P-Values

Discover perspectives on the latest findings, biggest challenges and most exciting successes in our collective work.

At P-Values, you’ll find updates, perspective, insights and information from staff and partners working on the frontlines of research, advocacy and implementation. P-value is a statistical term for the probability that a trial result is reliable and not the outcome of chance. 

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Global Health Watch: Tariffs, NIH Cuts, Black-led HIV Research Agenda & PEPFAR’s Legacy

This week brought major developments for global health: new tariffs on pharmaceuticals are pending, a court blocks the cap on NIH indirect costs, and worries a leadership vacuum at the CDC is a cause for yet more concern. Amid the chaos, advocates rallied—defending PEPFAR’s legacy in Congress and launching a national Black-centered, Black-led HIV research agenda.

Prevention Option:

April 2025


A Fight for Global Health and Justice: An update on AVAC vs. US State Department

Just two months ago, AVAC led other organizations to sue the US government including the President, the US State Department and USAID, seeking emergency relief from an Executive Order that inhumanely froze all funding for foreign assistance. This case may well help to determine the future of foreign assistance, executive overreach, and the role of evidence, facts, and values in US policy. 

Prevention Option:

April 2025


Global Health Watch: CDC, NIH, FDA Hit Hard as HHS Begins Workforce Reductions

This week’s issue covers drastic cuts across the US Department of Health and Human Services (HHS), where a dramatic 20% downsizing effort is underway. The ripple effects are vast—gutting HIV prevention, infectious disease research, and vaccine development, while threatening the stability and viability of the workforce that sustains US public health and biomedical research.

April 2025


AVAC Condemns HHS Mass Layoffs

AVAC condemns the US administration’s ongoing reduction in force of the US Department of Health and Human Services, which oversees 13 agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration and the National Institutes of Health.

Prevention Option:

April 2025


Global Health Watch: USAID Cuts, HHS Overhaul, PEPFAR Uncertainty & South Africa in the Crosshairs

This week we’ve seen plans to terminate thousands more USAID awards and completely overhaul the US Department of Health and Human Services, which oversees the National Institutes of Health, the CDC and the FDA. This comes as US funding for vital scientific research in South Africa faces new threats and the future of PEPFAR remains uncertain, with its reauthorization expiring this week amid shifting priorities and budget cuts.

March 2025


PrEP in the Balance

The promise of HIV prevention is just as real as it was before the new administration took office. Only now we must find a new path. To stay on track will require trust, innovation, commitment and investment. Let’s do it.

March 2025


Launch of Lancet Global Health Series

As the global research community confronts drastic cuts and extraordinary opposition to its work by the US government, the world cannot lose focus on the critical need for high-quality, impactful clinical research.

March 2025


Global Health Watch: CDC Cuts to HIV Prevention, Restructuring Foreign Aid

This newsletter examines the proposed elimination of the US CDC’s HIV prevention program, the uncertain future of foreign assistance globally, lawsuits against the aid freeze, plans to dismantle USAID, while exploring NIH grants in South Africa and the mounting repercussions on communities.

March 2025


PEPFAR: A Strategic Necessity for US Leadership and Global Health

PEPFAR and its lifesaving services have been threatened by the new US administration’s executive order freezing all foreign aid funding. While some PEPFAR programs received waivers to restart some services, many of its activities continue to be suspended indefinitely.

March 2025


Global Health Watch: Responding to new cuts, new losses and new data

This week’s issue covers the latest developments in the AVAC vs. Department of State lawsuit, NIH’s termination of vaccine hesitancy research, new data revealing the deadly impact of foreign aid cuts on HIV, and renewed calls for African-led, sustainable health funding.

March 2025


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