Women play a key role in the success of VMMC programs. The webinar discussed
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amfAR HIV Cure Summit
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Ending Epidemics Through Technology: Developing an HIV Vaccine
The status of HIV vaccines and how the U.S. will need to change its response to the global epidemic were discussed at the Center for Strategic and International Studies
Speakers include
- Dr. Anthony Fauci- Director of the National Institute of Allergy and Infectious Diseases
- Mitchell Warren- Executive Director of AVAC
- Margie McGlynn- President and CEO of International AIDS Vaccine Initiative
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The State of the HIV Prevention Union: The Road from R4P
Following HIV R4P, AVAC held a webinar focused on the “state of the prevention union” according to civil society partners who attended the meeting and/or are working on relevant issues in their countries and communities.
In the US, the “State of the Union” is the President’s address on the range of issues facing the nation. On this webinar, participants proposed, explored and debated some of the areas where prevention research and implementation is well coordinated—and places where more union is needed.
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What do women want in multipurpose technologies?
Multipurpose Prevention Technologies (MPTs) are a fast-growing area in women’s sexual and reproductive health. On November 12, AVAC and CAMI Health co-hosted a webinar: MPT Acceptability in Uganda, Nigeria and South Africa.
Webinar Materials
The webinar summarzied methods and key findings from the market research study conducted by Ipsos Healthcare, with support from the Bill & Melinda Gates Foundation, to assess the acceptability of multipurpose options among women in Uganda, Nigeria and South Africa.
The webinar discussed:
- What women in Uganda, Nigeria and South Africa shared about sexual behavior, contraceptives and HIV prevention needs—and how this information will be used to shape the MPT agenda.
What the research found about the acceptability of four potential MPTs (injectables, implants, intra-vaginal film, intra-vaginal ring). - Jeff Lucas and Moushira El-Sahn from Ipsos Healthcare summarized methods and key findings from the market research data, and Bethany Young-Holt from CAMI Health moderated the discussion.
This call was one of the latest updates in the MPT field. Here are some other resources of note:
- Two weeks ago, the journal BJOG: An international Journal of Obstetrics and Gynaecology published a suite of articles (all open access) on the future of “multipurpose” options that would provide both contraception and protection against HIV and/or other sexually transmitted infections. It is a strong series of updates related to the science and policy of new product development and an excellent overview of the state of play of this critical area of work.
- Ipsos presented an initial stage of this work last April as part of AVAC’s Research & Reality series of webinars, several of which highlighted key issues around women and the HIV prevention agenda. The archived slides and recordings are available online.
- Multiple MPT products are in the pipeline. See AVAC’s infographic, MPT Products in the Pipeline: Selected Highlights, that summarizes which MPTs are further along in testing for both sustained-release and on-demand products.
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EATG Webinar 1: Treatment as Prevention
This series of three webinars, hosted jointly by EATG and AVAC, is designed to prepare and update EATG members for a special meeting on new developments in prevention on 23-25th January 2015 in Brussels.
The first webinar addressed the latest updates on treatment as prevention. Speakers included Dr. Reuben Granich, Senior Advisor for Care and Treatment at UNAIDS, Dr. Sarah Fidler of Imperial College London, and Silvia Petretti, Deputy CEO of Positively UK.
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EATG Webinar 2: Pre-Exposure Prophylaxis
This series of three webinars, hosted jointly by EATG and AVAC, is designed to prepare and update EATG members for a special meeting on new developments in prevention on 23-25th January 2015 in Brussels. The second webinar covered pre-exposure prophylaxis (PrEP). The third webinar covered vaccines and microbicides on the 12th December.
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CROI 2015
At the Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, new data on oral PrEP and vaginal tenofovir microbicide gel emerged that have implications for HIV prevention worldwide. Read on for a summary of the news.
Three oral PrEP trials presented at CROI provided additional evidence for use of the pill Truvada (TDF/FTC) for prevention. All three trials had very high rates of consistent use and very high rates of protection against HIV infection, specifically:
- The Partners Demonstration Project among discordant heterosexual couples (where one partner is HIV-positive and one is not) in Kenya and Uganda showed that a program that delivers both PrEP for HIV-negative partners and/or antiretroviral treatment (ART) for HIV-positive partners reduced the risk of HIV infection by 96 percent. These results highlight the potential impact of combining PrEP and ARV treatment to slow the HIV epidemic.
- The PROUD Study among high risk men who have sex with men (MSM) in the UK showed that daily oral PrEP reduced the risk of HIV infection by 86 percent when delivered in existing public health clinics.
- IPERGAY, a French study, was the first to examine the efficacy of “event-driven” PrEP – in this case, a three-day dosing strategy involving four pills around the time of sex – among high risk MSM who reported frequent sex. Overall, PrEP reduced the risk of HIV infection by 86 percent in the trial. Based on reported pill use by men in the trial, the regimen that most participants took amounted to at least four doses a week. Previous studies of daily oral PrEP have shown that this may be enough to be protective. However, it is not clear how well the event-driven regimen would work for men who have less frequent sex than the men in the trial.
Also at CROI, researchers presented results from a trial of a tenofovir-based vaginal microbicide gel to be used before and after sex among young women in South Africa.
- FACTS 001 was a trial of a tenofovir-based vaginal microbicide gel to be used before and after sex among young women in South Africa. FACTS 001 found no effect for vaginal tenofovir gel overall in the trial. While it appeared that most of the participants used the product at some point, there was not enough correct and consistent use in the trial to provide significant levels of protection. There was a trend of modest protection among the small proportion of women in the trial who appeared to have used the product consistently. This was similar to trends seen in previous studies of tenofovir gel among women, but not enough to change the overall outcome of the trial.
AVAC will be working with partners to convene webinars and in-country discussions in a range of locations to talk through the implications of all of these data. We will announce the schedule in the coming weeks; if you have a specific question or would like support in organizing around these data, please contact us. Our recently released AVAC Report: Prevention on the Line provides background and analysis that anticipates and contextualizes these developments.
AVAC’s press release on these developments states:
“Today’s results add to a powerful body of evidence that ARV-based prevention works when it is used correctly and consistently. But they’re also a reminder that with nearly every prevention option available today, from condoms to PrEP to HIV treatment, correct and consistent use is both critically important and a real challenge.
The evidence tells us that we need a two-pronged approach. We should develop ambitious programs to roll out existing, proven options, including daily oral PrEP, around the world to those who can use them. At the same time, we must continue to develop and test newer methods that others at risk will actually want, demand and use.
There’s growing demand for daily oral PrEP, and the data suggest that there might be other ways to use this strategy that can provide benefit,” Warren said. “For the sake of clarity and impact, providers, advocates and end users need to work together to develop clear, consistent messages that explain what’s known and not known about levels of protection in the context of different types of sex and different patterns of use.
The women in the FACTS 001 trial, the youngest group to date in any ARV-based prevention trial, have contributed so much to our understanding of the challenges and complexities of HIV prevention. The data suggest that these young women truly did want a product they could use to reduce their risk, but that this particular product did not fit into the realities of their daily lives.
Researchers, advocates and donors must keep working with young women at high-risk of HIV to find products that will make sense in their lives. We know that we need a range of safe and effective options for different people at risk. It is clear that no single option can possibly for work all people all of the time.”
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Exploring the Pipeline: Lubes, Rings, Films, Fibers, and Shots 4 HIV Prevention
AIDS Foundation of Chicago’s Jim Pickett and Jessica Terlikowski, presented Project Ready, Set, PrEP Plus (RSP+), a webinar on the research and development pipeline of new HIV prevention tools. New forms of PrEP were discussed – from lubricants and gels to injections, films, fibers, rectal douches and rings.
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ICAP Grand Rounds Webinar- Hormonal Contraception and HIV
The ICAP Grand Rounds Webinar focused on hormonal contraception and HIV. Find the recording here.