What’s All the Buzz About: mRNA, manufacturing, vaccine access

Exploring the potential role of bNAbs in prevention

AVAC and partners hosted a conversation to explore the potential role of bNAbs in prevention, current status in the field, and key issues to consider in HIV vaccine research.

Panelists included: Slim Karim, CAPRISA, Pervin Anklesaria, Bill & Melinda Gates Foundation, Khadija Richards, Wits RHI, Huub Gelderblom, HIV Vaccine Trials Network (HVTN)
Hosted By: Mitchell Warren, AVAC and Stacey Hannah, AVAC

Recording / Slim Karim Slides / Pervin Anklesaria Slides / Khadija Richards Slides / Huub Gelderblom Slides

Avac Event

Tales from Two Cities: HIV and STI research highlights from Brisbane and Chicago

August 3, 2023 at 9am ET

(Time Converter)

TCA’s invited experts will share their highlights and reflections on the HIV and STI-related science presented at two major global health conferences. These conferences include IAS 2023, taking place in Brisbane, Australia July 23 – 26 and the 2023 STI and HIV World Congress happening in Chicago (United States) from July 24 – July 27.

Speakers include:
Dr. Aniruddha Hazra – University of Chicago
Nyaradzo M Mgodi – University of Zimbabwe
Roger Pebody – NAM, Aidsmap.com
Charlie Peterson – University of Illinois – Chicago

AVAC Statement on Uganda’s Anti-Gay Law and Other Resources

As we prepared this collection of highlights and resources on a wide range of issues, we learned that Uganda’s President Museveni had signed into law the Anti-Homosexuality Act of 2023. You’ll find our statement condemning Uganda’s enactment of the hate-filled and dangerous new law at the top our newsletter, and we hope you’ll follow the links in this statement to our partners who are working in solidarity to defeat it. Around the world, the voices of advocates have never been more important, and our joint action to oppose hate and discrimination is imperative now, to sustain the gains that have been made against HIV, to save lives, and to fulfill the promise of equity in global health.

Scroll down for other resources and updates that are shaping global health and the HIV response. These include: new data and infographics in PxWire; perspectives from the World Health Assembly; upcoming webinars on vaccine manufacturing and broadly neutralizing antibodies; new publications on multipurpose prevention technologies (MPTs); highlights from the PrEP in Black America Summit; new STI resources; and a recent webinar on expanding HIV cure research across Africa!

AVAC Condemns Uganda’s Anti-Homosexuality Bill 2023
AVAC’s statement denounces the decision by Uganda President Yoweri Museveni to sign the legislation into law and calls for solidarity with Uganda’s LGBTQIA+ and civil rights advocates who are demanding the courts uphold Uganda’s constitution and prevent this law from going forward.

The Latest Px Wire
Our quarterly snapshot of biomedical HIV prevention R&D, implementation and advocacy features updates and infographics on oral PrEP uptake, implementation science studies with injectable cabotegravir for PrEP and the dapivirine vaginal ring, and incidence rates from HIV prevention trials over the past 25 years.

The World Health Assembly and PPPR
As the World Health Assembly made news last week by approving a 20 percent increase to the WHO budget, advocates are calling the early draft of the pandemic accord a step backward for equity. Several moving pieces are setting up a new architecture for global health. Learn how all this work on pandemic prevention, preparedness and response (PPPR) fits together, and where advocates can engage in AVAC’s Advocates Guide for PPPR in 2023. For further background, read our position paper on PPPR and find links to related webinars and podcasts here.

For perspective on increased funding to the WHO and the evolving new architecture for global health, listen to A Shot In The Arm podcast episode, “Too Fund or Not Too Fund The WHO. That is the question”, featuring a conversation with AVAC Executive Director, Mitchell Warren, Global Health Council Executive Director Elisha Dunn-Georgiou and podcast host Ben Plumley.

And, UNAIDS and the Global HIV Prevention Coalition hosted a special session, A High-Level Dialogue on Accelerating HIV Prevention and Future Pandemics. Check it out to hear civil society representatives, ministers of health, and leaders of UNAIDS, The Global Fund, PEPFAR and AVAC talk about the opportunities and challenges in delivering on the promise of current HIV prevention options.

SAVE THE DATE: Two Upcoming Vaccine Webinars
On May 18th, AVAC and the Coalition to Accelerate & Support Prevention Research (CASPR) marked HIV Vaccine Awareness Day (HVAD) with a package of resources, and highlights of activities. Our HVAD program continues with two upcoming webinars exploring the changing landscape of vaccine research, development and advocacy.

What’s All the Buzz About: mRNA, manufacturing, vaccines access
Thursday, June 1 at 10am ET / 4pm SAST. Register here.

To bNAb or not to bNAb? The case for broadly neutralizing antibodies
Wednesday, June 7 at 10 AM ET / 4 PM SAST. Register here.

Paving The Way for The Dual Prevention Pill
Frontiers in Reproductive Health published a special issue on MPTs! AVAC’s Kate Segal is a co-author of Equipping providers to offer novel MPTs: Developing counseling messages for the Dual Prevention Pill in clinical studies and beyond, and partners from CHAI and the DPP Consortium contributed the article Cost-effectiveness of the dual prevention pill for contraception and HIV pre-exposure prophylaxis.

PrEP in Black America
The 2023 summit on PrEP in Black America ended May 19 on a high note with a crucial policy conversation with the Director of the White House Office of National AIDS Policy, Harold Philips, on a proposal to advance a national PrEP program in the US. Interested to learn more? Check out the 2023 report from PrEP in Black America, For Us, By Us: PrEP In Black America: A Master Plan For HIV Prevention In Black America.

STI Advocacy
AVAC has been expanding our advocacy for STI prevention, from better diagnostics to vaccine development. The recent conference of the National Coalition of STD Directors (NCSD) featured key discussions on resource allocation and on DoxyPEP, with guidelines expected from the CDC before the end of year. See our new STI factsheet, watch the TCA October 2022 webinar on Doxy for STIs, and bookmark STI Watch.org for further background.

Pioneering HIV Cure Research Where It’s Needed Most
AVAC and a number of partners hosted Advancing HIV Cure to Africa: What is needed? The webinar features two panel discussions on how researchers, communities and other stakeholders from high income countries can work equitably with low- and middle-income countries in the interests of an HIV cure for all. Find the recording and learn more here.

HIV Vaccine Awareness Day 2023: Hard lessons, innovation & new directions

May 18th is recognized as HIV Vaccine Awareness Day (HVAD), and this year it is a time of deep reflection and potential. Three major HIV vaccine trials have ended in no efficacy since 2020, but the field knows more than ever that a vaccine is still needed for a durable and sustainable end to the pandemic – and has new insights into possible vaccine strategies that might one day effectively protect against HIV.

This year, AVAC and CASPR partners are casting a spotlight on the many issues and opportunities for HVAD 2023. Check it all out here! And read on for details about a wide range of new resources.

New PxPulse Podcast Episode!

billboard advertising the new podcast episode

Listen to the newest PxPulse podcast, “Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why,” featuring Katy Stephenson of Harvard Medical School, Beth Israel Deaconess Medical Center, and the Center for Virology and Vaccine Research. In conversation with AVAC’s Jeanne Baron, Katy provides an accessible breakdown of where the field of HIV vaccine research is, including details on recent trial results that proved ineffective and what’s next (and exciting) in HIV vaccine advocacy and research.

Save the Date for Two Upcoming Webinars!

save the date advertisement for these upcoming webinars

What’s All the Buzz About: mRNA, manufacturing, vaccines access

Thursday, June 1 at 10am ET / 4pm SAST
Featuring Caryn Fenner of Afrigen Biologics, Ike James of Medicines Patent Pool, and Mike Frick of Treatment Action Group. Register here.

To bNAb or not to bNAb? The case for broadly neutralizing antibodies

Wednesday, June 7 at 10 AM ET / 4 PM SAST
Featuring Slim Abdool Karim of CAPRISA, Pervin Anklesaria of Bill & Melinda Gates Foundation, Khadija Richards of Wits RHI, and Huub Gelderblom of HIV Vaccine Trials Network (HVTN). Register here.

CASPR Partner and Collaborator HVAD Events

Communities across the globe will be engaged in a wide array of events focused on HIV vaccine awareness in the coming days. Here, we provide details on activities the Coalition to Accelerate & Support Prevention Research (CASPR) partners are leading – be sure to watch AVAC’s Twitter for real-time highlights!

New Series of Advocate Briefs

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In the weeks to come, we’ll release From the Lab to the Jab, a series of briefs on next generation vaccine research and development; the basics of mRNA technology; initiatives that support local manufacturing; and understanding and overcoming barriers that undermine equitable access to vaccines. Each brief also highlights the advocacy needed to keep these efforts on track and in line with what communities need and want.

New Resources

AVAC has updated our recent HIV vaccine primers. And we’re sharing a viewpoint written in the Journal of the International AIDS Society.

As the science continues to advance, we hope these resources inform our collective advocacy. With the knowledgeable voices of advocates guiding the response, scientific successes will not be squandered, communities won’t be left behind, programs will be people-centered, and epidemics will end.

Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?

Produced and hosted by Jeanne Baron

With several large HIV vaccine trials in the last few years finding no efficacy, the field is in transition. There are diverse ideas in vaccine research, but there’s no clear concept that’s ready to test in a late-phase trial or move towards product development currently. Researchers are back to testing new ideas in early phase research.

In this episode of our Px Pulse podcast, Evolving Strategies for an HIV Vaccine: One researcher explains where the field is going and why?, Dr. Katy Stephenson explores the implications of recent trial results, the big questions driving next generation vaccine development, and new strategies underway in early phase research. Katy is a doctor, a researcher, a professor of medicine at Harvard Medical School, affiliated with Beth Israel Deaconess Medical Center, and part of the Center for Virology and Vaccine Research.

Listen:

Resources:

Experimental Medicine Vaccine Trials (EMVTs): Opportunities and Challenges

In 2023, AVAC and CASPR partners cast a spotlight on many issues and opportunities for HIV vaccine science. This one-pager highlights key conversations.

Avac Event

SCOPE Community E-meeting: Developments in the HIV and STIs biomedical prevention pipeline

The European AIDS Treatment Group, along with European and local organizations are coming together for a virtual meeting via Zoom e-meeting on Wednesday, May 24 at 6:00 to 7:30 AM ET (12:00 – 13:30 PM CET).

This interactive e-meeting for community educators and advocates will provide an update on the latest developments in biomedical HIV and STIs prevention research and implementation, new approaches and future challenges. Participants will learn from each other and discuss community preferences, uptake and access issues, as well as advocacy efforts to overcome policy and financial barriers at local, regional and European level. Live interpretation in English and Russian will be provided. This meeting is part of the SCOPE Project.

Avac Event

SCOPE Community E-meeting: Developments in PrEP implementation issues

The European AIDS Treatment Group, along with European and local organizations are coming together for a virtual meeting via Zoom e-meeting on Wednesday, May 24 at 6:00 to 7:30 AM ET (12:00 – 13:30 PM CET).

This interactive e-meeting for community educators and advocates will provide an update on the latest developments and issues in PrEP implementation. Participants will learn from each other and discuss community preferences, uptake and access issues, as well as advocacy efforts to overcome policy and financial barriers at local, regional and European level. Live interpretation in English and Russian will be provided. This meeting is part of the SCOPE Project.

Avac Event

Women Deliver 2023

The Women Deliver 2023 Conference (WD2023) will take place in  Kigali, Rwanda  and online from July 17 to July 20.

Women Deliver convenings catalyze conversations with stakeholders from around the world, break barriers, address challenges, and identify opportunities to advance gender equality and sexual and reproductive health and rights (SRHR), and improve the wellbeing of girls and women, in all their intersecting identities.

Avac Event

IAS (International AIDS Society) 2023

The 12th annual conference of the International AIDS Society (IAS) on HIV science takes place July 23–26 in Brisbane, Australia, and virtually. This year’s conference will offer the latest on vaccine and cure science, research updates on broadly neutralizing antibodies, important discussions on trial design in the era of PrEP, the potential of community-led models of care and the importance of integrating services for HIV and sexual and reproductive health (SRH). AVAC and partners will be there! Read on for an overview.

Just ahead of the conference, UNAIDS released their annual state of the epidemic report, The Path that Ends AIDS. The report charts a path that can end AIDS, and documents important progress, but challenges remain. Among them, global resources for HIV are marking another year of decline. With anti-LGTBQIA+ legal actions increasing in the US and in several African countries and reduced resources, efforts to end the epidemic will fail. See AVAC’s new graphic on the issue.

IAS Resources

  • Use AVAC’s Roadmap to find sessions where prevention, pandemic preparedness and the larger issues of global health equity are in the spotlight. You can download it as a sortable spreadsheet or PDF.
  • Follow events in real time, AVAC will offer comments and updates on Twitter, and our friends at NAM/AIDSMAP will be reporting throughout the conference. Join the conversation using the conference hashtag #IAS2023.

Satellites, Sessions and Panels Featuring AVAC and Partners

All times listed are local in Brisbane, Australia. Click for a time zone converter.

Sunday, July 23

Tuesday, July 25

Wednesday, July 26

Poster Presentations

  • No Data No More: A tool to end the exclusion of trans and gender-diverse people in HIV research
  • Raising New Voices in HIV Cure Research: A review of an advocacy-for-cure academy and grant program
  • The Value of Measuring Outcomes of HIV Advocacy: Utilising a novel and participatory approach for advocacy evaluation
  • HIV Prevention Research & Development Investments 2001-2021: Shifting investment priorities fund innovation in a challenging global health landscape
  • Revolution of Transgender Health Programming: The role of transgender activists in Health programming for Malawi

While many will be gathering in Australia for the IAS conference, the 27th International Society for Sexually Transmitted Diseases Research (ISSTDR)is happening in Chicago at the same time – and AVAC will be there, too. Stay tuned for an update later this week for AVAC’s STI Roadmap and dedicated STI conference page. Advocates, implementers and researchers in both fields have much work to do together.