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Global Health Watch: Zambia approves LEN, what “America First” means for global health, new documentary on impacts of foreign aid freeze

This week, Zambia joined South Africa in approving injectable lenacapavir for PrEP (LEN), marking a new era of accelerated efforts to scale-up access. At the same time, there’s sharpening analyses of the major shifts in US strategy for foreign aid and global health leadership, with deep implications for the future of funding, multilateralism, and equity.

Influencing the New USG Global Health MoUs and PEPFAR Strategy

Lenacapavir Regulatory Approval

Regulatory approvals, pending decisions, and appeals as of November 2025.

New from AVAC

This round up offers on-the-ground tools for rolling out injectable lenacapavir; updates on AVAC’s court case on foreign assistance; resources on the state of defending rights to health and inclusion for key populations; a look at AVAC’s Advocacy Navigator program; updates on DPP at ICFP; and resources for cure research and the prevention of STIs.

Navigating Change

Advocacy and HIV Cure Research Agenda

Advances over the past ten years toward an HIV cure have moved cure research from a dream to an attainable goal. The field has learned more about the power of the innate immune system through individuals who have controlled their virus, either spontaneously or post-treatment, and these insights have spurred innovation and momentum in cure research.

Years Ahead in HIV Prevention Research: Time to Market

This timeline shows the potential time points when the next-generation of HIV prevention options might find their way into new programs.

The Dual Prevention Pill Introduction Plan

Global Health Watch: South Africa registers LEN for PrEP, US global health MoU, EU may cut $ for Gavi + Global Fund, new Lancet SRH series

This week, South Africa became the first African nation to register injectable lenacapavir (LEN) for PrEP. The US released a draft global health “Memorandum of Understanding” (MoU) with serious omissions related to HIV prevention and community engagement; and a leaked document indicates that the European Union may cut future funding to Gavi and the Global Fund. And just as this issue was being published, The Lancet issued a new series, Innovations in Sexual and Reproductive Health.

Sexually Transmitted Infections: ‘Self-testing’ versus ‘self-collection’: the critical role of consistent language in the field of STI diagnostics

This editorial from AVAC’s Alison Footman and colleagues makes the case for precise and consistent language around self-testing and self-collection. because clarity impacts policy, expectations, and access.