Undetectable: New resources from Doctors Without Borders on viral load testing

Viral load testing is commonly used in high-income countries but remains a relative rarity in many low and middle income settings. This test, which measures the amount of HIV in the blood, has historically been viewed as too costly for widespread use and as unnecessary for good clinical care of HIV. The past few years have seen momentum building towards adding viral load to HIV care in all settings, including resource-poor environments.

Doctors Without Borders, usually known by its French name, Médecins Sans Frontières, continues to produce invaluable resources for advocates seeking to understand why viral load is useful, feasible and worth demanding as part of a comprehensive HIV response. Their new report, Achieving Undetectable: What questions remain in scaling up HIV virologic treatment monitoring?, includes additional evidence from a five-country study of viral load implementation and MSF’s own operational experience in viral load scale-up. And in our database you can also find other, related MSF documents released over the past year.

Prepping Gay Men for PrEP

Adebisi Alimi is an LGBT advocate, former AVAC PxROAR Europe member and a 2014 Aspen New Voices Fellow. This article first appeared in Project Syndicate.

In October, two groups researching the effectiveness of a potential breakthrough drug in the fight against HIV did something unusual. They announced that the therapy they were testing, an antiretroviral drug called Truvada, had proved effective enough to end the randomized phases of the trials, and that they were offering the pill to all of the studies’ participants.

The researchers found that gay men who take Truvada, in addition to using condoms when they have sex, were significantly less likely to contract HIV. This is further evidence of the effectiveness of pre-exposure prophylaxis (PrEP), a technique by which people who are HIV-negative use antiretroviral drugs to protect themselves from infection. In 2011, a trial funded by the Gates Foundation found that straight couples using Truvada reduced the risk of transmitting HIV by 73 percent.

Those fighting to prevent the spread of HIV/AIDS thus have a new tool in their arsenal. The question now is how best to deliver it to those who need it most: gay men in developing countries.

This summer, the World Health Organization took an important step to that end, recommending PrEP for all gay men and men who have sex with men, making it the first major international health organization to do so. The WHO estimates that increased use of PrEP could reduce HIV infections by up to 25 percent over the next decade among men who have sex with men (this category includes anyone with elevated risk, not just those who identify as gay).

But an important obstacle remains: the legal predicament of gay men in much of the developing world. In countries like Nigeria, where anti-homosexuality legislation has recently been approved, those following the WHO’s new PrEP guidelines could find themselves subject to imprisonment.

The climate of officially sanctioned homophobia in Nigeria has already set back the fight against AIDS. In 2006, a study found that 13 percent of men who have sex with men in Nigeria were HIV-positive, compared to 4.5 percent of all Nigerians. By 2012, the HIV rate among men who have sex with men had jumped to 17 percent. Meanwhile, an increasing number of men reported encountering homophobia at healthcare centers, making them less likely to seek help.

The consequences could not be more serious. Two years ago, a young HIV-positive Nigerian man contacted me on Facebook to tell me about his monthly ordeal at the clinic. The nurse at the hospital spent more time lecturing him on the evils of homosexuality than telling him about the drugs he was taking and their possible side effects. The man, a third-year medical student, told me that he had decided to stop going to the clinic. When I asked how he would continue treatment, he said that he had a friend abroad who could get him the drugs. Less than two years later, I saw a Facebook update announcing his death.

My Facebook friend is not the only one who has paid the price for Nigeria’s homophobia. A preliminary report from the Solidarity Alliance Nigeria, a coalition of gay, lesbian, bisexual, and transgender (LGBT) organizations, details a huge decrease in the use of HIV services by men who have sex with men in the six months following the enactment of the anti-gay legislation. The decrease ranges from 40 percent in Lagos – Nigeria’s most cosmopolitan city – to 70 percent in Kano, a predominantly Muslim state.

Nigerians living with HIV must do more than just fight the infection; they also must brave social stigma, weather discrimination by secular and religious institutions, and now, potentially, face threats from the legal system. In this environment, the promise of PrEP begins to dim, as the risks of seeking treatment outweigh the potentially life-saving benefits.

The story is similar in Uganda. Last spring, as legal persecution of gays there mounted, the government raided an HIV clinic and withheld its operating license for providing care and support to HIV-positive men who have sex with men.

As an African activist with more than ten years of experience in the fight against HIV, I hope that the WHO will build on its important first step of advising the use of PrEP. That means initiating a public conversation with countries like Nigeria, Uganda, Gambia, and Russia on the importance of inclusion in the battle against HIV.

The WHO should make it clear that while it may not be advocating for LGBT political rights, it is determined to ensure that all those who can benefit from PrEP are able to access the necessary drugs, without fear of legal consequences. Researchers, drug companies, and human-rights campaigners must take up the fight to ensure that PrEP is made available – without risk – to those who need it most.

Ugandan Advocates Emphasize Prevention Based in Evidence, Not Opinion

At this year’s World AIDS Day commemoration in Uganda, President Yoweri Museveni’s remarks were reported to question some of the scientifically proven HIV prevention interventions including voluntary medical male circumcision and condoms.

Political leadership is critical for an effective HIV/AIDS response. Over the past twelve months, Ugandan civil society has worked tirelessly to address national challenges including the anti-homosexuality law and enforcement of a law criminalizing HIV transmission. They have also responded to these recent developments.

Here is an op-ed written by Regional Policy and Advocacy Manager at the East/West Africa Bureau of the AIDS Healthcare Foundation and former AVAC Fellow Alice Kayongo-Mutebi.

Nigerians Call for Protection of the Rights of All Nigerians Including LGBT Persons

As the world marks this year’s International Human Rights Day on December 10th, a coalition of Nigerian human rights defenders have launched a campaign calling on the international community to raise awareness about the ongoing violations against LGBTI individuals across the country. 

According to UNAIDS Nigeria has the second largest HIV epidemic globally—in 2012, there were an estimated 3.4 million people living with HIV in Nigeria. In 2010, national HIV prevalence in Nigeria was estimated at 4% among the general population and 17% among men who have sex with men.  

AVAC will continue to work with civil society organizations and activists in Nigeria and all countries where criminalization of HIV status, homosexuality and other practices or identities undermines the right to health and life. To learn more about what we are doing, visit our “Strategic Initiatives” page and to receive updates in your inbox, please join our Advocates’ Network. Stay tuned—and stay in touch.

The press release for this effort is below. 

 #FREEANDEQUALNAIJA CAMPAIGN 

LAUNCHED TO PROTECT THE RIGHTS OF ALL NIGERIANS, INCLUDING LGBTI INDIVIDUALS.

A group of Nigerian human rights defenders have united in the #FreeAndEqualNaija media drive aimed at giving prominence to the protection of the rights of all Nigerians including lesbian, gay, bisexual, transgender and intersex (LGBTI) individuals. 

Across the country this year, thousands of Nigerians have been victims of a wide range of human rights violations. Among them many have experienced violence, due to perceived or real difference in their sexual orientation or gender identity. Recorded violations included mob justice, arrests, sexual assaults, unlawful detention, eviction from homes, discrimination in health care and education settings, blackmail, extortion, public humiliation and even killings. In most cases, access to justice for victims was often impossible, and compounded by negative media reporting and lack of assistance from public authorities. Through the 

#FreeAndEqualNaija campaign, human rights defenders aim to create more awareness of the need to include sexual orientation and gender identity in the broader spectrum of human rights advocacy in Nigeria. 

The harm caused by gender-based violence (as highlighted in Nigeria last month) and barriers in accessing justice for victims of sexual assault is particularly crucial for sexual minorities. And like millions of their Nigerian counterparts, poverty, youth unemployment, HIV/AIDS and exclusion from public education further compound the plight of sexual minorities. Campaigners therefore wish to forge more partnerships with the mainstream human rights movement, as well as religious and opinion leaders. 

This year, two new resolutions of the African Commission on Human and People’s Rights (ACHPR) have called on member states to combat violence and discrimination related to sexual orientation and gender identity. The ACPHR has also expressed concern for the welfare of Nigerian human rights defenders following the passing of the Same Sex Marriage Prohibition Act 2013. #FreeandEqualNaija campaigners appeal Nigerian authorities to update its legal and policy apparatus regarding LGBTI individuals to be in line with standards recommended by the ACPHR and the United Nations Human Rights Council. 

According to Jake Okechukwu Effoduh (campaign member), “Much work is needed to highlight the negative impact of deeply held prejudices towards minorities, who are victimized simply because of who they are or who they love. This sad situation should concern all of us”. 

#FreeandEqualNaija campaigners are inviting members of the public to join the human rights movement on December 10, and show their support for a more tolerant Nigeria. According to Cheikh Traore (campaign member); “The public can help raise awareness through social media and conventional media with stories which reflect the harmful impact of prejudice on families and ordinary people’s lives”. 

The public is invited to share their experience relating to the harmful impact of prejudice towards sexual minorities. The public is also encouraged to use Facebook, Instagram and other social media platforms to promote the freedom and equality of all Nigerians. Tweet with the hashtag #FreeAndEqualNaija as well as follow @FreeEqualNaija on twitter to share stories relating to the hurtful impact of discrimination towards sexual minorities.

According to Dorothy Aken’Ova (campaign member) “All forms of violence experienced in Nigeria are interlinked. We will eliminate all forms of violence when we have the political commitment to protect the human rights of ALL”.

Children are Not Tiny Adults – The Science of Finding a Pediatric “Cure” for HIV

The case of the “Mississippi child” has intrigued scientists since Deborah Persaud first announced the child’s lack of detectable virus at the Conference on Retroviruses and Opportunistic Infections in March 2013. The folks behind the CUREriculum, a group of advocacy organizations and the Martin Delany collaboratories, partnering with leading researchers, hosted a pilot webinar on December 3rd to an audience comprised of US based researchers and community members. Kaitlin Rainwater-Lovett, PhD, a translational immunovirologist (she knows how to use basic science to create practical solutions) research fellow in Deborah Persaud’s lab, led an interactive conversation that highlighted the struggles of finding a pediatric “cure” and the strategies the field is pursuing to tackle them. The CUREriculum is scheduled to launch in early 2015.

You can download a copy of the pilot webinar slides here

To find out more, contact Jessica Handibode at [email protected] or Karine Dube at [email protected].

New publication: Journal of Virus Eradication

SOURCE: US Military HIV Research Program (MHRP)

US CDC Says to Counsel Men About the Cut

Earlier this week, the US Centers for Disease Control and Prevention (CDC) released draft recommendations on male circumcision, stating that men of all ages (and parents of male minors) should be counseled on the health benefits of voluntary medical male circumcision. The recommendations do not call for universal male circumcision but recognize its power to prevent sexually transmitted infections and suggest a discussion about male circumcision with providers:

These recommendations are intended to assist health care providers in the United States who are counseling men and parents of male infants in decision making about male circumcision conducted by health care providers (i.e. medically performed) as it relates to the prevention of human immunodeficiency virus (HIV) infection, sexually transmitted infections (STIs), and other health outcomes. Such decision making is made in the context of not only health considerations, but also other social, cultural, ethical, and religious factors.  

The document—Recommendations for Providers Counseling Male Patients and Parents Regarding Male Circumcision and the Prevention of HIV Infection, STIs, and other Health Outcomes—reflects the data that show in heterosexual men that medical male circumcision can reduce risk of HIV infection by around 60 percent and reduce risk of other sexually transmitted infections such as HPV and herpes.  These data are the basis for voluntary adult male circumcision programs implemented as a primary strategy to prevent HIV in 14 priority countries in East and Southern Africa, where HIV rates are high and circumcision rates are low. 

Acknowledging the different epidemics between the US and countries in Africa, the CDC notes that some subpopulations in the US where HIV continues to rage could benefit from male circumcision—in particular heterosexual men at higher risk including African-American and Hispanic men, traditionally living in communities with higher rates of HIV and lower rates of male circumcision. 

There are little data on male circumcision’s effect on risk reduction in gay men and other men who have sex with men whose risk for HIV exposure is primarily via anal sex, although there is a biological rationale for a potential protective effect for the insertive partner (or “top”) in anal sex. But data on effect are not available. 

The draft recommendations are open for public comment for 45 days, closing on January 16, 2015. Visit the online comment portal here.

In 2012, the American Academy of Pediatrics updated its position on male circumcision noting that the benefits of newborn male circumcision outweigh the risks and that those families interested should have access to it. 

For more on medical male circumcision, visit AVAC’s webpage on the topic

People Must Take Their ARVs So They Never Get to ‘Bulawayo’

On December 3, women’s rights and HIV prevention advocate Yvette Raphael talked on South African radio about her experience as an HIV-positive woman and discussed how treatment can protect HIV-negative people in serodiscordant relationships. Raphael, who is also a 2014 AVAC Advocacy Fellow, used creative metaphors to help explain the difference between viral load and CD4 testing. Want to know what these diagnostic tests have to do with driving to Bulawayo? Have a listen!

AIDS, Intersectionality and the View from Harlem

The AVAC staff works with partners around the world. But we come to work every day in New York City. We live in many boroughs, we hail from different countries and we offer up our prayers and hopes in different ways.

Today we are united in our sorrow and anger at the reality of a world, a country and our home city that has failed to deliver justice equally to all men and all women, regardless of the color of their skin, who they love or how much money they have.

We are united, too, in our to-the-core belief that black lives matter. Black men’s lives matter. Black women’s lives matter. The lives of black children matter.

Such a simple statement ought not to be the stuff of placards. But right now it is. And this reality has a profound effect on every aspect of the world—including work on HIV and AIDS. There is no health, for individuals or communities, without justice. This means equity in access to high-quality, non-discriminatory information and services. But it extends beyond the clinic—to the streets, bars, churches and courtrooms. Where states discriminate or persecute, whether by statutes that criminalize behavior of HIV status, or by selectively enforcing laws in a way that leaves segments of the population more frequently imprisoned or in handcuffs, that harms everyone. Trust in hospitals, clinics and health services falter. Fear—often justified—prevails.

On World AIDS Day, at the Apollo Theater, just five minutes from AVAC’s office—a vibrant coalition of activist groups, service providers and politicians launched a plan to end AIDS in New York State by 2020. Without justice in the execution of laws and the practice of policing, this plan cannot succeed. We look to the local politicians who launched this plan to systematically address the intersectionality between race, poverty, criminalization and policing that drives the epidemic in so many communities in the city and state we love. We support and draw strength from individuals and coalitions working on these very same issues in cities and communities throughout the United States and around the world.

In global health the word “we” gets used—often with good intentions—to signal a broad solidarity, a shared identity. And there is a lot of solidarity and sharing in the fight against AIDS. But many times, even with the best intentions “we” conceals a presumption of identity: the color of your skin, the level of your education, the location of your birth, the leanings of your politics.

Strong movements celebrate diversity and acknowledge what is difficult and beautiful: We are not all the same. This is why AVAC uses “we” with care, and largely about the team that works and plays and grows together here in New York every day.

Which is how we’re using it today.

We are in solidarity with the families of Eric Garner, Michael Brown and Tamir Rice, and with the families of many other men and women whose names we do not know. We are marching, praying, singing and putting our children to bed with an extra squeeze at bedtime during these difficult days. And we stand with all of our partners who do this work in so many countries and communities around the globe. Together, we will continue linking health, HIV, racial justice, poverty alleviation and criminal justice reform. Together, we will continue doing the work that needs to be done.

Support AVAC on #GivingTuesday

As AVAC celebrates 19 years of advocacy this World AIDS Day, we are proud of the work to date and are continually energized, and inspired, by the opportunities to work with so many remarkable individuals and organizations around the world.

We remain grateful to all of you for your support that allows us to reach further and faster on a wider range of issues than ever before. Your continued support is essential to our ability to convene, collaborate and communicate a strong and cohesive vision for HIV prevention today and to end the epidemic.

Today, as part of #GivingTuesday, a global day dedicated to giving back, we ask you to consider supporting AVAC’s work in one or more of the following ways:

Donate — Visit www.avac.org/donate.

Amazon Smile — Shop at Amazon.com? Visit smile.amazon.com and select AVAC as your charity of choice and a portion of your purchase price is donated to AVAC – at no additional cost to you!

US Combined Federal Campaign — If you are a US government employee, support our mission through the Combined Federal Campaign, CFC #12308.

Thank you for your continued support!