Research Fundamentals: What is partial protection?

AVAC is launching a new series on our podcast Px Pulse—Research Fundamentals. In addition to our regular schedule of programs covering advances and challenges in HIV prevention research, Research Fundamentals we’ll explore scientific concepts in research, one at a time.

In our debut episode we explore the concept of partial protection, with:

  • David Evans, science and advocacy consultant for AVAC, formerly of Project Inform
  • Penny Moore from South Africa’s University of the Witwatersrand and National Institute for Communicable Diseases
  • And Sandhya Vasan of the US Military HIV Research Program

Together we explore the meaning of partial protection. Whether it’s condoms, a flu shot, oral PrEP or the dapivirine vaginal ring, proven products fall short of 100 percent protection against disease, and there’s a lot to know about how and why an intervention may offer imperfect but still useful protection.

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Integration of HIV prevention and SRH services in Zimbabwe

Findings from an assessment of HIV prevention and SRH integration in Zimbabwe, conducted in collaboration with the Ministry of Health and Child Care, comprised of site visits to health facilities, key informant interviews, civil society dialogues and a policy review.

Advocates’ Primer on Injectable Cabotegravir for PrEP: Trials, Approvals, Rollout and More

Results from two large-scale efficacy trials found that injectable cabotegravir (CAB-LA), given every two months, was effective as a form of pre-exposure prophylaxis (PrEP) in preventing HIV in gay men and other men who have sex with men, transgender women who have sex with men, and cisgender women. CAB-LA was developed by ViiV Healthcare and is currently used in HIV treatment. It was approved by the US Food and Drug Administration (FDA) as the first form of injectable PrEP in December 2021. This document focuses on CAB-LA for prevention, outlining what’s known and what’s next for this emerging biomedical HIV prevention strategy.

COMPASS

Since 2017, the Coalition to Build Momentum, Power, Strategy and Solidarity has broken new ground in transnational HIV activism that’s grounded in rigorous analysis, fearless tactics and collaboration across geographies. We’re winning commitments and changes that will drive epidemic control. Read on to see what the future of AIDS activism looks like.

A Collaborative Approach to HIV Prevention Product Introduction

The HIV prevention product pipeline offers exciting potential to curb HIV incidence. But we know from previous products that translating trial efficacy to population impact is challenging without coordinated effort.

The Intersections of HIV and COVID-19 in Real-Time

As the COVID-19 pandemic rages on across the world, the latest crisis is markedly reminiscent of the early days of HIV. And while the HIV epidemic is far from over, unrelenting activism, strong community engagement, partnerships and innovation are to thank for the strides the field has made towards controlling the epidemic.

Now, the response to COVID-19 is drawing heavily from these successes, and at the same time, forcing even more innovation on the HIV front.

In this episode of Px Pulse, we’ve compiled excerpts from two April webinars that offer unique perspectives on how COVID-19 and HIV are shaping one another. First, Mark Feinberg, CEO of IAVI, and Helen Rees, Executive Director of the Wits Reproductive Health and HIV Institute (Wits RHI), speak to COVID-19 vaccine development, and the role of the Coalition for Epidemic Preparedness Innovation (CEPI) in spurring vaccine funding and collaboration. We then turn to community engagement experts Sinead Delany-Moretlwe, Director of Research at Wits RHI, Vincent Basajja of the Uganda Virus Research Institute, Jau Nanyondo from Uganda’s Makerere University Walter Reed Project and Philister Adhiambo from the Kenya Medical Research Institute, who explain how HIV prevention trials are adapting in the wake of COVID-19.

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Applying Lessons from Family Planning to HIV Prevention Product Introduction

An analysis of lessons and data from family planning in sub-Saharan Africa to better inform introduction of HIV prevention products and integration of HIV prevention into family planning settings.

Integration of HIV Prevention and Sexual Reproductive Health Services in Kenya

Findings from an assessment of HIV prevention and SRH integration in Kenya, conducted in collaboration with the Ministry of Health, comprised of site visits to health facilities, key informant interviews, civil society dialogues and a policy review.

HIV & Sexual and Reproductive Health Integration

Compilation of top learnings on and approaches to implementing HIV/SRH integration in sub-Saharan Africa, drawn from literature reviews, qualitative interviews, and an analysis of policy requirements for PrEP and family planning providers.

Exploring Integration of Family Planning and HIV Services

A literature review to identify existing knowledge on barriers and enablers to the integration of HIV and family planning services in sub-Saharan Africa, in order to understand the feasibility of providing existing and new HIV prevention options and services in family planning settings.