Global Investment in HIV Cure Research and Development in 2019

In 2014, the HIV Vaccines and Microbicides Resource Tracking Working Group and AVAC began a

Regulatory Approval Primer for Vaccine Advocates

The difference between speed and cutting corners can be one of life or death for individuals, and of impact versus impasse for societies. Advancing a vaccine candidate without peer-reviewed research results and thorough regulatory review can also undermine confidence in public institutions and vaccines generally. Global health advocates have an essential role to play as watchdogs of the regulatory systems that have worked well for decades, but may be vulnerable to global pressure for a vaccine and the current politicization of science.

COVID-19 Vaccine Pipeline PowerPoint Presentation

This set of slides offers advocates a view of the funders, platforms, research phase and considerations for some of the front-runner candidates.

Cheat Sheet: COVID-19 Vaccine Pipeline

This three-pager offers advocates an at-a-glance view of the funders, platforms, research phase and considerations for some of the front-runner candidates.

Research Fundamentals: What is partial protection?

AVAC is launching a new series on our podcast Px Pulse—Research Fundamentals. In addition to our regular schedule of programs covering advances and challenges in HIV prevention research, Research Fundamentals we’ll explore scientific concepts in research, one at a time.

In our debut episode we explore the concept of partial protection, with:

  • David Evans, science and advocacy consultant for AVAC, formerly of Project Inform
  • Penny Moore from South Africa’s University of the Witwatersrand and National Institute for Communicable Diseases
  • And Sandhya Vasan of the US Military HIV Research Program

Together we explore the meaning of partial protection. Whether it’s condoms, a flu shot, oral PrEP or the dapivirine vaginal ring, proven products fall short of 100 percent protection against disease, and there’s a lot to know about how and why an intervention may offer imperfect but still useful protection.

Listen

Integration of HIV prevention and SRH services in Zimbabwe

Findings from an assessment of HIV prevention and SRH integration in Zimbabwe, conducted in collaboration with the Ministry of Health and Child Care, comprised of site visits to health facilities, key informant interviews, civil society dialogues and a policy review.

Advocates’ Primer on Injectable Cabotegravir for PrEP: Trials, Approvals, Rollout and More

Results from two large-scale efficacy trials found that injectable cabotegravir (CAB-LA), given every two months, was effective as a form of pre-exposure prophylaxis (PrEP) in preventing HIV in gay men and other men who have sex with men, transgender women who have sex with men, and cisgender women. CAB-LA was developed by ViiV Healthcare and is currently used in HIV treatment. It was approved by the US Food and Drug Administration (FDA) as the first form of injectable PrEP in December 2021. This document focuses on CAB-LA for prevention, outlining what’s known and what’s next for this emerging biomedical HIV prevention strategy.

A Collaborative Approach to HIV Prevention Product Introduction

The HIV prevention product pipeline offers exciting potential to curb HIV incidence. But we know from previous products that translating trial efficacy to population impact is challenging without coordinated effort.

The Race for a Coronavirus Vaccine

Will compressed and overlapping steps get a vaccine faster?

This graphic compares a conventional timeline for vaccine development, anticipating a COVID-19 vaccine available by May 2036, versus the accelerated goal of developing, producing and distributing a vaccine much, much faster. Excerpted from Five “P”s to Watch.

Five “P”s to Watch

HIV vaccine research is making the search for a COVID-19 vaccine faster, safer and more inclusive. The global COVID-19 response evolves by the day—seemingly, even, by the minute—as the world has watched the tally of experimental diagnostics, therapeutics and vaccines tick up into the hundreds. If researchers achieve their goal of making the search for a COVID-19 vaccine the fastest vaccine development effort in history, much of that success will be due to the research knowledge, vaccine platforms, trial networks and community engagement models created through HIV vaccine research.