From Brisbane to Chicago: A look at STIs, HIV and global health

Late July saw two nearly simultaneous conferences on the future of research and advocacy for HIV and sexually transmitted infections (STIs). IAS 2023 in Brisbane and the 2023 STI and HIV World Congress (also known as ISSTDR) in Chicago are landmark annual events. Both conferences bring together civil society, advocates, policy makers, donors and scientists to share the latest scientific findings and discuss where advocacy is needed to both advance research and ensure equity informs every aspect of the development process, from basic science to delivering new interventions. There may be two gatherings, but it’s one vital conversation. HIV and STIs are inextricably linked, affecting the same communities, who face the same barriers to care and prevention against these health threats. At AVAC, we see the links and we are making the connections. Below we offer highlights from these two all-important world gatherings, and check out our recent webinar linking these conversations, Tales from Two Cities: HIV and STI research highlights from Brisbane and Chicago.

AVAC at IAS

Taking prevention to the next level: Packaging PrEP with primary health care services as a pathway to achieving 2030 HIV prevention and universal health coverage goals

This satellite, co-sponsored by PATH, IAS, WHO and AVAC, put a spotlight on integrated, person-centered care, a central theme of the 2023 UNAIDS report launched at IAS 2023, The Path That Ends AIDS. UNAIDS reports that investing in person-centered priorities such as community-led services, integrating primary health care with HIV services, and a strong health workforce brings down incidence. And the pressure to scale up these approaches remains essential. According to the latest statistics in the report, only 42% of districts in African countries with very high HIV incidence are covered by prevention programs. Even more chilling, 4,000 adolescent girls and young women acquire HIV every week.A presentation in this session by former AVAC Fellow and CASPR partner Chilufya Kasanda from Zambia’s TALC put a face and a voice to this story. In Zambia, youth friendly services are scarce or non-existent, high rates of mental health issues are utterly neglected, and donors “flock to a few locations and leave out those who are most in need.” She said community advocates are too often dismissed as “people just making noise.” But, said Chilufyia, it’s young people who must receive support, their leadership must be nurtured and funded, and messages should be tailored just for them. “Young people need to know that pleasure, not only risk, is attached to sex. To get to pleasure, you need to be safe, that is the message.” Another AVAC Fellow, Elizabeth Onyango from Kenya’s Coast Sex Workers Alliance, called for accelerating access to the dapivirine vaginal ring. “Why is the ring not in our vaginas? Male condoms even come in different flavors! This is a women-first product and it needs more investment.”    

Regaining lost ground for HIV prevention: Acting on lessons learned from oral PrEP scale-up new PrEP method mix

Prevention will fail if the HIV response remains narrowly focused on products. Oral PrEP has brought invaluable lessons we have yet to learn about how to get programming right so that effective products actually reach those who need them. As AVAC Executive Director Mitchell Warren said at the conference, reflecting on the status of PrEP uptake since FDA approval in 2012- “Only 4m global PrEP initiations in 12 years is an epic failure. Science has given us products that work, but our policies and programs have failed to meet the needs.”

This session featured presentations from AVAC on a package of tools called, Getting Rollout Right and the work of the Coalition to Accelerate Access to Long-Acting PrEP. Daniel Were of Jhpiego talked about lessons from the Jilinde project, Kenya’s ambitious program to deliver PrEP.  The project adapted in real time to reach more people by recognizing that peer networks are essential, that stopping and starting PrEP is common, and that provider attitudes can be difficult to change. Daniel stressed the importance of focusing deeply on the people who need to use these products. 

HIV Cure & Immunotherapy Forum

This preconference forum on HIV cure research featured innovative presentations tracking the progress toward an HIV cure. AVAC Senior Program Manager Jessica Salzwedel participated in a panel discussion on the importance of increasing diversity throughout HIV cure research from trial participants, to advocates, to researchers. The session also featured the release of a new resource on community preferred language for HIV cure.

bnAbs: From prevention to cure

This session covered the potential for research on broadly neutralizing antibodies (bNAbs) to inform strategies for both prevention and cure. AVAC partner Maureen Luba joined the panel discussion to applaud collaboration among the bNAb researchers working in prevention and cure, and she called for the same collaboration with communities. She said research budgets for community engagement should reflect the importance of community leadership right from the beginning, to ensure success in the future. Maureen added “thinking about cost and choice is the elephant in the room. The resource envelope for HIV prevention is not expanding enough. Countries will be asking ‘where will we get the money [for bNAbs].’ We have to think about cost effectiveness now.”

Next Gen HIV Prevention research: Clinical Trials in an era of highly effective standards of care

Investigators and advocates discussed innovative methods to test how new interventions compare to oral PrEP, and how to also make comparisons to HIV incidence in a given community. Models of community engagement were just as important in the conversation. Ntando Yola of APHA described robust programs that brought community members along as these complex new trial designs were developed. Investing in Good Participatory Practicemeans investing “in the platforms that equip and empower communities and advocates,” said Ntando. And for more on how trial design is evolving, check out AVAC’s Evolving Designs for HIV Prevention Trials.

AVAC at the STI & HIV World Congress

The STI Prevention Pipeline: Where Are We, and What Will It Take to Move Forward Faster?

This session on the state of the field offered updates on how STI prevalence and incidence rates are estimated, STI vaccine acceptance, STI test development, and information on the first US STI National Strategic Plan and Federal Implementation Plan. The session included discussions about advocacy priorities in each of these areas, with discussions continuing in the Advocacy Zone throughout the conference (see below). For more on the STI pipeline, check out the resource pages on STIwatch.org.

Setting Up a Remote/Home Testing STI Programme: A Practical Toolkit

This session explored the power of remote testing to curb STI acquisitions. Remote and home-testing brings many benefits. It’s convenient, overcomes barriers from stigma, offers privacy, reflects trauma-informed principles, and can overcome structural barriers. For the status of testing for several STIs go to the pathogen pages on STIwatch.org.

Symposium: New Vaccine Approaches to STI Prevention, STI Vaccine Acceptance, and Equity

This symposium shared progress on STI vaccine research and examined the question, “what factors could influence acceptance of STI vaccines and how do we ensure equitable access to these vaccines”. AVAC’s Dr. Alison Footman referenced the disparities in the COVID-19 vaccine and how vaccine access can differ due to income, health insurance, and region. Considerations around equity, access, vaccine hesitancy, vaccine confidence, and vaccine awareness must be confronted as an integrated part of the advocacy for STI vaccine development. This session provided a platform for framing these issues and developing an agenda for advocacy.

ISSTDR Advocacy Zone

AVAC hosted an Advocacy Zone at the conference, which bubbled with activity throughout the meeting. Advocates used this space to weigh in on questions and share perspectives on how the STI field can grow and how advocacy can equitably advance the field. Overall themes included the need to normalize sexual health, center pleasure in STI conversations and the urgency for increased funding to support STI prevention and research.

Spotlight on WHO News at Both Conferences

The WHO made headlines from Brisbane and Chicago, with major announcements and research findings that will be shaping global health for years to come.
 U=U and Zero Risk

In a policy brief released at IAS 2023, the WHO directly affirmed zero risk of HIV transmission from people living with HIV who have an undetectable viral load using any WHO-approved test and who adhere to treatment. The brief, The role of HIV viral suppression in improving individual health and reducing transmission, also emphasizes the importance of expanding viral load testing, particularly in low and middle-income countries (LMICs) where access to testing falls far short of the need. The Lancet also published the WHO’s systematic review of the data behind this finding, championed since 2016 by the U=U campaign (undetectable=untransmittable).

A Call to Expand HIV Self-testing

Also from Brisbane, the WHO announced new HIV testing guidelines, calling for countries to expand use of HIV self-testing (HIVST) and to promote testing through social networks. In a July 22 press release, the WHO said, “These recommendations are issued at a moment of unique opportunity, when self-care and self-testing are increasingly being recognized as ways to increase access, efficiency, effectiveness and acceptability of health care across many different disease areas, including HIV.”

Surveillance of Mpox

The WHO presented their mpox surveillance data in Brisbane, building on findings reported at the Conference of Retroviruses and Opportunistic Infections that showed mpox severely impacts people living with HIV (PLHIV) who have a very low CD4 T-cell count. The WHO analysis draws from a larger set of data than was presented at CROI, and it found PLHIV with advanced immunosuppression were twice as likely to be hospitalized than people who are HIV-negative. See the aidsmap article for details.

Guidance on STIs

WHO called for better access to testing and diagnostic services at the STI & HIV World Congress. Its new guidance on testing and diagnostics includes: target product profiles (TPPs) for point-of-care tests for STIs, to diagnose syphilis, chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis; and an updated edition of The diagnostic landscape for sexually transmitted infections featuring tools to scale up screening for syphilis, chlamydia, gonorrhoea, trichomoniasis, mycoplasma, herpes, and human papillomavirus (HPV) in LMICs. Earlier this year, the WHO approved its multi-year implementation strategy for HIV and STIs. For more information on the status of diagnostics and vaccines for STIs, go to STIwatch.org.

HIV Research Highlights

Women Want CAB for PrEP as a Choice in HIV Prevention

Researchers presented findings from the open label extension study of HPTN 084 studying injectable cabotegravir (CAB) for PrEP, among individuals born female. Among 2500 participants in seven African countries, nearly 78% chose injectable CAB and 22% preferred oral PrEP. And a related study, HPTN 084-01, also found CAB for PrEP was generally acceptable to a small study of cisgender adolescent women in a study conducted in South Africa, Uganda and Zimbabwe. 92% opted to continue use of CAB for PrEP in the open label extension. The study also found that engagement of parents or guardians could be pivotal, providing young women with the support they need to make choices with confidence. The HPTN’s Erica Hamilton said the study reinforces how much choice matters. “The efficacy of CAB for PrEP was reassuring, but some participants still preferred the oral tablet [which also has very high efficacy] for various reasons.”

New Data on VMMC Among Gay Men and Other Men Who Have Sex with Men (MSM)

A small but noteworthy study from eight cities in China showed VMMC offered protection against HIV transmission among MSM. Researchers say this first randomly controlled trial demonstrating efficacy among MSM should be followed up by larger trials.

Tracking the Inclusion of Transgender People in Research

The launch of AVAC and the Office of HIV/AIDS Network Coordination’s (HANC) Clinical Trial Scoring Tool, provided an initial analysis of the inclusion of transgender people in HIV research and a tool for tracking inclusion in the future. This tool generated great excitement during the poster session. The score card evaluating HIV research since 1991 found less than 1% of participants in 41 key HIV studies included transgender populations. “Dozens of attendees from Harare to Montreal to Hyderabad had questions and expressed interest in using the scorecard and applying it to other populations, too.”

Cure at IAS 2023


The “Chicago Patient” was first presented at CROI 2023 and is the first known case of rebound from a bone marrow transplant where the donor did NOT have a critical and rare mutation to what is called the CCR5 receptor, which is found on certain human immune cells. The individual decided to go back on therapy after two consecutive detectable viral loads. This case is interesting because it suggests that reservoir cells may persist even after extreme clearance measures that are part of a stem cell transplant.
 
The “Geneva Patient” is the potential sixth cure for HIV. This individual received a bone marrow transplant from a donor with wild type CCR5 — meaning they did not have natural immunity to HIV. The individual experienced severe graft vs. host disease, a complication where the new immune system attacks the host. No virus can be found 20 months off therapy using the most sensitive assays. The medication used to stop the effects of graft vs. host disease promotes latency, meaning the reservoir cells have a harder time reactivating. Researchers are excited about this case because it provides clues on the role of the immune system in clearance and potential pathways toward an HIV cure. 
 
The 5 cases of pediatric control were presented by Gabriela Chaumet of University Kwa Zulu-Natal. This longitudinal study followed 281 mother-infant pairs with in utero transmission. The children were started on ART soon after birth and about 92% were exposed to ART in utero through the placenta. Five of the children, all male at birth, who were not adherent to ART were able to control the virus below detectable levels without therapy. However, Only 40% of the infant cohort was male. The study suggests the importance of the virus itself and indicates the need to further understand the impact sex & gender may have on future HIV cure strategies.

STI Research Highlights

GPP on the STI Map

From two different sessions in Chicago, a GPP champion and San Francisco’s Bridge HIV medical director Dr. Hyman Scott called out the power of Good Participatory Practice. In sessions on Biomedical Prevention for STIs and HIV and Addressing the HIV and STI Syndemic, Hyman’s presentations called for GPP to be implemented broadly. “I am really glad to see AVAC at this conference. We need GPP to hold us accountable,” said Hyman. CASPR partner Zinhle Sokhela of Wits RHI also gave background on GPP during the session Centering Equity, Inclusion and Diversity in STI/HIV Research and referenced a Cameroon and Cambodia PrEP trial that ended prematurely due to lack of effective community engagement. “The [GPP] guidelines help prevent misunderstanding and miscommunication among researchers and stakeholders.”

Antimicrobial Resistance and New Drugs in the Pipeline

Resistance to existing antibiotics for different STIs is spurring a hunt for alternative drugs. The conference presented encouraging early findings on new interventions for herpes simplex virus (HSV) and mycoplasma genitalium (M. genitalium), which cause urethritis and other diseases. A retrospective review of data from 165 patients found minocycline cured 2/3 of the resistant cases of M. genitalium. Phase II studies of pritelivir demonstrated superiority over the standard of care for resistant cases of HSV.

Women and DoxyPEP

Dr. Jenell Stewart presented additional data on the DoxyPEP study out of Kenya and found, from hair testing analyses, that 44% of women assigned to DoxyPEP may have not taken any of the medication. This could be one reason why DoxyPEP has not shown efficacy among women, from data that was previously presented at CROI 2023. Watch this space for more data coming out of the D-PEP Kenya study, including a look at the correlation between PrEP and DoxyPEP adherence, as well as conversations about future research of DoxyPEP in cisgender women.  

The Promise of Self-Testing

A presentation by Preventx, a UK-based supplier of self-testing kits, featured their analysis that remote/home-testing led to the diagnosis of a similar number of STIs as those diagnosed in the clinic. Preventx shared that out of 2.2 million kits ordered over a given period of time, they saw a high rate of return, with 1.8 million kits returned.

This cross section of research, advocacy and innovation in STIs and HIV should be a call to action for all of us who see how equity and sexual health cannot be siloed.

P.S. In case you missed it, AVAC recently launched the latest HIV Prevention and Cure Resource Tracking Reports. Find all the details here.

Avac Event

To bNAb or Not to bNAb? The case for broadly neutralizing antibodies

Join AVAC and partners for a conversation to explore the potential role of bNAbs in prevention, our current status in the field, and key issues to consider in HIV vaccine research.

Panelists: Slim Karim, CAPRISA, Pervin Anklesaria, Bill & Melinda Gates Foundation, Khadija Richards, Wits RHI, Huub Gelderblom, HIV Vaccine Trials Network (HVTN)
Hosts: Mitchell Warren, AVAC and Stacey Hannah, AVAC

Recording / Slim Karim Slides / Pervin Anklesaria Slides / Khadija Richards Slides / Huub Gelderblom Slides

Avac Event

What’s All the Buzz About: mRNA, manufacturing, vaccine access

Local production has emerged as an essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. This webinar will explore how might local manufacturing and the new mRNA Hub in South Africa facilitate access and support R&D.

Featuring Petro Terblanche of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group.

Recording / Caryn Fenner Slides / Mike Frick Slides / Ike James Slides

Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?

May 17, 2023

With several large HIV vaccine trials in the last few years finding no efficacy, the field is in transition. There are diverse ideas in vaccine research, but there’s no clear concept that’s ready to test in a late-phase trial or move towards product development currently. Researchers are back to testing new ideas in early phase research.

In this episode of our Px Pulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?, Dr. Katy Stephenson explores the implications of recent trial results, the big questions driving next generation vaccine development, and new strategies underway in early phase research. Katy is a doctor, a researcher, a professor of medicine at Harvard Medical School, affiliated with Beth Israel Deaconess Medical Center, and part of the Center for Virology and Vaccine Research.

Listen

Resources

HIV Vaccine Awareness Day (HVAD) 2023

In 2023, AVAC and CASPR partners cast a spotlight on many issues and opportunities for HIV vaccine science. This one-pager highlights key conversations.

Avac Event

ICASA 2023

Join AVAC and partners for the biennial International Conference on AIDS and Sexually Transmitted Infections (ICASA), in Harare, Zimbabwe December 4-9. More than 30 of our partners will convene at the meeting to champion community leadership and amplify their role in shaping local, national and global responses and delivering impactful advocacy. Community leadership on a range of issues are instrumental to: 

  • Accelerate and expand access to proven prevention options that people want and need. 
  • Dismantle the structural barriers to health faced by key populations. 
  • Intensify demands for robust domestic and global funding for health. 
  • Integrate HIV services with sexual and reproductive health. 
  • And much more. 

Scroll down for a roadmap to ICASA’s prevention program, and details on sessions and events that you won’t want to miss. 

Sessions of Interest

Sunday, December 3

  • Biomedical Prevention Forum 
    9:00-15:00 GMT 
    The Biomedical Prevention Forum will be held as a hybrid event bringing together advocates, civil society representatives, researchers, government officials and front-line providers to explore and discuss the latest advancements, challenges, and opportunities in biomedical HIV prevention, while emphasizing the importance of choice and its transformative impact on HIV prevention efforts. This is an open event. Register here. 
  • Key Populations Preconference 
    9:00-15:00 GMT 
    The Africa Key Populations Experts Group (AKPEG), African Sex Workers Alliance (ASWA), the African Network of People Using Drugs (AfricanPUD) and African Queer Youth Initiative (AQYI) Advocates for Prevention of HIV and AIDS in Africa (APHA), Global Black Gay Men Connect (GBGMC) and partners will host a safe platform to deliberate on the state of the HIV epidemic among Key Populations and to determine the stumbling blocks for progress on the path that ends AIDS for Key Populations.

Monday, December 4

Tuesday, December 5

  • Advancing Integrated Biomedical Prevention: Best Practices from Zimbabwe (Session 2) 
    8:45-09:30 GMT
    This satellite session will discuss best practices and lessons learned from the delivery of biomedical HIV prevention and Voluntary Medical Male Circumcision services as we work to further universal health coverage and robust health systems. Partners will launch a global call to action to unite, mobilize, and advocate for continued prioritized funding, sustained commitment, and strategic integration of VMMC into national and global prevention strategies.
  • Catalyzing a sustainable HIV prevention agenda: Approaches to expand local action on global commitments
    10:45-11:30 GMT
    Leveraging new strategic plans for HIV prevention, including the PEPFAR’s 5-year Strategy and UNAIDS’ Prevention Road Map, this satellite session will discuss combination prevention in the context of a sustainable HIV response and highlight a variety of approaches and models that leverage country and stakeholder-led innovations to meet the challenge.
  • Coordinating Implementation Science for CAB for PrEP: BioPIC’s Implementation Study Tracker 
    12:25-12:35 GMT
    In this oral abstract session, AVAC will present a new dashboard, which reflects all currently known activities relating to implementation research, modelling, clinical research, and landscaping for new late-stage biomedical HIV PrEP options, including cabotegravir for PrEP and the dapivirine vaginal ring.
  • Policy, Politics and HIV Management 
    13:05-13:50 GMT
    In this oral abstract session, Princess Mharire from Pangaea Zimbabwe AIDS Trust (PZAT) will present, Beyond Metrics: How the Simple Participatory Assessment of Real Change (SPARC) Tool Provides a Holistic Approach to Advocacy Measurement, and Joseph Njowa of PZAT will share the COMPASS MERL model in a presentation, Innovative tools for planning, monitoring, and evaluation of advocacy campaigns. 

Wednesday, December 7

Friday, December 8

  • Strengthen integration for better SRHR outcomes 
    10:45-11:30 GMT
    This concurrent session will feature Advocates for Prevention of HIV and AIDS in Africa’s (APHA) Yvette Raphael and will explore linkages between unintended pregnancies, unsafe abortion, and HIV.
  • HIV Prevention-Right Place, Right time 
    13:05-13:50 GMT
    This concurrent session will feature Maureen Luba of AVAC, Definate Nhamo of PZAT and Yvette Raphael of APHA. 

AVAC and Partner Poster Presentations

Tuesday, December 5 

  • Maximizing private pharmacies for PrEP delivery to increase uptake: Lessons learnt from the Community Retail Pharmacy Distribution Point, Ruth Akulu 

Wednesday, December 6 

  • Journalist Training: A Key Advocacy Strategy, Catherine Madebe
  • Perceptions on the new biomedical HIV prevention methods among adolescent girls and young women in tertiary institutions in Zimbabwe, Cleo Makura
  • Lessons from Crisis Response from TaNPUD in Enhancing Harm Reduction from 2015 to 2018, Marineus Mutongore
  • Implementing Community led Monitoring for improved quality of HIV services in Tanzania, Mathew Kawogo
  • Impact of social media exposure on HIV services uptake among Tanzanian Young people: Implications for enhancing the HIV response, Marineus Mutongore
  • Effective Strategies for Operating COWLHA support groups of Adolescents Living with HIV: Case of Mangochi and Chikwawa Districts of Malawi, Harry Madukani

Thursday, December 7 

  • Understanding Choice of HIV Prevention Options among Adolescent Girls and Young Women (AGYW) in Zambia, Natasha Mwila
  • Leveraging HIV to Build a Global Health Research and Development (R&D) Equity Advocacy Agenda, John Meade
  • Championing advocacy for domestic resource mobilization for health research and development in Africa, Ethel Makila

Friday, December 8 

  • Rural Youth: Underserved and Unsafe When Seeking Care, Liyema Somnono
  • Redefining Coalition Governance and Leadership in Support of Decolonizing Global Health: The Evolution of the COMPASS Coalition, Roberta Sutton
  • Collaborative Monitoring & Evaluation to Support Learning and Strengthen Advocacy Coalitions: The MERL Hub, Grace Tetteh
  • Realities faced by street children predisposing them to HIV and STIs in Dodoma and Dar es Salaam Cities in Tanzania, Simon Shilagwa 

A Recap of Resources: UNAIDS meeting, HVAD webinars and more

In this round up of updates and resources, you’ll find a read-out of the May UNAIDS high-level meeting in Geneva, two webinars that spotlight critical issues for vaccines R&D and the potential of broadly neutralizing antibodies, and an upcoming webinar looking at alternatives to long-acting PrEP. Read on and join us!

The HIV Response at UNAIDS High-level Meeting
A high-level meeting in Geneva, held by UNAIDS last month on the margins of the World Health Assembly, brought together advocates and experts through the Global HIV Prevention Coalition to discuss where action is needed most to bolster HIV response and advance global health equity. Read AVAC’s summary of the meeting in our latest P-Values blog.

title card with presentation info

Vaccines in 2023 and Beyond
AVAC hosted two webinars in commemoration of HIV Vaccine Awareness Day. They offer a snapshot on the state of the field for an HIV vaccine, and explore considerations for the development and delivery of vaccines against future pandemics. Check them out below and read more in our HVAD one-pager!

What’s All the Buzz About: mRNA, manufacturing, vaccines access Local production has emerged as an essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. This webinar explored how local manufacturing and the new mRNA Hub in South Africa could facilitate access and support R&D. Check out the summary and recording.

To bNAb or not to bNAb? The case for broadly neutralizing antibodies AVAC and partners explored the potential role of bNAbs in prevention, the status of research and development, and implications for HIV vaccine research. Check out the summary and recording.

Upcoming
PrEP In Black America Presents Mpox Webinar
PrEP in Black America alongside a panel of experts will discuss the impact of mpox on Black communities, advocacy and mobilization to keep our communities safe, and information on vaccine effectiveness. Tuesday, June 20 at 2:00 PM to 3:30 PM ET. Register here.

PrEP That Booty: The latest on rectal microbicide research for the back door
Most of the coverage of the HIV prevention pipeline is about long-acting, longer-acting, and even longer-acting products that deliver drug throughout the body and require a trained clinician to deliver. However, these attributes are not desirable to many folks, and communities want a range of choices. Learn more about the alternatives at this webinar. Thursday, June 29 at 9:00 AM to 10:30 AM ET. Register here.

HIV Vaccine Awareness Day (HVAD) 2023

May 18th is recognized as HIV Vaccine Awareness Day (HVAD), and this year it is a time of deep reflection and potential. Three major HIV vaccine trials have ended in no efficacy since 2020, but the field knows more than ever that a vaccine is still needed for a durable and sustainable end to the pandemic – and has new insights into possible vaccine strategies that might one day effectively protect against HIV.

This year, AVAC and CASPR partners are casting a spotlight on the many issues and opportunities for HIV vaccine science. See below for three important conversations

Podcast: Listen to AVAC’s PxPulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why, featuring Katy Stephenson of Harvard Medical School, Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research. In conversation with AVAC’s Jeanne Baron, Katy provides an accessible breakdown on the status of the field of HIV vaccine research, including details on recent trial results that proved ineffective and what’s next (and exciting) in HIV vaccine advocacy and research.

“The field needs to expand the diversity of scientists who are thinking of new ideas. We haven’t gotten far with the ideas coming out exclusively from the United States and Europe. We need to bring in young scientists of diverse backgrounds all over the world to think of ideas we can’t even imagine.”

“We now know that non-broadly neutralizing antibodies don’t work, but broadly neutralizing antibodies can work. It’s a big milestone in the field to have that kind of knowledge now.”

Katy Stephenson, Harvard Medical School and Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research

Webinars: AVAC brought together partners, advocates and other experts for two vaccine webinars. The first, on local manufacturing production, takes on this essential part of the solution for ensuring sustainable and equitable supplies of vaccines in low- and middle-income countries. The second explores the development of broadly neutralizing antibodies (bNABs) and their potential in HIV prevention. Check out the recording and slides for both.

What’s All the Buzz About: mRNA, manufacturing, vaccines access – featuring Caryn Fenner of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group. 

“LMICs (Low- or Middle-Income Country) are not only the consumers of IP (Intellectual Property), we are the generators of IP!” Caryn Fenner, Afrigen Biologics

“It’s important for us in the Global North to know that vaccine technology didn’t start in Global North and was often taken from others.” Mike Frick, Treatment Action Group.

“Engagement and commitment [is needed], not only when a pandemic exists, but long-term commitments are key to follow through on.” Ike James, Medicine Patents Pool

To bNAb or not to bNAb? The case for broadly neutralizing antibodies – featuring Slim Abdool Karim of CAPRISA, Pervin Anklesaria of Bill & Melinda Gates Foundation, Khadija Richards of Wits RHI, and Huub Gelderblom of HIV Vaccine Trials Network (HVTN).

“The scientific complexities of bNAbs require a more attuned focus on community engagement… And it will require a high degree of validating [people’s] lived experience.”, Khadija Richards, Wits RHI.

“The hope is that if bNAbs are effective in prevention, they create a pathway towards a vaccine.” Slim Abdool Karim, CAPRISA

“To close the gap between scientific innovation and globally accessible and affordable bNAb combination products…we certainly need innovation in manufacturing. It is a long-term process and it’s not going to happen overnight. But we do need to start now.” Pervin Anklesaria, Bill & Melinda Gates Foundation

“What I see is actually multiple modes of PrEP available, and then people can make choices depending on what works for them.” Huub Gelderblom of the HIV Vaccine Trials Network on the potential of bNAbs as PrEP

What’s All the Buzz About: mRNA, manufacturing, vaccine access

Exploring the potential role of bNAbs in prevention

AVAC and partners hosted a conversation to explore the potential role of bNAbs in prevention, current status in the field, and key issues to consider in HIV vaccine research.

Panelists included: Slim Karim, CAPRISA, Pervin Anklesaria, Bill & Melinda Gates Foundation, Khadija Richards, Wits RHI, Huub Gelderblom, HIV Vaccine Trials Network (HVTN)
Hosted By: Mitchell Warren, AVAC and Stacey Hannah, AVAC

Recording / Slim Karim Slides / Pervin Anklesaria Slides / Khadija Richards Slides / Huub Gelderblom Slides

HIV Vaccine Awareness Day 2023: Hard lessons, innovation & new directions

May 18th is recognized as HIV Vaccine Awareness Day (HVAD), and this year it is a time of deep reflection and potential. Three major HIV vaccine trials have ended in no efficacy since 2020, but the field knows more than ever that a vaccine is still needed for a durable and sustainable end to the pandemic – and has new insights into possible vaccine strategies that might one day effectively protect against HIV.

This year, AVAC and CASPR partners are casting a spotlight on the many issues and opportunities for HVAD 2023. Check it all out here! And read on for details about a wide range of new resources.

New PxPulse Podcast Episode!

billboard advertising the new podcast episode

Listen to the newest PxPulse podcast, “Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why,” featuring Katy Stephenson of Harvard Medical School, Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research. In conversation with AVAC’s Jeanne Baron, Katy provides an accessible breakdown of where the field of HIV vaccine research is, including details on recent trial results that proved ineffective and what’s next (and exciting) in HIV vaccine advocacy and research.

Save the Date for Two Upcoming Webinars!

save the date advertisement for these upcoming webinars

What’s All the Buzz About: mRNA, manufacturing, vaccines access

Thursday, June 1 at 10am ET / 4pm SAST
Featuring Caryn Fenner of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group. Register here.

To bNAb or not to bNAb? The case for broadly neutralizing antibodies

Wednesday, June 7 at 10 AM ET / 4 PM SAST
Featuring Slim Abdool Karim of CAPRISA, Pervin Anklesaria of Bill & Melinda Gates Foundation, Khadija Richards of Wits RHI, and Huub Gelderblom of HIV Vaccine Trials Network (HVTN). Register here.

CASPR Partner and Collaborator HVAD Events

Communities across the globe will be engaged in a wide array of events focused on HIV vaccine awareness in the coming days. Here, we provide details on activities the Coalition to Accelerate & Support Prevention Research (CASPR) partners are leading – be sure to watch AVAC’s Twitter for real-time highlights!

New Series of Advocate Briefs

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In the weeks to come, we’ll release From the Lab to the Jab, a series of briefs on next generation vaccine research and development; the basics of mRNA technology; initiatives that support local manufacturing; and understanding and overcoming barriers that undermine equitable access to vaccines. Each brief also highlights the advocacy needed to keep these efforts on track and in line with what communities need and want.

New Resources

AVAC has updated our recent HIV vaccine primers. And we’re sharing a viewpoint written in the Journal of the International AIDS Society.

As the science continues to advance, we hope these resources inform our collective advocacy. With the knowledgeable voices of advocates guiding the response, scientific successes will not be squandered, communities won’t be left behind, programs will be people-centered, and epidemics will end.