New Resources to Help Navigate the News on HIV and COVID-19

The latest news on R&D breakthroughs for prevention of COVID-19 and HIV brings to our lips this call: it’s time to be ready for action with dogged determination to demand transparency, accountability, evidence and equity. In case you missed it, AVAC has new resources to help prepare.

Long-Acting PrEP and the HIV Prevention Pipeline

HPTN 084 Primary Study Results Webinar – Download the HPTN webinar with trial leaders from HPTN 084 who discuss the primary results of HPTN 084.

Landmark Trial in East and Southern Africa Finds Injectable PrEP Safe and Effective for Cisgender Women – Read AVAC’s statement on HPTN 084’s efficacy findings and what must come next.

The Future of ARV-Based Prevention and Biomedical HIV Prevention Trials: Results, milestones and more – Check out the updates to our infographics on the HIV prevention pipeline.

HIV-Specific Neutralizing Antibodies by Target and Broadly Neutralizing Antibody Combinations – We’ve also updated these infographics on broadly neutralizing antibodies in HIV prevention research.

AMP-ticipation: Context and concepts for understanding the AMP Trials – Read this blog to prepare for the forthcoming results from the Antibody Mediated Prevention Study.

Protecting Global Gains

Protectingglobalgains.org – At this recently launched site, Amref Health Africa, AVAC and Friends of the Global Fight have come together to document the impact COVID-19 is having on global health programs and the innovative solutions that are being developed and implemented all over the world.

Global PrEP Tracker – This update of Q3 data shows overall global uptake continued to climb even in the midst of COVID-19. The number of people who have started on PrEP has reached 773,474, an increase of more than 23 percent since the year began.

The Promise and Challenge of PrEP for Adolescent Girls and Young Women – Listen to this podcast from our colleagues at CSIS, which includes perspectives from AVAC and Wits RHI.

Efficacy & Equity: Twin Powers to End Epidemics

Why exciting results from vaccine research are just the beginning of efforts to end COVID-19 – AVAC’s Mitchell Warren penned this Devex op-ed, pointing to important lessons from the field HIV on the steep but scalable challenges of turning highly effective prevention tools into real and accessible options for people in need.

Advocate’s Guide to COVID-19 Vaccine Access – A plain-language guide covering the necessary components for equitable COVID-19 vaccine access to help inform and support advocates.

Treatment Action Group and AVAC Statement on Pfizer/BioNTech COVID-19 Vaccine Efficacy Announcement – Read our statement with the Treatment Action Group (TAG) to learn more about what must come next to move forward with COVID-19 vaccines.

Efficacy News from Second COVID-19 Vaccine Trial Underscores Need for Transparency and Cooperation between Outgoing and Incoming US Administrations – Read this statement joint statement from AVAC and TAG to learn how and why US leaders must put people ahead of politics.

At AVAC, we’re watching for more COVID-19 vaccines that may soon join the two now showing efficacy, while our eyes remain firmly on HIV prevention options still in the pipeline. At the same time, no less focus is needed on programs and policies for equitable access. Use these resources to work with health leaders of all stripes to build the systems the world needs for prevention to become a reality everywhere it’s needed.

Biomedical HIV Prevention Trials: Results, milestones and more

This graphic shows the updated status of large-scale prevention trials through 2022 and the impact of COVID-19 on each trial.

Another version of this graphic is available here (same content, different visual Treatment U=U).

Regulatory Approval Primer for Vaccine Advocates

The difference between speed and cutting corners can be one of life or death for individuals, and of impact versus impasse for societies. Advancing a vaccine candidate without peer-reviewed research results and thorough regulatory review can also undermine confidence in public institutions and vaccines generally. Global health advocates have an essential role to play as watchdogs of the regulatory systems that have worked well for decades, but may be vulnerable to global pressure for a vaccine and the current politicization of science.

COVID-19 Vaccine Pipeline PowerPoint Presentation

This set of slides offers advocates a view of the funders, platforms, research phase and considerations for some of the front-runner candidates.

Advocates’ Guide: The risks and benefits of expedited COVID-19 vaccine research

This guide highlights the strategies being implemented to shorten the COVID-19 vaccine development timeline and the benefits, risks and key takeaways for each.

Research Fundamentals: What is partial protection?

AVAC is launching a new series on our podcast Px Pulse—Research Fundamentals. In addition to our regular schedule of programs covering advances and challenges in HIV prevention research, Research Fundamentals we’ll explore scientific concepts in research, one at a time.

In our debut episode we explore the concept of partial protection, with:

  • David Evans, science and advocacy consultant for AVAC, formerly of Project Inform
  • Penny Moore from South Africa’s University of the Witwatersrand and National Institute for Communicable Diseases
  • And Sandhya Vasan of the US Military HIV Research Program

Together we explore the meaning of partial protection. Whether it’s condoms, a flu shot, oral PrEP or the dapivirine vaginal ring, proven products fall short of 100 percent protection against disease, and there’s a lot to know about how and why an intervention may offer imperfect but still useful protection.

Listen

To Accelerate Search for COVID-19 Vaccine, Look to HIV and Act Globally

This post first appeared on Devex.

In just six months, the virus that causes COVID-19 has spread around the world, infected over 5 million people, and exacted devastating public health and economic tolls that are only just beginning. Unprecedented efforts to accelerate the development of a vaccine for the virus underscore the urgency of this public health crisis.

We have the benefit of history to provide a clear vision of what must happen with COVID-19. We stand on the shoulders of giants in the fight against HIV who never took “no” for an answer: advocates who demanded a vaccine because they knew their lives depended on it. At the same time, they acted as if a vaccine would never arrive, thereby accelerating the development and delivery of safe and effective treatment and prevention options that have had a dramatic impact on the HIV epidemic.

Since the coronavirus crisis began, we’ve seen Gregg Gonsalves and other advocates who honed their craft advocating for HIV solutions reemerge and lead the charge. And earlier this month, the New York-based organization PrEP4All, which was founded to increase access to HIV medication, issued a report calling for research and development for coronavirus prevention options.

As we know so well from over 40 years of experience in the HIV response, developing and delivering prevention and treatment options at scale is essential to containing an epidemic. But no durable and sustainable end to any epidemic is possible without a vaccine.

Today — just months into this pandemic — there are already over 100 COVID-19 vaccine candidates in the product development pipeline. While the scientific reality is that the majority of these candidates will fail in the early stages, the sheer volume of products is evidence of the global commitment to combating this virus.

This is also another example of where we are drawing on the decades of research and hard-won progress in the field of HIV/AIDS. A recently launched report explored HIV vaccine platforms that are helping accelerate the drive for coronavirus vaccine development and are key priorities for an effective response to this pandemic. Many of the platforms, research partnerships and clinical trial capacities used in COVID-19 vaccine research were developed as part of the effort to find a preventive HIV vaccine.

To winnow down the coronavirus vaccine pipeline to probable winners, global collaboration, harmonized efficacy trials and data-sharing are key. We are already seeing tremendous political leadership, such as the Coronavirus Global Response, the recent European fundraising effort that received more than $8 billion in pledges. This also includes the Joint United Nations Programme on HIV/AIDS’ call for a “people’s vaccine,” with more than 140 world leaders and experts demanding that vaccines, treatments and tests be “patent-free, mass produced, distributed fairly and made available to all people, in all countries, free of charge.”

The US has a history of leadership in vaccine development and a particularly important role to play in the global response. The Dale and Betty Bumpers Vaccine Research Center, or VRC — originally established at the National Institutes of Health in 1997 by then-President Bill Clinton to accelerate the development of an HIV vaccine — is taking a leading role in developing promising COVID-19 vaccine candidates and getting them into clinical trials. In May, NIH leaders, including VRC and the HIV Vaccine Trials Network, published a strategic approach to coronavirus vaccine R&D.

Then came the announcement of Operation Warp Speed by the administration of President Donald Trump, with the wildly ambitious goal to deliver the 300 million doses of a vaccine by January 2021. While the specific details for the plan have yet to be released, it is being positioned as a unilateral effort, ignoring possible vaccine candidates from China and reserving the end product for Americans. This is a mistake; global health, not nationalism, must drive vaccine development and the overall COVID-19 response.

Whether there is a vaccine in time for the new year, or in 18 months, or ever, collaboration across countries, disciplines and disease areas will be crucial to the success of this effort. It is also critical that coronavirus R&D reflects the realities of people’s lives and that products and strategies developed to combat COVID-19 are informed by and will be accepted and used by the communities at greatest risk — the elderly, health care workers and those with underlying conditions.

To ensure that product development success becomes public health victory, massive public, private and philanthropic investment globally is needed to accelerate the science; communities must be engaged to both accelerate research and ensure eventual uptake; and equitable access must be the highest priority.

While some groups appear harder-hit by COVID-19, everyone on the planet will potentially need this vaccine. Policymakers, private industry, donors, regulators, the World Health Organization, Gavi and others must work to ensure rapid access to all who need new interventions. In April 1955, when journalist Edward R. Murrow asked researcher Jonas Salk who owned the patent for the polio vaccine, Salk said: “Well, the people, I would say. There is no patent. Could you patent the sun?”

A Global Pandemic Requires an Unprecedented Response

Meeting the ambitious timelines for a COVID-19 vaccine will require an unprecedented multi-faceted, coordinated global response including governments, industry, academic researchers, delivery partners, donors and civil society. This graphic represents the pillars of this landscape — with those organizations mentioned by name representing just a small fraction of the growing number of contributors in the global response to the COVID-19 pandemic.

Excerpted from Five “P”s to Watch.

The Race for a Coronavirus Vaccine

Will compressed and overlapping steps get a vaccine faster?

This graphic compares a conventional timeline for vaccine development, anticipating a COVID-19 vaccine available by May 2036, versus the accelerated goal of developing, producing and distributing a vaccine much, much faster. Excerpted from Five “P”s to Watch.

COVID-19 Vaccine Pipeline Snapshot

A snapshot of the COVID-19 vaccine pipeline. Excerpted from Five “P”s to Watch.