Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue reviews the recent AVAC Advocacy Partners’ Forum, where partners from across sub-Saharan Africa and beyond met and discussed goals for the year ahead. This issue also covers some key content and messages from the PEPFAR Blueprint.
Px Wire January-March 2013, Vol. 6, No. 1
Px Wire October-December 2012, Vol. 5, No. 4
Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. This issue of Px Wire features an advocates’ guide to the “sieve analysis” from the RV144 vaccine trial. This latest follow-up investigation provided further detail about the partial protection associated with the vaccine strategy. This issue also updates readers with the latest on trials of ARV-containing vaginal rings—the next frontier in microbicide development.
Px Wire July-September 2012, Vol. 5, No. 3
Px Wire is AVAC’s quarterly update covering the latest in the field of biomedical HIV prevention research, implementation and advocacy. As this issue of Px Wire went to press, the US Food and Drug Administration (FDA) announced its approval of daily oral TDF/FTC for PrEP. The issue reviews global PrEP developments and presents an infographic summarizing progress towards beginning to end the AIDS epidemic. In addition, this issue includes a list of prevention research-related sessions at AIDS 2012.
Advocate’s Guide to Statistical Terms
Simple one-page resource explaining terms like “statistical significance,” “p-value,” “confidence interval” and other concepts used to describe and interpret the results of clinical trials.
What is Treatment as Prevention and What is it Not?
Simple, one-page factsheet developed in 2012 that defines treatment as prevention and what it can achieve.
Data Safety Monitoring Boards (DSMBs)
Clinical trials are monitored and regulated by a variety of entities, including independent bodies that review the trial protocol and data on an ongoing basis to ensure that the trial is ethical and should continue. This fact sheet is for advocates who would like to learn more about how these entities work, what they do, and what impact their recommendations can have on clinical trials.
Treatment as Prevention: Frequently asked questions
This FAQ was developed with input from the National Empowerment Network of People Living with HIV (NEPHAK) and Health GAP on the basis of national PLHIV dialogues on treatment as prevention conducted throughout Kenya. The questions and answers contain information relevant for a global audience—but have been written specifically for individuals living and working in low and middle income countries
Pharmacokinetics and Pharmacodynamics: A primer for HIV prevention advocates
Pharmacokinetics (PK) is the study of what happens to a drug when it is taken into the body; pharmacodynamics (PD) is the study of what happens to the body when a drug is taken. PK/PD research is a central aspect of the search for ARV-based prevention, and this factsheet is for advocates looking to understand some of the basic terms, aims and objectives of PK and PD studies.
FDA’s Advisory Committee Review of Daily Oral Truvada as PrEP to Reduce the Risk of HIV Infection: An advocate’s primer for public participation
This primer was developed to help advocates understand the mechanism of the US Food and Drug Administration’s external advisory committee. It was specifically developed in preparation for the US FDA review of Truvada for use as PrEP in 2012. It offers a guide to the workings of the external advisory committee (a set of outside experts who make recommendations) and ways for civil society to participate in the process.
MPT Product Development & Regulatory Issues 101
This webinar featured experts Dr. Joe Romano (NWJ Group/CAMI) and Dr. Jim Turpin (NIAID) who provided updates on the state of multipurpose prevention technologies (MPTs) research, the pipeline and potential manufacturing and regulatory pathways. MPTs are being developed to simultaneously prevent unintended pregnancy and protect against HIV and other sexually transmitted infections.Click to access the webinar slides and recording.