Avac Event
Local production has emerged as an essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. This webinar will explore how might local manufacturing and the new mRNA Hub in South Africa facilitate access and support R&D.
Featuring Petro Terblanche of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group.
Recording / Caryn Fenner Slides / Mike Frick Slides / Ike James Slides
May 17, 2023
With several large HIV vaccine trials in the last few years finding no efficacy, the field is in transition. There are diverse ideas in vaccine research, but there’s no clear concept that’s ready to test in a late-phase trial or move towards product development currently. Researchers are back to testing new ideas in early phase research.
In this episode of our Px Pulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?, Dr. Katy Stephenson explores the implications of recent trial results, the big questions driving next generation vaccine development, and new strategies underway in early phase research. Katy is a doctor, a researcher, a professor of medicine at Harvard Medical School, affiliated with Beth Israel Deaconess Medical Center, and part of the Center for Virology and Vaccine Research.
In 2023, AVAC and CASPR partners cast a spotlight on many issues and opportunities for HIV vaccine science. This one-pager highlights key conversations.
Avac Event
Join AVAC and partners for the biennial International Conference on AIDS and Sexually Transmitted Infections (ICASA), in Harare, Zimbabwe December 4-9. More than 30 of our partners will convene at the meeting to champion community leadership and amplify their role in shaping local, national and global responses and delivering impactful advocacy. Community leadership on a range of issues are instrumental to:
Scroll down for a roadmap to ICASA’s prevention program, and details on sessions and events that you won’t want to miss.
Tuesday, December 5
Wednesday, December 6
Thursday, December 7
Friday, December 8
In this round up of updates and resources, you’ll find a read-out of the May UNAIDS high-level meeting in Geneva, two webinars that spotlight critical issues for vaccines R&D and the potential of broadly neutralizing antibodies, and an upcoming webinar looking at alternatives to long-acting PrEP. Read on and join us!
The HIV Response at UNAIDS High-level Meeting
A high-level meeting in Geneva, held by UNAIDS last month on the margins of the World Health Assembly, brought together advocates and experts through the Global HIV Prevention Coalition to discuss where action is needed most to bolster HIV response and advance global health equity. Read AVAC’s summary of the meeting in our latest P-Values blog.
Vaccines in 2023 and Beyond
AVAC hosted two webinars in commemoration of HIV Vaccine Awareness Day. They offer a snapshot on the state of the field for an HIV vaccine, and explore considerations for the development and delivery of vaccines against future pandemics. Check them out below and read more in our HVAD one-pager!
What’s All the Buzz About: mRNA, manufacturing, vaccines access Local production has emerged as an essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. This webinar explored how local manufacturing and the new mRNA Hub in South Africa could facilitate access and support R&D. Check out the summary and recording.
To bNAb or not to bNAb? The case for broadly neutralizing antibodies AVAC and partners explored the potential role of bNAbs in prevention, the status of research and development, and implications for HIV vaccine research. Check out the summary and recording.
Upcoming
PrEP In Black America Presents Mpox Webinar
PrEP in Black America alongside a panel of experts will discuss the impact of mpox on Black communities, advocacy and mobilization to keep our communities safe, and information on vaccine effectiveness. Tuesday, June 20 at 2:00 PM to 3:30 PM ET. Register here.
PrEP That Booty: The latest on rectal microbicide research for the back door
Most of the coverage of the HIV prevention pipeline is about long-acting, longer-acting, and even longer-acting products that deliver drug throughout the body and require a trained clinician to deliver. However, these attributes are not desirable to many folks, and communities want a range of choices. Learn more about the alternatives at this webinar. Thursday, June 29 at 9:00 AM to 10:30 AM ET. Register here.
May 18th is recognized as HIV Vaccine Awareness Day (HVAD), and this year it is a time of deep reflection and potential. Three major HIV vaccine trials have ended in no efficacy since 2020, but the field knows more than ever that a vaccine is still needed for a durable and sustainable end to the pandemic – and has new insights into possible vaccine strategies that might one day effectively protect against HIV.
This year, AVAC and CASPR partners are casting a spotlight on the many issues and opportunities for HIV vaccine science. See below for three important conversations
Podcast: Listen to AVAC’s PxPulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why, featuring Katy Stephenson of Harvard Medical School, Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research. In conversation with AVAC’s Jeanne Baron, Katy provides an accessible breakdown on the status of the field of HIV vaccine research, including details on recent trial results that proved ineffective and what’s next (and exciting) in HIV vaccine advocacy and research.
“The field needs to expand the diversity of scientists who are thinking of new ideas. We haven’t gotten far with the ideas coming out exclusively from the United States and Europe. We need to bring in young scientists of diverse backgrounds all over the world to think of ideas we can’t even imagine.”
“We now know that non-broadly neutralizing antibodies don’t work, but broadly neutralizing antibodies can work. It’s a big milestone in the field to have that kind of knowledge now.”
Katy Stephenson, Harvard Medical School and Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research
Webinars: AVAC brought together partners, advocates and other experts for two vaccine webinars. The first, on local manufacturing production, takes on this essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. The second explores the development of broadly neutralizing antibodies (bNABs) and their potential in HIV prevention. Check out the recording and slides for both.
What’s All the Buzz About: mRNA, manufacturing, vaccines access – featuring Caryn Fenner of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group.
“LMICs (Low- or Middle-Income Country) are not only the consumers of IP (Intellectual Property), we are the generators of IP!” Caryn Fenner, Afrigen Biologics
“It’s important for us in the Global North to know that vaccine technology didn’t start in Global North and was often taken from others.” Mike Frick, Treatment Action Group.
“Engagement and commitment [is needed], not only when a pandemic exists, but long-term commitments are key to follow through on.” Ike James, Medicine Patents Pool
To bNAb or not to bNAb? The case for broadly neutralizing antibodies – featuring Slim Abdool Karim of CAPRISA, Pervin Anklesaria of Bill & Melinda Gates Foundation, Khadija Richards of Wits RHI, and Huub Gelderblom of HIV Vaccine Trials Network (HVTN).
“The scientific complexities of bNAbs require a more attuned focus on community engagement… And it will require a high degree of validating [people’s] lived experience.”, Khadija Richards, Wits RHI.
“The hope is that if bNAbs are effective in prevention, they create a pathway towards a vaccine.” Slim Abdool Karim, CAPRISA
“To close the gap between scientific innovation and globally accessible and affordable bNAb combination products…we certainly need innovation in manufacturing. It is a long-term process and it’s not going to happen overnight. But we do need to start now.” Pervin Anklesaria, Bill & Melinda Gates Foundation
“What I see is actually multiple modes of PrEP available, and then people can make choices depending on what works for them.” Huub Gelderblom of the HIV Vaccine Trials Network on the potential of bNAbs as PrEP
AVAC and partners hosted a conversation to explore the potential role of bNAbs in prevention, current status in the field, and key issues to consider in HIV vaccine research.
Panelists included: Slim Karim, CAPRISA, Pervin Anklesaria, Bill & Melinda Gates Foundation, Khadija Richards, Wits RHI, Huub Gelderblom, HIV Vaccine Trials Network (HVTN)
Hosted By: Mitchell Warren, AVAC and Stacey Hannah, AVAC
Recording / Slim Karim Slides / Pervin Anklesaria Slides / Khadija Richards Slides / Huub Gelderblom Slides
May 18th is recognized as HIV Vaccine Awareness Day (HVAD), and this year it is a time of deep reflection and potential. Three major HIV vaccine trials have ended in no efficacy since 2020, but the field knows more than ever that a vaccine is still needed for a durable and sustainable end to the pandemic – and has new insights into possible vaccine strategies that might one day effectively protect against HIV.
This year, AVAC and CASPR partners are casting a spotlight on the many issues and opportunities for HVAD 2023. Check it all out here! And read on for details about a wide range of new resources.
Listen to the newest PxPulse podcast, “Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why,” featuring Katy Stephenson of Harvard Medical School, Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research. In conversation with AVAC’s Jeanne Baron, Katy provides an accessible breakdown of where the field of HIV vaccine research is, including details on recent trial results that proved ineffective and what’s next (and exciting) in HIV vaccine advocacy and research.
Thursday, June 1 at 10am ET / 4pm SAST
Featuring Caryn Fenner of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group. Register here.
Wednesday, June 7 at 10 AM ET / 4 PM SAST
Featuring Slim Abdool Karim of CAPRISA, Pervin Anklesaria of Bill & Melinda Gates Foundation, Khadija Richards of Wits RHI, and Huub Gelderblom of HIV Vaccine Trials Network (HVTN). Register here.
Communities across the globe will be engaged in a wide array of events focused on HIV vaccine awareness in the coming days. Here, we provide details on activities the Coalition to Accelerate & Support Prevention Research (CASPR) partners are leading – be sure to watch AVAC’s Twitter for real-time highlights!
In the weeks to come, we’ll release From the Lab to the Jab, a series of briefs on next generation vaccine research and development; the basics of mRNA technology; initiatives that support local manufacturing; and understanding and overcoming barriers that undermine equitable access to vaccines. Each brief also highlights the advocacy needed to keep these efforts on track and in line with what communities need and want.
AVAC has updated our recent HIV vaccine primers. And we’re sharing a viewpoint written in the Journal of the International AIDS Society.
As the science continues to advance, we hope these resources inform our collective advocacy. With the knowledgeable voices of advocates guiding the response, scientific successes will not be squandered, communities won’t be left behind, programs will be people-centered, and epidemics will end.
Produced and hosted by Jeanne Baron
With several large HIV vaccine trials in the last few years finding no efficacy, the field is in transition. There are diverse ideas in vaccine research, but there’s no clear concept that’s ready to test in a late-phase trial or move towards product development currently. Researchers are back to testing new ideas in early phase research.
In this episode of our Px Pulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?, Dr. Katy Stephenson explores the implications of recent trial results, the big questions driving next generation vaccine development, and new strategies underway in early phase research. Katy is a doctor, a researcher, a professor of medicine at Harvard Medical School, affiliated with Beth Israel Deaconess Medical Center, and part of the Center for Virology and Vaccine Research.
In 2023, AVAC and CASPR partners cast a spotlight on many issues and opportunities for HIV vaccine science. This one-pager highlights key conversations.