From the People’s Research Agenda, this graphic tracks the pipeline of potential new HIV prevention options across broadly neutralizing antibodies, preventive vaccines, pre-exposure prophylaxis, and multipurpose technologies.
HIV Prevention Pipeline: Products to Watch
People’s Research Agenda 2025 Update Summary Table
The People’s Research Agenda sets out a people-centered framework for equitable and accelerated R&D and product introduction. It tracks the science, shows where investments align—or fail to align—with community-defined priorities, and spotlights critical gaps in the pipeline of prevention options needed to meet the diverse realities of all populations. View this summary table or see the full report and dashboard.
AVAC Infographics for INTEREST 2026
For those presenting at INTEREST (as well as anyone interested in tracking the field), AVAC’s latest infographics on HIV R&D and the delivery pipeline, the current landscape of prevention options are available in an easy-to-use slide format—including lenacapavir for HIV PrEP (LEN) volume commitments, and the impact of US funding cuts with new data from PEPFAR. We hope these are useful for presentations and discussions at the conference and beyond.
We constantly update these graphics, so check back for updates. The latest version of the deck will be available here.
People’s Research Agenda
2025 Update
The People’s Research Agenda sets out a people-centered framework for equitable and accelerated R&D and product introduction. It tracks the science, shows where investments align—or fail to align—with community-defined priorities, and spotlights critical gaps in the pipeline of prevention options needed to meet the diverse realities of all populations.
At A Glance: The MPT R&D Pipeline
This graphic shows the status of products in development.
People’s Research Agenda Pipeline Tracker
This tracker provides details on key HIV prevention trials to watch. It is updated on a quarterly and ad-hoc basis as developments occur.
If you would like to share additional information or corrections, please email Breanne at [email protected]. For more, visit the People’s Research Agenda.
Spotlight on MPTs Addressing STIs
This graphic outlines the development journey of multipurpose technologies (MPTs) that guard against STIs, including HIV, while also preventing pregnancy. It tracks the advancement of various potential products through different trial stages, emphasizing their combined protective roles.
Avac Event
Introducing the Dual Prevention Pill: Lessons Learned and What’s Next for Regulatory, Research, and Rollout
This webinar has been cancelled because funding was pulled by the new US administration. Follow critical developments in US policies and their impact on global health via our new newsletter. Learn more here.
Join the IMPT and guest speakers from AVAC and Population Council for a discussion on the dual prevention pill (DPP)—a single pill that combines oral pre-exposure prophylaxis (PrEP) and oral contraception (OC) to prevent HIV and pregnancy. If approved, the DPP will be the first multi-purpose prevention technology (MPT) to be marketed since condoms.
The discussion will include real-time learnings to inform the broader MPT field on the DPP’s regulatory approval process, acceptability study results in South Africa and Zimbabwe, implementation updates, and lessons learned.
There will be a Q&A session following the presentations.
AVAC’s Guide to HIVR4P 2024 in Lima
We are looking ahead to the biennial HIV Research for Prevention 2024 conference in Lima, Peru next week, 6-10 October. HIVR4P is a space where biomedical HIV prevention research, policy and programs takes center stage. Whether you’ll be in Lima or are following from afar, AVAC will keep you connected!
Read on for information on AVAC sessions, a sortable roadmap, the Advocates’ Corner (open all week) and more!
Resources
- Use AVAC’s Prevention Roadmap of conference sessions and satellites to find what interests you the most. You can download it as a sortable spreadsheet or PDF.
- Advocates’ Corner: If you plan to be in Lima, be sure to join us and our CASPR partners at the Advocates’ Corner to take the conversations and themes deeper. The Advocates’ Corner will be open throughout the conference hosting a program of activities along with materials displays and opportunities for informal networking. Be sure to check the events page for updates on programming.
- AVAC’s Coverage: From the latest news on injectable lenacapavir, to updates on the development of next generation prevention options, to the complex work of implementing the tools that exist today and all the advocacy needed to get it all done, our email dispatches to the Advocates’ Network keep you informed. Follow events in real time on Twitter at #HIVR4P2024 and Instagram.
- People’s Research Agenda: During HIVR4P, we’ll be releasing the new People’s Research Agenda, a global initiative driven by communities and advocates to define the most urgent priorities, research questions and recommendations for HIV prevention research. We hope it serves as a guide to what is – and should be – discussed at HIVR4P and beyond.
Satellites and Sessions Featuring AVAC and Partners
Sunday, 6 October
- Satellite: Creating a Menu of Options: Early R&D of HIV prevention products for women, the MATRIX way, 08:30 – 10:00
- Satellite: The Continued Relevance of HIV Vaccines in the Age of Long-Acting Antiretrovirals: Insights from India and Sub-Saharan Africa, 10:30 – 12:00
- Satellite: Enhancing service providers’ engagement in PrEP delivery, uptake, and retention in Latin America & the Caribbean, 10:30 – 11:30
- Satellite: The brightest under 30: Celebrating youth voices and promoting meaningful youth engagement in HIV prevention research, 10:30 – 12:00
- Satellite: Catalyzing Progress in the Inclusion of Pregnant and Lactating People in HIV Prevention Research, 12:30 – 14:00
- Satellite: Delivering on the promise: Defining optimal implementation strategies and service delivery packages for the Dual Prevention Pill,14:30 – 16:00
- Satellite: What’s Really Going to Work in the Lives of AGYW? Innovations in Acceptability and Mobile Health Support Interventions for HIV Prevention, 12:30 – 14:00
- Satellite: Understanding the role and power of advocates and researchers in advancing Discovery Medicine Vaccine Trials (DMVTs) and the development of Broadly Neutralizing Antibodies (bnAbs) for HIV Prevention, 16:30 – 17:30
Monday, 7 October
- Satellite: Leveraging SBR to Engage and Empower communities in HIV Prevention Research, 09:00 – 10:00
- Satellite: Manifest Choice: Enabling a future free of HIV, 10:30 – 11:30
- Satellite: Advancing Good Participatory Practices (GPP) in Research: Enhancing Community Engagement for Impact, 12:30 – 13:30
Tuesday, 8 October
- Oral abstract: The big picture: Global trends in HIV prevention, 11:00 – 12:30
AVAC’s Catherine Verde Hashim will present the abstract, Identifying global typologies of HIV PrEP implementation: an analysis of global data using PrEP-to-need ratios and PrEP distribution volumes. - Oral abstract: Novel antiretrovirals and formulations for prevention, 11:00 – 12:40
Jim Pickett will co-moderate this session which will discuss new data on islatravir and lenacapavir for PrEP, U=U and more.
- Symposium: Quo vadis: Future design and conduct of vaccine and bNAb clinical trials, 13:30 – 15:00
AVAC’s Grace Kumwenda and colleagues will discuss the viability and practicality of bNAbs as HIV prevention tools.
- Symposium: Prevention product profiles for future options, including long-acting PrEP formulations and products, 13:30 – 15:00
Moderated by Mitchell Warren, this session will discuss the issues of choice and combination products in HIV prevention, and will look at Target Product Profiles for various technologies, especially long-acting PrEP options.
Wednesday, 9 October
- Symposium: Reducing burdens and barriers to expand the use of HIV prevention options, 13:30 – 15:00
This session will explore the promise, potential and risks of using remote tools, such as telemedicine, virtual tools, apps and self-testing and the impact of other tools used to expand access and uptake of HIV prevention modalities. It will also review approaches to overcome misinformation and mistrust.
Thursday, 10 October
- Oral abstract: Policy and legal barriers to HIV services, 08:30 – 10:00
Brian Minalga of Fred Hutchinson Cancer Center will present, The transgender scorecard: ensuring representation in HIV prevention research.
- Oral abstract: Driving PrEP implementation through community engaged science, 13:00 – 14:30
Esther Nakkazi will present, Using local languages for accurate science reporting in Media Science Cafés in East and Southern Africa.
Find these resources, conference highlights and more at AVAC’s dedicated HIVR4P 2024 page. And watch this space for new opportunities to come together and shape what happens next.
Advocates’ Guide to Multipurpose Prevention Technologies (MPTs)
Multipurpose prevention technologies (MPTs) are products designed to simultaneously address more than one sexual and reproductive health concern. This advocates’ guide shows the pipeline of products in development, discusses why MPTs are needed, investment, and what advocates can do to push for MPT development and introduction.