A visual roadmap illustrating the key stages transitioning a product from clinical trials to large-scale real-world implementation.
Moving a Product to the “Real World”
This Week at AVAC: US election, new LEN resources, STI pipeline and PrEP service delivery
As we continue to grapple with the results of the US presidential election and what this means for our work and for global health evidence- and rights-based policies and programs generally, we wanted to share a range of new tools and resources you may find helpful in your advocacy for choice, science and rights.
Injectable Lenacapavir for PrEP


Additional LEN Resources
- Report: From Clinical Trial Efficacy to Public Health Impact: A Plan for Accelerating Access to Injectable Lenacapavir for PrEP
- PxPulse Podcast Lenacapavir: The case for investing in delivering HIV prevention
- Advocates’ Guide: The Lens on LEN: The Basics on Injectable Lenacapavir as PrEP
- Graphic: An Overview of Lenacapavir for PrEP Trials
- Graphic: Moving a Product to the Real World
- Recording: Breaking New Ground: Expanding Access to Lenacapavir—Lessons from Dolutegravir and the Future of HIV Prevention
- Graphic: The Future of ARV-Based Prevention and More
- See our lenacapavir page for a full suite of resources
Webinars on the STI Pipeline, Advances in Research Ethics, and Money for the DVR and More!


In Case You Missed It

Recording / Slides / DVR Early Market Access Vehicle page

And stay tuned for a new PxPulse podcast featuring Jen Kates of KFF and AVAC’s Suraj Madoori, The Votes Are In: What’s next for the US’ role in global health and HIV prevention. The podcast hits airways November 14.
Avac Event
Understanding Anal Pleasure and Health for Clinicians, Behavioral Health Specialists, Peers & HIV Workers
Forty years into the epidemic, people are still seeking accurate, reliable information about anal play that isn’t just about HIV and STI prevention. They want to understand how to engage in ways that maximize pleasure and reduce harms beyond infectious disease. Often, they end up encountering harmful myths rather than facts, and then learn by ‘trial and error’.
This 90-minute webinar is appropriate for HIV and STI clinicians, behavioral health workers, social workers, case managers, peers and anyone else with a responsibility for delivering or referring to HIV services like treatment, PrEP, testing and support services.
Participants learned the rationale for why addressing anal pleasure and health is essential in HIV service settings as well as ways to respond to frequently asked questions, including via a new client- and worker-facing website.
Recording I Slides I Resources
Speakers included:
- Bryan Kutner, PhD, MPH, Albert Einstein College of Medicine
- Samuel Anyula Gorigo, Hoymas (Health Options for Young Men on HIV/AIDS and STIs) Kenya

PrEP Initiations in Latin America, 2019-2024
Latin American countries account for 306,000 cumulative PrEP initiations in the Global PrEP Tracker as of Q2 2024, which represent 4% of the global total. Since 2019, PrEP initiations across the region continue to increase at a steady rate, with Brazil reaching about 194,000 cumulative PrEP initiations (63% of regional total) since the inception of its National PrEP Program. Read more in PxWire.
Avac Event
True Choice in HIV Prevention Involves More than Product Options: Novel strategies in service delivery
The Choice Agenda and presenters from Brazil, Kenya, and South Africa discussed novel strategies for the delivery of HIV prevention interventions. All HIV prevention products have their “Achilles Heels.” Differentiated service delivery supports reaching a wide range of potential users and can overcome challenges with product attributes. Offering different strategies can also make the interface with health care easier and more community friendly.
Speakers:
- Ines Dourado, Universidade Federal da Bahia
- Catherine Verde Hashim, AVAC
- Catherine Martin, Wits RHI
- Katrina Ortblad, Fred Hutch
- Adriano Queiroz, City of São Paulo Municipal Health Secretariat
- Daniel Were, Jhpiego
Thanks to WHO for providing live simultaneous Ukrainian translation and to PAHO for providing live simultaneous translation in Portuguese and Spanish.
Video Recording and English Audio / Ukrainian Audio / Portuguese Audio / Spanish Audio / Slides / Resources

Avac Event
Update on Injectable Lenacapavir for PrEP
AVAC hosted a webinar focused on updates for the PURPOSE trials for injectable lenacapavir for PrEP. Gilead provided an overview of the PURPOSE 1 and 2 trial results and insight into the status of PURPOSE 3, 4, and 5. This was be an opportunity for civil society to hear from Gilead directly.

Avac Event
An Update on the STI R&D Pipeline and Investments
AVAC and Impact Global Health, previously Policy Cures Research, co-hosted a webinar on the current STI R&D pipeline. This discussion featured leading experts sharing the latest advancements in STI diagnostics and treatments, discussing their potential impact on public health and where investments stand.
Speakers:
- Mandisa Mdingi, Foundation for Professional Development, South Africa
- Cécile Ventola, Senior Technical Officer at Impact Global Health
- Birgitta Gleeson, FIND, Switzerland
Recording / Alison Footman Slides / Mandisa Mdingi Slides / Cécile Ventola Slides / Birgitta Gleeson Slides

From Clinical Trial Efficacy to Public Health Impact: A Plan for Accelerating Access to Injectable Lenacapavir for PrEP
This plan provides a broad view of all the moving parts and identifies actions and actors responsible for ensuring time is not wasted and opportunity not squandered.
AVAC’s Guide to HIVR4P 2024 in Lima
We are looking ahead to the biennial HIV Research for Prevention 2024 conference in Lima, Peru next week, 6-10 October. HIVR4P is a space where biomedical HIV prevention research, policy and programs takes center stage. Whether you’ll be in Lima or are following from afar, AVAC will keep you connected!
Read on for information on AVAC sessions, a sortable roadmap, the Advocates’ Corner (open all week) and more!

Resources
- Use AVAC’s Prevention Roadmap of conference sessions and satellites to find what interests you the most. You can download it as a sortable spreadsheet or PDF.
- Advocates’ Corner: If you plan to be in Lima, be sure to join us and our CASPR partners at the Advocates’ Corner to take the conversations and themes deeper. The Advocates’ Corner will be open throughout the conference hosting a program of activities along with materials displays and opportunities for informal networking. Be sure to check the events page for updates on programming.
- AVAC’s Coverage: From the latest news on injectable lenacapavir, to updates on the development of next generation prevention options, to the complex work of implementing the tools that exist today and all the advocacy needed to get it all done, our email dispatches to the Advocates’ Network keep you informed. Follow events in real time on Twitter at #HIVR4P2024 and Instagram.
- People’s Research Agenda: During HIVR4P, we’ll be releasing the new People’s Research Agenda, a global initiative driven by communities and advocates to define the most urgent priorities, research questions and recommendations for HIV prevention research. We hope it serves as a guide to what is – and should be – discussed at HIVR4P and beyond.

Satellites and Sessions Featuring AVAC and Partners
Sunday, 6 October
- Satellite: Creating a Menu of Options: Early R&D of HIV prevention products for women, the MATRIX way, 08:30 – 10:00
- Satellite: The Continued Relevance of HIV Vaccines in the Age of Long-Acting Antiretrovirals: Insights from India and Sub-Saharan Africa, 10:30 – 12:00
- Satellite: Enhancing service providers’ engagement in PrEP delivery, uptake, and retention in Latin America & the Caribbean, 10:30 – 11:30
- Satellite: The brightest under 30: Celebrating youth voices and promoting meaningful youth engagement in HIV prevention research, 10:30 – 12:00
- Satellite: Catalyzing Progress in the Inclusion of Pregnant and Lactating People in HIV Prevention Research, 12:30 – 14:00
- Satellite: Delivering on the promise: Defining optimal implementation strategies and service delivery packages for the Dual Prevention Pill,14:30 – 16:00
- Satellite: What’s Really Going to Work in the Lives of AGYW? Innovations in Acceptability and Mobile Health Support Interventions for HIV Prevention, 12:30 – 14:00
- Satellite: Understanding the role and power of advocates and researchers in advancing Discovery Medicine Vaccine Trials (DMVTs) and the development of Broadly Neutralizing Antibodies (bnAbs) for HIV Prevention, 16:30 – 17:30
Monday, 7 October
- Satellite: Leveraging SBR to Engage and Empower communities in HIV Prevention Research, 09:00 – 10:00
- Satellite: Manifest Choice: Enabling a future free of HIV, 10:30 – 11:30
- Satellite: Advancing Good Participatory Practices (GPP) in Research: Enhancing Community Engagement for Impact, 12:30 – 13:30
Tuesday, 8 October
- Oral abstract: The big picture: Global trends in HIV prevention, 11:00 – 12:30
AVAC’s Catherine Verde Hashim will present the abstract, Identifying global typologies of HIV PrEP implementation: an analysis of global data using PrEP-to-need ratios and PrEP distribution volumes. - Oral abstract: Novel antiretrovirals and formulations for prevention, 11:00 – 12:40
Jim Pickett will co-moderate this session which will discuss new data on islatravir and lenacapavir for PrEP, U=U and more.
- Symposium: Quo vadis: Future design and conduct of vaccine and bNAb clinical trials, 13:30 – 15:00
AVAC’s Grace Kumwenda and colleagues will discuss the viability and practicality of bNAbs as HIV prevention tools.
- Symposium: Prevention product profiles for future options, including long-acting PrEP formulations and products, 13:30 – 15:00
Moderated by Mitchell Warren, this session will discuss the issues of choice and combination products in HIV prevention, and will look at Target Product Profiles for various technologies, especially long-acting PrEP options.
Wednesday, 9 October
- Symposium: Reducing burdens and barriers to expand the use of HIV prevention options, 13:30 – 15:00
This session will explore the promise, potential and risks of using remote tools, such as telemedicine, virtual tools, apps and self-testing and the impact of other tools used to expand access and uptake of HIV prevention modalities. It will also review approaches to overcome misinformation and mistrust.
Thursday, 10 October
- Oral abstract: Policy and legal barriers to HIV services, 08:30 – 10:00
Brian Minalga of Fred Hutchinson Cancer Center will present, The transgender scorecard: ensuring representation in HIV prevention research.
- Oral abstract: Driving PrEP implementation through community engaged science, 13:00 – 14:30
Esther Nakkazi will present, Using local languages for accurate science reporting in Media Science Cafés in East and Southern Africa.
Find these resources, conference highlights and more at AVAC’s dedicated HIVR4P 2024 page. And watch this space for new opportunities to come together and shape what happens next.
Avac Event
HIVR4P 2024
The 5th HIV Research for Prevention (R4P) conference is being held in Lima, Peru from 6 to 10 October. Held every two years, HIVR4P is the only global conference to focused exclusively on biomedical HIV prevention, including AIDS vaccines, microbicides, PrEP, treatment as prevention and other approaches.
See below for conference highlights, recaps and announcements.
Conference Highlights and Recaps
- Pre-conference Highlights from HIVR4P 2024
- HIVR4P Highlights Access and Choice: Inextricably Linked
- HIVR4P Wednesday Highlights: Access Access Access
- HIVR4P Thursday Highlights: Centering Communities
Announcements

