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Cruel Ironies

We’re seeing one of the most challenging moments in HIV prevention history – and the cruelest ironies. On one side, science and advocacy are delivering unprecedented progress via injectable lenacapavir (LEN) for PrEP. On the other, the global systems meant to deliver LEN and other potential innovations are being dismantled.

Preparing for LEN

In the first year since efficacy results were reported, LEN for PrEP has achieved critical milestones in record time compared to oral PrEP, the dapivirine vaginal ring, and injectable cabotegravir. Speed, scale, and equity are still needed to deliver impact.

Global Health Watch: Zambia approves LEN, what “America First” means for global health, new documentary on impacts of foreign aid freeze

This week, Zambia joined South Africa in approving injectable lenacapavir for PrEP (LEN), marking a new era of accelerated efforts to scale-up access. At the same time, there’s sharpening analyses of the major shifts in US strategy for foreign aid and global health leadership, with deep implications for the future of funding, multilateralism, and equity.

Influencing the New USG Global Health MoUs and PEPFAR Strategy

Lenacapavir Regulatory Approval

Regulatory approvals, pending decisions, and appeals as of November 2025.

New from AVAC

This round up offers on-the-ground tools for rolling out injectable lenacapavir; updates on AVAC’s court case on foreign assistance; resources on the state of defending rights to health and inclusion for key populations; a look at AVAC’s Advocacy Navigator program; updates on DPP at ICFP; and resources for cure research and the prevention of STIs.

Navigating Change

Advocacy and HIV Cure Research Agenda

Advances over the past ten years toward an HIV cure have moved cure research from a dream to an attainable goal. The field has learned more about the power of the innate immune system through individuals who have controlled their virus, either spontaneously or post-treatment, and these insights have spurred innovation and momentum in cure research.

Years Ahead in HIV Prevention Research: Time to Market

This timeline shows the potential time points when the next-generation of HIV prevention options might find their way into new programs.

The Dual Prevention Pill Introduction Plan