Microbicide Products Currently in Clinical Trials

This graphic from AVAC’s Microbicides by the Numbers one-pager shows the different products currently being studied and how advanced the research is.

Global collaboration supports lubricant advocacy projects in Africa

AVAC, amfar, COC Netherlands and International Rectal Microbicide Advocates (IRMA) are pleased to announce seven Global Lube Access Mobilisation (GLAM) awards to projects in Africa.

GLAM, an initiative of IRMA’s Project ARM (Africa for Rectal Microbicides) in collaboration with amfAR, AVAC, and COC Netherlands, promotes advocacy in support of increased access to safe, condom-compatible lubricants for all Africans who engage in anal and vaginal intercourse, including GMT (gay men and other men who have sex with men, and transgender individuals) and heterosexual men and women.

In response to a request for proposals widely disseminated in February 2014, GLAM partners received 36 proposals representing 17 African countries (Botswana, Cameroun, Côte d’Ivoire, Democratic Republic of Congo, Ghana, Kenya, Lesotho, Malawi, Namibia, Nigeria, Rwanda, South Africa, Tanzania, Togo, Uganda, Zambia and Zimbabwe). A diverse team of 20 advocates and public health professionals with an interest in lubricant access in Africa (from Nigeria, Uganda, Kenya, Zambia, Liberia, South Africa, Rwanda, Benin, Canada, Netherlands and the United States) reviewed the proposals.

Seven projects were selected for funding. These projects began in early July 2014 and will complete their efforts in December 2014. Following is a list of these projects.

Alternatives Cameroun (Douala, Cameroun)
Working in collaboration with other organizations in Douala and Yaoundé, Alternatives Cameroun plans to organize meetings and workshops with health officials and other HIV stakeholders in the country. The meetings and workshops will underscore the importance of providing safe, condom-compatible lubricant as part of comprehensive HIV and STI prevention programming. These activities support the ultimate goal of developing and securing a channel for the distribution of safe, condom-compatible lubricant throughout Cameroun.

Centre for Popular Education and Human Rights (Accra, Ghana)
Centre for Popular Education and Human Rights (CEPEHRG) will campaign to increase access, availability, and use of safe, affordable, condom-compatible lubricant by all who engage in sexual intercourse in Ghana, with special attention given to the LGBT community. The group will call for the inclusion of condom-compatible lubricant in the national essential drug list. Educational and social marketing efforts will take place at the community outreach level and through CEPEHRG’s national advocacy work.

Centre Stage Media Arts Foundation (Bulawayo, Zimbabwe)
Centre Stage Media Arts Foundation (CSMA) will convene policy advisory seminars to engage stakeholders from the Ministry of Health, legislators and members of civil society in support of three goals. One, integrate access to safe, condom-compatible lubricant in the Zimbabwe National HIV/AIDS Strategic Plan. Two, advocate for inclusion of lube as a line item in the national HIV prevention budget. Three, campaign for policy and program changes to allow for the distribution of lube through the same public health distribution channels that condoms are distributed through. A policy brief on the integration of lube access into national HIV prevention policies and programs will be produced. Traditional and social media will be utilized.

Community Health Education Services & Advocacy (Dar es Salaam, Tanzania)
Securing government leadership and commitment to amend the national condom policy and include the provision of safe, condom-compatible lubricant in public health facilities is the chief goal of Community Health Education Services & Advocacy (CHESA). The group will work to build multi-sectorial awareness of the importance of lubricant and will engage the Minister of Health and Social Welfare, health care practitioners, community based organizations, as well as members of the GMT community. The public health message will be “Condom Compatible Lubricant Reduces New HIV Infections.”

Men Against AIDS Youth Group (Kisumu, Kenya)
Men Against AIDS Youth Group (MAAYGO) seeks to increase access to safe, condom-compatible lubricants through several methods. The group will conduct a needs assessment and implement a targeted advocacy campaign in Kisumu County for the GMT community, health care workers, and policy makers. Educational workshops will be conducted with the goal of developing a cadre of lube access advocates who will work to improve government policies and programs. A print/social marketing campaign highlighting the importance of lubricant access in HIV/STI prevention programming will be launched.

New HIV Vaccine and Microbicide Advocacy Society (Lagos, Nigeria)
The strategy New HIV Vaccine and Microbicide Advocacy Society (NHVMAS) will take to improve lubricant access in Nigeria will be to create public demand for these important products for both men and women. Advocacy will be conducted at the state and national levels to promote government investment in lube access. NHVMAS will utilize its listserv, engage the media, and conduct trainings to enhance community awareness of the importance of safe, condom-compatible lubricant in HIV/STI prevention programming.

Partners in Health Research and Development (Thika, Kenya)
The work of Partners in Health Research and Development (PHRD) will seek to improve knowledge of and access to condoms and safe, condom-compatible lubricant among key populations in Kenya. In addition, the group will undertake actions in support of the establishment of a sustainable condom and lubricant delivery system. Sensitisation sessions will be conducted for stakeholders including HIV prevention advocates, civil society coalitions, policy makers, government officials, donors, condom distributors and the media. The inclusion of safe, condom-compatible lubricant in the National Strategic Plan is one of the project’s key projected milestones.

Related materials:

Click here for the GLAM Toolkit in English in French.

The GLAM initiative supported three African projects in 2013. Click here for a GLAM PowerPoint presentation that includes information on these projects.

Click here to access the Project ARM report, On the Map: Ensuring Africa’s Place in Rectal Microbicide Research and Advocacy, published in 2012.

Creating a Prevention Agenda for Women: AVAC/CHANGE meeting for coordinated global advocacy

This report, released by CHANGE and cosponsored by AVAC, summarizes the key recommendations related to integration of HIV and family planning services, how to best move forward in the context of uncertainty about whether some hormonal contraceptives (HC) increase HIV risk, and how to advance “method mix”—a wider array of contraceptive choices for women everywhere.

HIV Prevention Research & Development Investment in 2013: In a changing global development, economic and human rights landscape

This annual accounting of funding for biomedical HIV prevention research tracks trends and identifies gaps in investment. The report shows that investment in HIV prevention research fell 4 percent in 2013, due to a combination of factors including declining investments by the United States and European donors, changes in the international development landscape and changes in the pipeline of HIV prevention products being tested.

From the Booty’s Point of View: Using perceptibility data to inform rectal microbicide development

Rectal microbicide development has made strides in recent years, but, as with vaginal microbicides, adherence remains a concern for product developers.

There are two “P” words we have always loved – pleasure and prevention.

Perceptibility is a new strategy for evaluating what products feel like and how they “behave” in the body (in the booty as well!), during insertion, everyday activities, and, of course, during sex. The hope is that, by understanding how product characteristics impact how they are felt and understood by potential users, we can better design products for pleasure and prevention.

Join IRMA, AVAC, and our expert presenter, the wonderful Kate Morrow, who will explain the third ‘P” word, perceptibility. Kate will tell us why it is so crucial to both pleasure and HIV prevention, how the perceptibility process works, and how it will help create rectal microbicide products that people actually want to put in their booties, products that will inspire people to wait in line to get them…

July 17, 10am ET
Register here.

Click here to determine the time in your location and you will be able to download Kate’s slides in advance of the webinar by visiting IRMA’s website.

The webinar will be recorded, and an audio and flash version will be made available to everyone after the webinar. Many thanks to AVAC for helping IRMA host this call.

USAID funding opportunity: Annual program statement (APS) for microbicide research, development, and introduction, round 3

This APS will supports the creative research and other innovative activities now essential to advance potential microbicides toward regulatory approval and then successfully introduce them into delivery programs. Additional detail and information on application submission can be found at http://www.grants.gov/web/grants/search-grants.html and searching for Funding Opportunity Number APS-OAA-14-000076. Questions can be sent to Petrina Williams, Agreement Specialist, at pwilliams@usaid.gov and Sallie MacElrath, Agreement Officer, at smcelrath@usaid.gov by COB June 19, 2014.
 

When do you stop an HIV prevention trial for futility? A primer for HIV prevention advocates

This fact sheet looks at why trials are stopped early for “futility.” What does this mean, when is such a recommendation made and how does it affect other ongoing trials?

HIV Prevention Europe Webinars: Rectal microbicides

The seventh webinar in our series addressing a range of topics in HIV prevention research, hosted jointly by NAM and AVAC, focused on rectal microbicides. Speakers included: Ian McGowan, University of Pittsburgh; Carolina Herrera, Imperial College; Alex Carballo-Dieguez, Columbia University; and Marc-André LeBlanc, IRMA.

The presentation was followed by a Q&A session. Click here for slides and audio from the webinar.

What Do Women Want in HIV Prevention?

For the past two decades, the HIV prevention research field has been on the hunt for options that women can use to reduce their risk of HIV, Up until recently, there have been few options other than the female condom. But in the past few years, a range of trial results have given new insights into strategies that could change the lives of women and men around the world. Some of these trials, including studies of oral tenofovir-based pre-exposure prophylaxis, or PrEP, and the microbicide tenofovir gel have found high levels of protection in some study populations—and low or no protection in other studies of the same products. The difference? In some studies, women used the products on a regular basis. In others, they didn’t.

PrEP and tenofovir gel only protect if used consistently and correctly. So do the low adherence data mean that women don’t want, or won’t use these products in the real world—not at all. In fact, the research world is still exploring what impacts women’s decisions about adherence in clinical trials. In the process, they’re uncovering key questions that less about how women view a given product, and more about how women view research itself. AVAC and its partners are dedicated to informing this evolving conversation with views from women and men who are impacted by and asked to participate in clinical trials. We’re doing this in many ways, including ongoing country-level work focused on preparing for the results of ongoing clinical trials; in-depth exploration of the issue in our most recent AVAC Report; and a recent webinar from our “Research and Reality” series that focused on adherence, women’s product preferences and the future of HIV prevention trials in women.

Have an idea about what women want—or don’t want? Have a question? Let us know!

Rectal Microbicides Video Facilitator’s Guide

This guide is meant to be used as a preparation tool for people leading community discussions, workshops, or recruitment sessions who will be showing the educational video. Background information on rectal microbicide research and the clinical trial process is included in the guide.