Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue identifies ten key outcomes to pursue in order to make progress in beginning to end the AIDS epidemic. This issue also covers Gilead Science’s submission to the FDA for a label change for TDF/FTC (brand name Truvada); the closure of the 1% tenofovir gel arm of the VOICE trial; new trials launched this quarter; the first meeting of Project ARM (Africa for Rectal Microbicides).
Px Wire January-March 2012, Vol. 5, No. 1
Px Wire October-December 2011, Vol. 4, No. 4
Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue includes updates on what will come next for the AIDS vaccine regimen that showed modest efficacy in the trial known as RV144; the recent VOICE trial modification; progress in demonstration projects, public health guidance and regulatory decision-making around PrEP in the United States; and, a table of early-phase studies of ARV-based prevention strategies for HIV-negative people.
Px Wire October-December 2010, Vol. 3, No. 4
Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. Highlights in this issue include an update of the ongoing discussions around the follow-up of the CAPRISA 004 trial finding that 1% tenofovir gel reduces a women’s risk of acquiring HIV by 39 percent overall and asks follow-up questions. What additional trials are being considered and why? Who will map the next steps? This issue also touches on the increasing discussions of “treatment as prevention” in reference to the possible use of antiretroviral treatment to reduce the risk of HIV transmission.
We can use it if it’s made for us: Kenyan Sex workers perspectives and Voices on Microbicides and PrEP
This report gathers perceptions and concerns from female sex works in Kenya concerning access to microbicides and PrEP. It highlights the importance of engaging this key population in product research and development.
Px Wire April-June 2009, Vol. 2, No. 2
Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue features multiple trial updates, including a review of the key findings from a trial of HSV-2 suppression. The issue also features a discussion of the results of the HPTN 035 microbicide trial (which tested PRO 2000 and BufferGel) and preparations for the upcoming results of MDP 301, also testing PRO 2000 gel. Additionally, this issue provides information on new trials including HVTN 505 (described in this year’s first issue of Px Wire), which began screening participants in June, a new trial on intermittent PrEP scheduled to begin in July, and research to test a nipple shield to help prevent HIV transmission during breastfeeding.
FDA’s Advisory Committee Review of Daily Oral Truvada as PrEP to Reduce the Risk of HIV Infection: An advocate’s primer for public participation
This primer was developed to help advocates understand the mechanism of the US Food and Drug Administration’s external advisory committee. It was specifically developed in preparation for the US FDA review of Truvada for use as PrEP in 2012. It offers a guide to the workings of the external advisory committee (a set of outside experts who make recommendations) and ways for civil society to participate in the process.
Anticipo de los Resultados de Ensayos de PrEP: Una poderosa herramienta nueva para la prevención del VIH podría estar cerca. ¿Estamos preparados para ella?
A 2008 document providing background information on pre-exposure prophylaxis (PrEP) and discussing efficacy trials that were then planned and ongoing. It discusses the research agenda and key advocacy priorities to move PrEP research forward.
Trials of Intermittent Dosing of Pre-Exposure Prophylaxis (PrEP): Summary from an AVAC think tank
Four-page summary of 2008 meeting on possibilities for intermittent PrEP research.
Anticipating the Results of PrEP Trials: A powerful new HIV prevention tool may be on the horizon. Are we prepared?
A 2008 document providing background information on pre-exposure prophylaxis (PrEP) and discussing efficacy trials that were then planned and ongoing. It discusses the research agenda and key advocacy priorities to move PrEP research forward.
PrEP Financing in the US: Summary from an AVAC think tank
A six-page summary of an AVAC-convened think tank exploring possibilities of financing for PrEP in the United States.