavirus vaccine pipeline to probable winners, global collaboration, harmonized efficacy trials and data-sharing are key. We are already seeing tremendous political leadership, such as the Coronavirus Global Response, the recent European fundraising effort that received more than $8 billion in pledges. This also includes the Joint United Nations Programme on HIV/AIDS’ call for a “people’s vaccine,” with more than 140 world leaders and experts demanding that vaccines, treatments and tests be “patent-free, mass produced, distributed fairly and made available to all people, in all countries, free of charge.”

The US has a history of leadership in vaccine development and a particularly important role to play in the global response. The Dale and Betty Bumpers Vaccine Research Center, or VRC — originally established at the National Institutes of Health in 1997 by then-President Bill Clinton to accelerate the development of an HIV vaccine — is taking a leading role in developing promising COVID-19 vaccine candidates and getting them into clinical trials. In May, NIH leaders, including VRC and the HIV Vaccine Trials Network, published a strategic approach to coronavirus vaccine R&D.

Then came the announcement of Operation Warp Speed by the administration of President Donald Trump, with the wildly ambitious goal to deliver the 300 million doses of a vaccine by January 2021. While the specific details for the plan have yet to be released, it is being positioned as a unilateral effort, ignoring possible vaccine candidates from China and reserving the end product for Americans. This is a mistake; global health, not nationalism, must drive vaccine development and the overall COVID-19 response.

Whether there is a vaccine in time for the new year, or in 18 months, or ever, collaboration across countries, disciplines and disease areas will be crucial to the success of this effort. It is also critical that coronavirus R&D reflects the realities of people’s lives and that products and strategies developed to combat COVID-19 are informed by and will be accepted and used by the communities at greatest risk — the elderly, health care workers and those with underlying conditions.

To ensure that product development success becomes public health victory, massive public, private and philanthropic investment globally is needed to accelerate the science; communities must be engaged to both accelerate research and ensure eventual uptake; and equitable access must be the highest priority.

While some groups appear harder-hit by COVID-19, everyone on the planet will potentially need this vaccine. Policymakers, private industry, donors, regulators, the World Health Organization, Gavi and others must work to ensure rapid access to all who need new interventions. In April 1955, when journalist Edward R. Murrow asked researcher Jonas Salk who owned the patent for the polio vaccine, Salk said: “Well, the people, I would say. There is no patent. Could you patent the sun?”

HIV Advocates Respond to the COVID-19 Crisis

This post first appeared on USAID.gov. For more information on COVID-19, please consult our COVID-19 and HIV Resources page, which includes a comprehensive set of information and advocacy Resources for Advocates. Daisy Ouya is AVAC’s Communications Advisor.

The COVID-19 pandemic demands that everyone apply their skills, resources and networks to empower communities and ease collective suffering.

The USAID-supported Coalition to Accelerate and Support Prevention Research (CASPR) was created in 2016 to expand robust advocacy efforts around HIV prevention research. We are a network of research-literate HIV prevention advocates working globally with an emphasis on sub-Saharan Africa. The Coalition places a special focus on literacy in infectious diseases, clinical research and trial design, through its long-standing partnerships with local and regional civil society, researchers, national governments, normative agencies and the media.

Although HIV and SARS-CoV-2 (the virus that causes COVID-19) have many important differences, such as mode of transmission, infectivity, case-fatality and global distribution, this emerging pandemic emergency has given rise to many déjà vu moments where the well-honed HIV advocacy skills of CASPR members can be applied. And we are rising to the challenge.

Using virtual gatherings, public statements, media trainings, blogs, podcasts and social media, the Coalition is actively debunking misconceptions, conspiracy theories, anti-vaccine and anti-research narratives. We are empowering our communities to recognize the myths and outright disinformation about COVID-19 and about research, and actively promoting the only evidence-based prevention options currently known: physical distancing, handwashing, and the proper use of face masks.

We are educating communities on efforts toward vaccines and therapeutics, the research and development process, the ethical principles that govern clinical research globally, and the strengths and limitations of mathematical modelling as it applies to the COVID-19 and HIV epidemiology. In parallel, we are highlighting the importance of global cooperation in COVID-19 research through initiatives such as the COVID-19 Clinical Research Coalition. A recent global webinar and new podcast examine the huge contributions of HIV vaccine research and partnerships to the current search for COVID-19 vaccines and therapies, but also how current COVID-19 research is likely to contribute to HIV vaccine research.

Ethical research for solutions to COVID-19 requires that communities be fully engaged. The UNAIDS/AVAC Good Participatory Practice Guidelines for biomedical HIV prevention trials, the World Health Organization’s Good Participatory Practice for Trials of Emerging Pathogens (GPP-EP), and the UNAIDS/WHO Ethical Guidelines for Biomedical Research Involving Human Subjects are key references in human rights-based research conduct. Ethical considerations also demand a swift and equitable delivery of testing, treatment and prevention options, prioritizing those most at risk.

While recognizing the global havoc wreaked by the novel coronavirus pandemic, we are tracking and condemning the proliferation of dehumanizing and stigmatizing language. We are advocating strongly against branding people ‘COVID suspects’, ‘super-spreaders’ or worse. Our recent webinars with journalists in Africa and India discussed journalists’ safety in COVID-19 reporting, as well as the role and power of language in the response.

Renowned African researchers and advocates have featured on webinars we have hosted to unpack the effect of COVID-19 on HIV prevention clinical trials and health services in Africa. Several CASPR members have been asked to contribute to radio and television panels in our respective countries to discuss the pandemic and its intersection with HIV.

We are pushing for an age- and gender-responsive, human rights-based approach to COVID-19—like the decades of HIV activism that has shaped the response to HIV & AIDS. Our goal is to ensure that equity and our shared humanity is at the center of the response at all levels and confers special protection for those likely to suffer the greatest socio-economic shocks and deleterious health impacts from the COVID-19 pandemic.

It is crucial that we renew our advocacy to strengthen health systems and to expand African domestic funding for health, as countries urgently mobilize their healthcare resources to deal with the COVID-19 crisis.

As for HIV, we are tracking COVID-19 research and pipeline of products and documenting the profound effects the COVID-19 crisis is having on promising HIV efficacy trials in communities. We stand with fellow advocates and researchers who have identified the need for an efficient resumption of HIV prevention research as soon as it is safe to do so.

This HIV Vaccine Awareness Day, we celebrate and thank the clinical trial participants, health workers, researchers and funders coming together to develop durable public health solutions for humanity.

New Resources on AVAC.org

In this time of COVID-19, new information and new questions arise daily with implications for global health advocacy and for the HIV response at large. In the midst of this, HIV research has taken some major steps forward as well. AVAC has produced a number resources to keep you informed and guide your advocacy on all these issues.

In the Headlines: Research on long-acting PrEP for HIV prevention

AVAC’s Statement on HPTN 083—HPTN 083 stopped the placebo arm of this trial two years early, after a rescheduled review of the data showed the product was at least as good as oral PrEP. AVAC’s statement explains the trial, the findings and talks about what’s next. For a deeper dive into the trial design check out our infographic or the Px Pulse episode on the issue. You can also join an HPTN webinar on the results tomorrow, May 22nd, at 10:30 ET.

COVID-19: Research standing on the shoulders of HIV

Expanding Our Work: Integrating HIV prevention with sexual and reproductive health

AVAC has long promoted a research agenda centered on women, but both the ECHO trial results and the rollout of PrEP have highlighted the urgent need to bring proven interventions for both HIV and sexual and reproductive health to the women who need them. In our blog Programs, Products, Services and Users: HIV & SRH integration is the future of prevention we outline our expanding advocacy to advance HIV/SRH integration, introduce a suite of new resources and our new page on avac.org devoted to HIV/SRH integration.

Injectable PrEP Effective in MSM and Transgender Women

We are writing with breaking PrEP news—data now show that bi-monthly injections of long-acting cabotegravir (CAB-LA) appears to be safe and effective in preventing HIV in cisgender men and transgender women who have sex with men.

The data come from a large-scale efficacy trial, HPTN 083, which is ongoing in 4,500 participants at sites in the Americas, Asia and South Africa. These data were announced after a regularly scheduled review by its data and safety monitoring board (DSMB) found that CAB-LA provided significant protection against HIV. As reported, the DSMB recommended that all HPTN 083 trial participants be told which active drug (CAB-LA or oral TDF/FTC) they were receiving and that placebos be dropped from the study. The study will continue to completion with all participants receiving one of the two active products.

Importantly, these data only apply to the population in HPTN 083—and there is an ongoing “sister” study, HPTN 084, which is evaluating CAB-LA for prevention in cisgender women. This trial began after HPTN 083 and is still enrolling participants. The DSMB recommended that HPTN 084 continue per protocol with both the active and placebo products.

The data announced today by the HPTN and partners show the promise of CAB-LA as a prevention option for some people. This is an exciting development and welcome news for HIV prevention but questions remain, including whether it’s safe and effective in cisgender women, how a bi-monthly injection might be delivered if licensed, how these findings will affect ongoing HIV prevention trials and more.

The HIV Prevention Trials Network (HPTN) held a community webinar on May 22 to discuss the preliminary results of HPTN 083 and the importance of its sister study, HPTN 084, as HIV prevention for cisgender women. Click here to watch the recording.