It’s time to plan for your participation at the 2021 HIV Research for Prevention Conference (R4P) Virtual, the only global conference focused exclusively on biomedical HIV prevention. The conference takes place over the course of four days, January 27-28 and February 3-4, and you can register here. Even if you’re not registered for the conference, there are ways to participate and follow the proceedings in real-time. Check out the Program at a Glance, and read on for how to join the discussions at the Advocates’ Corner and follow the conference using AVAC’s resources for real-time coverage.

• Advocates’ Pre-Conference
• Advocates’ Corner
• Real-Time Conference Coverage
• Sessions with AVAC and Partners
• Navigating R4P Virtual

Advocates’ Pre-Conference

The Advocates’ Pre-Conference, Community, Comrades and Connection, takes place the day before the conference begins, on January 26, 9-10:30am ET (click here to check the time in your region). This 90-minute session will help advocates prepare for the conference, with strategies for engaging with each other and mobilizing around timely issues. All interested HIVR4P registrants are welcome to join—from first timers to “old” timers. Register here.

Advocates’ Corner

Consider adding regular check-ins at the Advocates’ Corner to your R4P schedule. In the Corner, all are welcome in the exchange of ideas and the chance to network, build solidarity, relax and socialize—you do not need to be registered for the conference to participate in the Corner. The Corner features a series of pop-up conversations and learning labs designed to help advocates and civil society members dive deeper into the research presented during the conference. The corner will also offer “hallway huddles” with daily debriefs to unpack the news of the day, and breakout rooms to interact with colleagues. Check out the full schedule here.

Real-Time Conference Coverage

Look for conference round-ups via AVAC’s Advocates’ Network, follow AVAC on Twitter on @HIVpxresearch and the full conference via #HIVR4P. And finally we love aidsmap’s R4P news coverage—follow along for breaking news from the conference.

Sessions with AVAC and Partners

This collection of satellites, symposia and oral abstract sessions includes AVAC team members and partners confronting key issues on the frontier of HIV prevention science in 2021.

Wednesday, January 27

• Ethical considerations in HIV prevention trials: New guidance from WHO and UNAIDS
  
  12:15–13:45 (UTC) 7:15–8:45 am (ET)
• Late breaking trials at R4P, including results from HPTN 084 and the Antibody Mediated Prevention Trials
  15:00–16:00 (UTC) 10:00–11:00 am (ET)

Thursday, January 28

• Is perfect use the enemy of effective use?: Redefining success in the era of ARV-based prevention
  
  12:15–13:45 (UTC) 7:15–8:45 am (ET)
• Optimizing the delivery of HIV prevention services for maximum impact and sustainability: The Blantyre Prevention Strategy
  
  12:15–13:45 (UTC) 7:15–8:45 am (ET)
• PrEP is here, considerations to achieve continued use, with the latest data from our Global PrEP Tracker
  17:30–18:30 (UTC) 12:30–1:30 pm (ET)
• Mapping policy: Accelerating progress locally, nationally and globally, including presentations on our Advocates’ Trial Design Academy and the Biomedical Prevention Implementation Collaborative (BioPIC)
  
  17:30–18:30 (UTC) 12:30–1:30 pm (ET)
• The Future of PrEP: Developing its Potential from Research to Implementation, click here to see the agenda.
  
  18:45–20:15 (UTC) 1:45–3:45 pm (ET)

Wednesday, February 3

• Next-Generation Trial Design in Real Time: What’s at Stake
  12:15–13:45 (UTC) 7:15–8:45 am (ET)
• Beginning with the end in mind: What we (think we) know about prevention user preferences during It’s about people: Prevention in the real-world plenary session
  14:00 – 14:45 (UTC) 9am–9:45am (ET)
• Community engagement: Enabling responsive, inclusive, accountable research
  17:30–18:30 (UTC) 12:30–1:30 pm (ET)
• Vaccines: What HIV R&D did for COVID-19
  18:45–20:15 (UTC) 1:45–3:45 pm (ET)
• Advancing Novel HIV Prevention Strategies, Together: A Scientific and Community Exchange
  18:45–20:15 (UTC) 1:45–3:45 pm (ET)

Thursday, February 4

• Bringing PrEP to the people: Democratizing access to PrEP through differentiated delivery before, during and after COVID-19
  12:15–13:45 (UTC) 7:15–8:45 am (ET)

Many of the team and partners are also representing AVAC, CASPR and the Prevention Market Manager in posters and publications—click here and scroll to the last page for a full list.

Navigating R4P

To make the most of the sessions above, AVAC has a host of resources for you:

• Use AVAC’s conference Roadmap to navigate the conference.
• Visit the full R4P program here.
• Bookmark AVAC’s dedicated R4P page for a round-up of all these resources.

See you in the virtual hallways!

Today, Ambassador Deborah Birx announced that she would be retiring from leadership of the Office of the Global AIDS Coordinator and the US President’s Emergency Plan for AIDS Relief (PEPFAR). She also announced that her deputy coordinator, Angeli Achrekar, will be the acting US Global AIDS Coordinator. In this week of political transition—Joe Biden will be inaugurated as the 46th United States President tomorrow—AVAC marks Ambassador Birx’s departure with gratitude and a call to future action for PEPFAR and the new administration.

Under Ambassador Birx’s leadership over the past seven years, PEPFAR took critical steps to harness efficiencies in the program, increase transparency in data and ensure robust civil society engagement in planning and monitoring at country and global levels. These steps made the program stronger and delivered significant impact. AVAC and our partners have changed programs, policies and performance through data-driven demands often focused on PEPFAR.

AVAC looks forward to continuing our work to ensure that PEPFAR remains committed to data use, transparency and civil society engagement. Ensuring the continuation and expansion of PEPFAR is just one component of the robust US global health agenda needed to address COVID-19, build pandemic preparedness and drive towards epidemic control of HIV.

Last week, the Biden-Harris Administration announced plans for a US$11 billion global health investment and two health-focused positions on the National Security Council, as well as the appointment of human rights advocate and former US Ambassador to the UN Samantha Power as the next head of USAID. These are critical positions at a time of enormous consequences, and AVAC looks forward to helping to define an agenda that encompasses health security for all. Specifically, we look to the Biden-Harris Administration to:

• Act quickly to rejoin WHO and voice strong support for a US$4 billion contribution to the Global Fund and US$1 billion to PEPFAR. These multilateral and bilateral mechanisms have played a key role in getting funds to countries to strengthen and set up national pandemic responses; as COVID-19 cases creep up in sub-Saharan Africa and surge in many parts of the world, this emergency funding mechanism is out of funds. Failing to support countries shoring up their health systems, including surveillance, testing, treatment and vaccination systems, will prolong the pandemic globally and will lead to erosion of hard-fought past gains against HIV, tuberculosis and malaria.
• Sustain and expand support for PEPFAR. Prior to COVID-19, this singular American global health effort had helped drive rates of new HIV infections down by 40-50 percent in many of the countries where it worked. Its use of data, transparency about targets and results, focus on achieving epidemic control, and robust engagement with civil society based in the US and in the countries where it operated must continue. We look to the Biden Administration to ensure strong leadership of the program, which must stay in the State Department, with an empowered US Global AIDS ambassador, and a clear mandate from the White House to continue the critical work of AIDS treatment, prevention and care.
• Move swiftly on innovative, integrated, long-overdue restructuring of the US approach to global health and health security that coordinates and links investments in ongoing and point-in-time pandemics, and ensures preparedness for biowarfare attacks. Now is the time to develop a truly comprehensive health security agenda that clearly connects American investment in ongoing pandemics like HIV, tuberculosis and malaria, investments in preparedness and prevention of emergent pandemics like Ebola and COVID-19, and broad, country-driven investments like the Global Fund. A single coordinator of this effort, based at the White House and working closely across agencies and disease areas will be able to leverage the enormous expertise and assets of the US global health portfolio. This will help to ensure that the HIV-specific response not only succeeds at supporting countries to reach epidemic control, but also helps build the community-level trust in health systems, surveillance and laboratory capacity, and medications supply chains that will help prevent the next pandemic.

AVAC thanks Ambassador Birx for her service, and we look forward to working with the new administration in 2021 and beyond.

HIV R4P Virtual is coming right up, with events starting January 26th rolling through February 4th—don’t miss it. Held every two years, the HIV Research for Prevention Conference (R4P) is the only global conference focused exclusively on biomedical HIV prevention.

This year’s content will help set the stage for the high-stakes year ahead. Get started at the Advocates Pre-conference (click to register) on Tuesday, January 26th. Watch for AVAC’s updates from the meeting on social media and the Advocates’ Network, and bookmark AVAC’s R4P webpage so you can follow along.

The stakes are high for many reasons. COVID-19 is claiming lives across the globe, disrupting health care services and slowing the pace of HIV prevention and treatment research. At the same time, there are unprecedented opportunities to deliver both COVID-19 vaccines and new and emerging HIV prevention strategies. This virtual gathering, which includes access to the IAS COVID-19 Prevention Conference on February 2nd, is a chance to hear the latest data and explore the opportunities and challenges for research and rollout that lie ahead, including:

• Lessons from oral PrEP programs—and how they could accelerate the introduction of new long-acting options, like the Dapivirine Vaginal Ring and injectable cabotegravir.
• The latest research findings from interventions moving through the pipeline, such as the Antibody Mediated Prevention trials of a broadly neutralizing antibody, new forms of long-acting injectable and oral PrEP.
• The implementation science required to translate promising options into real choices and real impact.
• The innovations in new trial designs in the midst of PrEP rollout.
• The ongoing challenge to develop an HIV vaccine, an essential component to finally ending the epidemic.

And that’s just for starters… click here for our program at a glance to see what’s planned. In the coming days, watch this space and AVAC’s R4P page for a more detailed roadmap to guide you through the ins and outs of the conference at large; a rich program at the Advocates’ Corner; and in-depth details on conference highlights and featured sessions.

The Protecting Global Gains series kicks off 2021 with a story about the motivated and resourceful advocates in Bangladesh who not only safeguarded essential family planning services against the disruptions of COVID-19 but also maximized the impacts of domestic investment. Read on for the latest edition of Protecting Global Gains: Bangladeshi activists help sustain access to family planning services.

In April 2020, the Guttmacher Institute released dire estimates on how COVID-19 is affecting sexual and reproductive health services. Estimates showed that the compounding ramifications of national lockdowns, economic losses, disrupted supply chains, and repurposed health personnel could lead to as many as 15 million annual unintended pregnancies in low- and middle-income countries. Sexual and reproductive health services in Bangladesh experienced some of these challenges—especially as personal protective equipment (PPE) was allocated to staff providing essential health services only.

Advocacy groups and local governments in Bangladesh took action in response to this sexual and reproductive health emergency. Learn about how two Bangladeshi NGOs, Marie Stopes Bangladesh and Shushilan, through the Advance Family Planning initiative, worked with local government to stave off feared setbacks in reproductive and sexual health in the latest story on protectingglobalgains.org, Bangladeshi activists help sustain access to family planning services.

Whether it’s resuming polio vaccinations in remote areas of Pakistan, introducing smarter ways to distribute bed nets in Benin, or safeguarding reproductive health in Bangladesh, community ownership and local innovation have been key to building flexible and resilient health systems and staving off the worst of the COVID-19 pandemic.

Follow the Protecting Global Gains series on social media at @hivpxresearch, @theglobalfight, @Amref_Worldwide and #ProtectingGlobalGains, and consider amplifying these stories on your own social media. Advocates can pressure governments to honor their commitments to family planning services and for continued national and global investment in efforts to minimize the toll of COVID-19 on sexual and reproductive health. Visit www.protectingglobalgains.org to learn more about how to take action.

2020 was, by any measure, a difficult year. A year ago, a pandemic with the magnitude of COVID-19 was, for many, unimaginable. At AVAC, we have sought to respond to all of the events of 2020, from the COVID pandemic to the ongoing fight for racial justice and free and fair elections in so many countries, including the United States. We are proud to work with partners who share and strengthen our commitment to secure long-term gains in HIV, sexual and reproductive health and rights, and equitable access to health with a social justice lens.

In this first week of the New Year, we at AVAC are committing to continue and expand this work. We make this commitment against a backdrop of an escalating pandemic, of inequities in COVID-19 vaccine access, and of continued stress on health systems that are leaving millions around the globe at risk from other health issues. And we make this commitment during a time of division, dishonesty, insurrection and hatred in the United States—all instigated and incited by a delusional president, aided and abetted by people who were meant to be public servants, but who have clearly abdicated their stated commitments to democracy.

The world watched the events of January 6th in Washington, DC, with shock and horror. AVAC’s US-based staff are grateful for the many messages of concern and solidarity from friends and partners around the world. We don’t know what will happen with the US government in the coming days, but are confident that on January 20th, a new administration will take office. And we celebrate the results from two free and fair Georgia Senate races, delivered in the face of manipulation, fear and intimidation.

AVAC looks forward to engaging with the incoming Biden-Harris Administration to ensure more equitable US domestic and global health policies. We will do this as part of our continued work with partners across the globe.

Twenty-five years ago, a group of activists came together to form AVAC in the face of another pandemic and in the certainty that a small group of committed people could call out governments and other institutions for their inadequate and unjust responses. Today we stand on their shoulders and side by side with advocates around the globe calling for health equity, justice and human rights.

As we look to the future, we welcome your thoughts and ideas for our joint work in the year to come.

Do you know a courageous and inspiring young activist, advocate or community engagement worker who impressed and inspired you in 2020? Someone who innovated to ensure that research continued safely despite COVID-19? Someone who advocated to ensure that HIV treatment, care and prevention did not stop? Someone who shone a light on human rights violations, or who demanded that community voices help shape the response? Consider nominating them for this award! Submission deadline is January 4. Learn more at www.avac.org/falobi.

As 2020 comes to an end, we hope this finds you in a place that allows for rest, rejuvenation and reflection. In a profoundly challenging year, we at AVAC draw strength from all of our allies and partners and have a renewed sense of gratitude—for the dynamic leadership of civil society, for the power and promise of scientific inquiry, for evidence-based decisions, and for voters who support democratic principles. We know 2021 will bring new challenges, new choices and new clarity. And now more than ever, we need to be strong, prepared and resilient.

In a world turned upside down by another global pandemic and economic recession, and with support from all of you, we have seen how essential it is for advocacy and health systems to ensure we protect global gains against HIV and other health threats, even as COVID-19 disrupted supply chains and access to care.

We have joined our partners in an extraordinary effort, engaging researchers, regulators and communities to build a global response to COVID-19 based on equity and to build a movement for pandemic preparedness.

And, in the midst of it all, we have witnessed landmark strides in the development of additional HIV prevention options.

This resilience must deepen and expand in 2021—COVID-19, HIV, siloed-responses, vaccine nationalism and inequitable access are not over, far from it. In the days to come, we at AVAC hope you will rest, rejuvenate and prepare, because in 2021 the world will need your fierce voices and actions more than ever.

To help prepare, we’ve gathered below AVAC resources to support our collective work in 2021. And to help us, if you can, please consider a contribution to keep this work moving by visiting www.avac.org/donate.

Reading and Resources for the Holidays and Beyond:

• For a quick, sharp take on where HIV prevention advocacy is headed in 2021, read AVAC’s Dear World letter.
• Listen to CAB-LA is Highly Effective; Now what, our latest Px Pulse podcast exploring the early results from trials testing cabotegravir as a long-acting injectable PrEP. The podcast also takes up what comes next in planning for the rollout of CAB-LA alongside oral PrEP and the Dapivirine Vaginal Ring. And check out a host of resources on the dedicated CAB-LA page.
• Listen to A Leap Forward For The Dapivirine Vaginal Ring, the Next Steps Are Critical, our podcast featuring five perspectives in on next steps for the ring. For a deeper dive, check out Understanding the EMA Opinion and Next Steps for the Dapivirine Vaginal Ring.
• Check out new resources on Antibody-Related Research, particularly Amp-ticipation: Context and concepts for understanding the AMP Trials, a blog by AVAC co-founder Bill Snow.
• Designing a New Generation of Prevention Efficacy Trials, also by Bill Snow, lays out basic concepts in innovations in trial design and an analysis of the implications for advocacy.
• Women and Girls at the Center is a joint initiative between AVAC and FP2020 and features resources to champion the integration of sexual and reproductive health with HIV prevention and treatment. Download a webinar, One Year After ECHO: Innovation in the time of COVID, and find links to a host of resources to inform your advocacy.
• A Dynamic New Global PrEP Tracker provides a whole new way to visualize and explore the data from our Global PrEP Tracker, a database that documents oral PrEP uptake around the world.
• Advocate’s Guide To COVID-19 Vaccine Access is a plain-language guide on the necessary components for equitable access to a COVID-19 vaccine.
• Cheat Sheet: COVID-19 Vaccine Pipeline provides an at-a-glance view of the funders, platforms, research phase and considerations for some of the front-runner candidates.
• Protecting Global Gains is a partnership of Amref Health Africa, AVAC, and Friends of the Global Fight Against AIDS, TB and Malaria that documents innovative solutions to the impact of COVID-19 on health programs all over the world.
• Why exciting results from vaccine research are just the beginning of efforts to end COVID-19, a Devex op-ed, written by AVAC’s Mitchell Warren, focuses on lessons from HIV to ensure effective COVID-19 vaccine becomes accessible to the people who need it.
• For our last word in 2020, we invite advocates, activists, supporters, allies and friends to share in our celebration of two remarkable achievements this year: AVAC’s 25th year as a champion for HIV prevention research, and the 10th year of AVAC’s extraordinary Fellows Program. Click through to see a timeline of growth and impact for AVAC at large, and explore this report to learn more about the strength and reach of the Fellows Program.

There will be no issue for the next two weeks. The NewsDigest will return on January 8, 2021. Our best wishes for happy holidays and a peaceful new year, and our thanks for reading!