P-Values

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

At P-Values, you’ll find updates, perspective, insights and information from staff and partners working on the frontlines of research, advocacy and implementation. P-value is a statistical term for the probability that a trial result is reliable and not the outcome of chance. 

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Global Health Watch: FY26 Proposed Budget Cuts, New FDA Leadership, WHO + UNAIDS and more

This week the proposed US 2026 budget was released by the White House and would slash funding across the entire federal government, gutting NIH and other agencies in the Department of Health and Human Services, and further reduce foreign assistance. In addition, a hostile critic of the US FDA is appointed to lead its Center for Biologics Evaluation and Research, which oversees vaccines amongst other things. Also, the UN is looking at significant cost-cutting, with UNAIDS looking to shed more than half its staff, along with reports of possibly folding it into WHO.

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Global Health Watch: Further Funding Cuts and “America First” Policies for Research Expand Threats to Global Health

The threats and actions to decimate US biomedical research and global health continued this week as the world marked 100 days of the new administration. A proposed $9.3 billion rescission package would codify unprecedented cuts to NIH, USAID, and global health programs. At the same time, a draft NIH policy may halt funding for research outside the US threatening thousands of global collaborations.

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Research Matters – Resources to Protect Research Funding 

For more than 30 years, AVAC and partners have worked to protect the infrastructure and funding that drives lifesaving HIV and biomedical research. Today, that mission is more urgent than ever. Funding from the National Institutes of Health (NIH) fuels innovation, drives the economy, and saves lives. Cuts to this support will make America—and the world—poorer, sicker, and less prepared for future health threats.

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Global Health Watch: FY26 Proposed Budget Cuts, New FDA Leadership, WHO + UNAIDS and more

This week the proposed US 2026 budget was released by the White House and would slash funding across the entire federal government, gutting NIH and other agencies in the Department of Health and Human Services, and further reduce foreign assistance. In addition, a hostile critic of the US FDA is appointed to lead its Center for Biologics Evaluation and Research, which oversees vaccines amongst other things. Also, the UN is looking at significant cost-cutting, with UNAIDS looking to shed more than half its staff, along with reports of possibly folding it into WHO.

May 2025

Global Health Watch: Further Funding Cuts and “America First” Policies for Research Expand Threats to Global Health

The threats and actions to decimate US biomedical research and global health continued this week as the world marked 100 days of the new administration. A proposed $9.3 billion rescission package would codify unprecedented cuts to NIH, USAID, and global health programs. At the same time, a draft NIH policy may halt funding for research outside the US threatening thousands of global collaborations.

May 2025

Research Matters – Resources to Protect Research Funding 

For more than 30 years, AVAC and partners have worked to protect the infrastructure and funding that drives lifesaving HIV and biomedical research. Today, that mission is more urgent than ever. Funding from the National Institutes of Health (NIH) fuels innovation, drives the economy, and saves lives. Cuts to this support will make America—and the world—poorer, sicker, and less prepared for future health threats.

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April 2025

Global Health Watch: PEPFAR Downgraded, PrEP Access Threatened, and State Dept Reorganized

This week saw a significant reorganization of the State Department and a delay in the foreign assistance “review process”. There were also new threats to PrEP programs, critical HIV services and health systems, and research in South Africa. Read on for key developments, implications, and resources for action.

April 2025

Global Health Watch: Leadership in Flux, Further Cuts to Foreign Aid, a Pandemic Accord

Just three months since the US presidential inauguration, and still more developments affecting the future of HIV prevention, global health leadership, and pandemic preparedness. From African women leaders demanding action to save HIV prevention, to escalating US foreign aid cuts and the fragile progress of WHO’s Pandemic Agreement, this issue break down what advocates need to know now.

April 2025

Despite USG Global Health Collapse, Here Are Several Data Trackers To Support Your Advocacy

With the collapse in support from the US Presidential administration in global health, data sources tracking the HIV response have been lost, from HIV incidence and prevalence to PrEP uptake and disparities among key populations and regions of the world.

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April 2025

Global Health Watch: Tariffs, NIH Cuts, Black-led HIV Research Agenda & PEPFAR’s Legacy

This week brought major developments for global health: new tariffs on pharmaceuticals are pending, a court blocks the cap on NIH indirect costs, and worries a leadership vacuum at the CDC is a cause for yet more concern. Amid the chaos, advocates rallied—defending PEPFAR’s legacy in Congress and launching a national Black-centered, Black-led HIV research agenda.

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April 2025

A Fight for Global Health and Justice: An update on AVAC vs. US State Department

Just two months ago, AVAC led other organizations to sue the US government including the President, the US State Department and USAID, seeking emergency relief from an Executive Order that inhumanely froze all funding for foreign assistance. This case may well help to determine the future of foreign assistance, executive overreach, and the role of evidence, facts, and values in US policy. 

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April 2025

Global Health Watch: CDC, NIH, FDA Hit Hard as HHS Begins Workforce Reductions

This week’s issue covers drastic cuts across the US Department of Health and Human Services (HHS), where a dramatic 20% downsizing effort is underway. The ripple effects are vast—gutting HIV prevention, infectious disease research, and vaccine development, while threatening the stability and viability of the workforce that sustains US public health and biomedical research.

April 2025

AVAC Condemns HHS Mass Layoffs

AVAC condemns the US administration’s ongoing reduction in force of the US Department of Health and Human Services, which oversees 13 agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration and the National Institutes of Health.

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April 2025

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P-Values Blog

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

Advocates Network

AVAC’s email list for organization and individuals interested in timely updates and critical perspectives on developments in biomedical HIV prevention.

Weekly News Digest

A comprehensive round-up of HIV prevention media coverage and scientific publications.

PxPulse

Each month this podcast uses interviews, discussion and first-person reflections to explore vital topics confronting the field of HIV prevention research.

PxWire

PxWire is AVAC’s quarterly update on biomedical HIV prevention. Each issue highlights key developments, challenges and opportunities, and features a centerspread infographic that provides a visual tool for framing these issues.

Pandemic Watch

Pandemic Watch is a curated news digest on the latest pandemic prevention, preparedness, and response (PPPR) news and resources.

Press Releases

A collection of official statements from AVAC.

AVAC in the News

Media clippings featuring AVAC, its staff and close partners in the news media.