Allocation of Non-Commercial CAB for PrEP Supply in Low- and Middle-Income Countries, 2023-2025
HIV Vaccine and Antibody Efficacy Trials to Date
This infographic provides a comprehensive overview of HIV vaccine and antibody efficacy trials. Over 20 years and 12 trials, only two positive signals have been observed.
Avac Event
Just What is Discovery Medicine? And What Does it Mean for HIV Vaccine Research?
Participants joined to gain a broad understanding of Discovery Medicine including an overview of the current landscape for HIV vaccines. We also discussed what it means for HIV vaccine research and development moving forward, with a focus on community and advocacy priorities.
Speakers:
- Dr. Betty Mwesigwa, Makerere University Walter Reed Project
- Tian Johnson, BRILLIANT HIV Vaccine Discovery Consortium
- Dr. Cathy Slack, HIV AIDS Vaccines Ethics Group
- Dr. Sandhya Vasan, Henry M. Jackson Foundation for the Advancement of Military Medicine, US Military HIV Research Program
Moderators:
- Stacey Hannah, AVAC
- Louis Shackelford, HIV Vaccine Trials Network (HVTN) & COVID-19 Prevention Network (CoVPN)
Recording / Full Slides / Resources
Avac Event
PrEP and the Role of HIV Self-Testing
HIV self-testing (HIVST) is a safe, accurate, and effective alternative to provider-administered testing that many users prefer for its convenience and confidentiality. At IAS 2023, WHO issued a new recommendation to offer HIVST for PrEP initiation and continuation as an innovative way to increase PrEP access and coverage and further simplify PrEP delivery. However, many implementers still have questions on how to effectively roll out and scale up this important self-care intervention.
On May 23, AVAC and WHO hosted a webinar to learn more about WHO guidance on use of HIVST and to hear directly from a panel of experts on their experiencing rolling out HIVST for PrEP, guidance on procurement and costing, and more.
Recording / Slides
For Us by Us: PrEP in Black America – A Master Plan for HIV Prevention in Black America
In the spirit of seeking change to ameliorate the devastating impact of HIV in Black communities through biomedical HIV prevention, Black leaders convened the “PrEP in Black America (PIBA) Summit” virtually and in person on September 13, 2022, in Atlanta, Georgia. Attendees have included Black activists, researchers, scientists, providers, and policymakers from across the country representing more than 50 organizations. Following the event, PIBA generated a report summarizing the event and key recommendations entitled, “For Us by Us: PrEP in Black America – A Master Plan for HIV Prevention in Black America.”
Read the full report, “For Us by Us: PrEP in Black America – A Master Plan for HIV Prevention in Black America” here.
The More We Know
Evolving our understanding of PrEP for cisgender women
Science and real-world experience continue to demand a re-assessment of our collective understanding of the safety and effectiveness of PrEP options for women, including oral, vaginal ring, and injectable options. For instance, a new paper in the Journal of the American Medical Association by Dr. Jeanne Marrazzo (HIV Pre-Exposure Prophylaxis with Emtricitabine and Tenofovir Disoproxil Fumarate Among Cisgender Women) challenges the notion, baked into policies, programs and “conventional wisdom”, that cisgender women need to be “super-adherers” to achieve protection utilizing oral PrEP. In this webinar, we discussed this important paper and more.
Speakers:
• Dr. Jeanne Marrazzo, National Institute of Allergy and Infectious Diseases
• Joyce Ng’ang’a, WACI Health
Moderator:
Raniyah Copeland, Equity & Impact Solutions
Materials:
Recording / Ukrainian Audio / Slides / Resources / Audio Transcript (English/Ukrainian)
Avac Event
The Importance of HPV Vaccination Among People Living with HIV
HPV vaccination prevents 6 types of cancer and genital warts, including cervical cancer. Women living with HIV are up to six times more likely to develop invasive cervical cancer than their HIV-negative peers, but HPV immunization rates among this population remain low. During World Immunization Week, AVAC and TogetHER for Health co-hosted a discussion to learn more about the science behind and implementation challenges specific to expanding access to HPV vaccination for people living with HIV.
- Mandisa Dukashe, HIV Survivors and Partners Network
- Dr. Betty Njoroge, Kenya Medical Research Institute
- Dr. Christopher Morgan, Jhpiego
This webinar was co-hosted with TogetHER for Health
Recording / Mandisa Dukashe Slides / Dr. Betty Njoroge Slides / Dr. Christopher Morgan Slides
April Webinars!
This month we will host six webinars on a wide range of important issues, including choice in HIV prevention, PrEP in cisgender women, criminalization and HIV, syphilis in the US and DoxyPEP. Scroll down for what’s coming up later this week and later this month.
The More We Know: Evolving our understanding of PrEP for cisgender women
April 5, 9:00 – 10:30 am EST
Science and real-world experience continue to demand a re-assessment of our collective understanding of the safety and effectiveness of PrEP options for women, including oral, vaginal ring, and injectable options. Join us, Jeanne Marrazzo of NIAID, Joyce Ng’ang’a of WACI Health and Raniyah Copeland of Equity & Impact Solutions for a conversation with The Choice Agenda.
Watching the Watcher: Intersections of surveillance and criminalization in HIV and reproductive health care
April 9, 10:00 – 11:30 am EST
Positive Women’s Network-USA and The Choice Agenda invite you to join us for a webinar featuring leaders in digital technology, HIV advocacy, and abortion criminalization to examine the existential threat of our ongoing blurred boundaries between public health and policing.
STI Awareness Week is April 14 – 20!
Join us for two webinars focused on syphilis and DoxyPEP. These webinars are intended for health care providers, civil society organizations, public health officials, and others working in the STI/HIV fields.
Discussing Early Results from the SEARCH Dynamic Choice Study
April 23, 10:00 – 11:30 am EST
Join AVAC and Professor Moses Kamya of Makerere University to find out why the early results of the SEARCH Dynamic Choice study were some of the most exciting to come out of CROI in 2024.
Conducted in Kenya and Uganda, the study offered oral PrEP, PEP or injectable cabotegravir to both men and women, and an option to switch products.
We Can’t End HIV in the United States Without Equitable PrEP Access: strategies for success
April 26, 1:00 – 2:30 pm EST
Join HIVMA, PrEP4All and The Choice Agenda, as we assess some of the key challenges to delivering PrEP in the United States equitably, including cost, the complexities of our health care system, and other factors that inhibit uptake amongst the most vulnerable communities. Strategies to address these challenges will be offered, with lots of time for QA, discussion and much-needed debate. Please join us!
Avac Event
We Can’t End HIV in the United States Without Equitable PrEP Access: Strategies for success
A collaboration between HIVMA, PrEP4All and The Choice Agenda, this webinar assessed some of the key challenges to delivering PrEP in the United States equitably, including cost, the complexities of our health care system, and other factors that inhibit uptake amongst the most vulnerable communities. Strategies to address these challenges were offered included a Q&A, discussion and much-needed debate.
Speakers:
• Dr. Lorraine Dean, Johns Hopkins University, Department of Epidemiology
• Dr. Rupa Patel, Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
• Dr. Patrick Sullivan, Rollins School of Public Health, Emory University
Moderator:
Dr. Greg Millet, amfAR
Recording / Slides / Resources
STIWatch Newsletter, March 2024
The first quarter of 2024 ends with new research and questions on the future directions of STI vaccines and diagnostics. The Conference on Retroviruses and Opportunistic Infections (CROI) was the setting for positive news on the potential for early use of doxycycline to prevent STIs (DoxyPEP) in real-world settings and questions about its effectiveness in cisgender women given major evidence gaps. Important discussions and debates continued around the issue of antimicrobial resistance (AMR), as the field continues to grapple with the rollout of DoxyPEP. Presentations at CROI also highlighted the need for new diagnostics for syphilis as infections continue to increase globally and the need for STI advocacy efforts to ensure these infections get the attention and funding needed to develop vaccines and diagnostics that can prevent, detect, and treat these infections!
In January, the US Centers for Disease Control and Prevention (CDC) released the STI surveillance data from 2022, which showed an increase in chlamydia and syphilis cases from 2021. Gonorrhea cases decreased between 2021 and 2022 by 9%. Alarmingly, 2022 congenital syphilis cases increased by 30% from 2021, signaling an urgent need for novel prevention, treatment, and testing methods.
In Australia, a group of researchers published a response to the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine’s October 2023 statement on the use of DoxyPEP in Australia. The authors point to the potential threat of increasing AMR and the urgent need to implement measures to monitor DoxyPEP use and its impact.
Read on for upcoming webinars, must-read resources supporting advocacy for improved funding and commitments for STI vaccines and diagnostics. Afterwards, test your knowledge with AVAC’s new STI Trivia quiz.
New Report! STIs: A Review of the 2022 Vaccine and Diagnostic R&D Pipeline and Investments
A new AVAC report tracks funding trends in vaccine and diagnostics R&D, and pipeline investments for some of the most common STIs, including chlamydia, genital herpes, gonorrhea, hepatitis B, human papillomavirus (HPV), syphilis, and trichomoniasis. The report finds that STI research remains underfunded and neglected compared to other infectious diseases. Read the report to learn more.
STI Advocacy Updates
AVAC spoke with two cervical cancer advocates, Tamika Felder and Karen Nakawala, in January as part of its cervical cancer webinar series. Felder and Nakawala are breaking taboos and saving lives by empowering people to share their stories of survivorship and senseless loss.
Felder, founder of Cervivor, Inc., was diagnosed with cervical cancer at 25, and turned her struggle into a mission, providing resources and a platform for those affected by the disease. Her impactful work and advocacy inspired Nakawala to found the Teal Sisters Foundation in 2020, following her successful treatment for cervical cancer. To learn more about Tamika and Karen, watch AVACs cervical cancer webinar. Thank you, Tamika and Karen for all that you do!
January 18 marked HPV Awareness Day. AVAC and TogetHER for Health released an updated call to action to improve HPV vaccination among people living with HIV. In total, 31 organizations signed on to this call, urging global leadership to increase access to lifesaving HPV vaccines for people living with HIV.
Upcoming Events
STI Awareness Week is April 14 – 20!
Join us for two webinars focused on syphilis and DoxyPEP. These webinars are intended for health care providers, civil society organizations, public health officials, and others working in the STI/HIV fields.
September 2024 STI Conferences
REGISTRATION IS NOW OPEN FOR TWO IMPORTANT STI CONFERENCES IN SEPTEMBER – WHICH UNFORTUNATELY ARE RUNNING CONCURRENTLY IN DIFFERENT PARTS OF THE WORLD!
The 2024 STI Prevention Conference will bring 1,200 conference attendees to Atlanta, Georgia, from September 16-19, 2024. Abstracts are being accepted until March 29.
The 25th IUSTI World Congress will take place September 17-20, 2024, in Sydney, Australia, and provide an opportunity to meet, discuss and learn about the latest research and innovation in sexual and reproductive health.
What We’re Reading and Resources
- Testing, testing: the advancing diagnostics for sexually transmitted infections. Diagnostics are urgently needed to detect STIs and this article examines several that are on the horizon. A US-Based company, Qvin is developing the Q-pad, a diagnostic menstrual pad with a removable strip to identify signs of diabetes and symptoms of high-risk human papillomavirus. Daye, a UK based gynecological start-up, launched a diagnostic product that is a tampon with the ability to screen for STIs. These advancements are exciting and serve as a reminder that advocacy is needed to ensure these products get to the people who need them.
- CARB-X Funds Visyby Medical to Develop a portable rapid diagnostic for Gonorrhea Including Antibiotic Susceptibility Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award up to US$1.8 million to biotechnology company, Visby Medical, to develop a portable rapid polymerase chain reaction (PCR) diagnostic to detect gonorrhea and its susceptibility to ciprofloxacin, a former frontline oral antibiotic that can no longer treat gonorrhea infections resistant to this medication. Funding will also support development of a test for gonorrhea, chlamydia, and trichomoniasis in men based on urine samples.
- Syphilis Complicating Pregnancy and Congenital Syphilis. This manuscript provides a review of syphilis during pregnancy and congenital syphilis. As syphilis and congenital syphilis infections continue to rise, novel approaches are needed to detect, prevent, and treat infections. Because syphilis disproportionately affects populations with limited access to healthcare, new and improved diagnostics and therapeutics will need to be embedded within a health framework that prioritizes equity to improve the diagnosis and treatment of congenital syphilis, a preventable disease.
- Near-to-patient-testing to inform targeted antibiotic use for sexually transmitted infections in a public sexual health clinic: the NEPTUNE cohort study. This study examines the effectiveness of a novel lateral flow assay for point-of-care detection of gonorrhea among people with symptoms. Lateral flow assays are tests that can detect the presence of proteins or antigens for specific infections, like COVID-19 and HIV. This test had excellent clinical sensitivity and specificity in detecting gonorrhea among male and female patients with symptoms. A test like this could provide an important tool to better detect infections in settings without direct access to laboratory testing and reduce overtreatment.
- Breaking Barriers in STI Clinical Management: Addressing Resistance Challenges and Incorporating New Diagnostic Approaches. This on-demand webinar features Dr. Van Der Pol and Dr. William Geisler who share their insights on crucial aspects of STI clinical management, focusing on resistance challenges and new diagnostic approaches.
To learn more about AVAC’s STI Program, visit STIWatch.org and avac.org/sti. Email [email protected] for questions or additional information. And to sign up for specific updates on STIs, click here.