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Transforming HIV Prevention in 2025

Enormous changes are underway in HIV prevention and across global health. It’s our work to vigilantly track impacts on research, development and delivery and to call out inequity, greed, misinformation, and misguided assumptions. Here are three questions advocates are asking now along with resources to support this work.

Lenacapavir Regulatory Approval

Regulatory approvals, pending decisions, and appeals as of October 2025.

Where We Are Now with LEN for PrEP

The chaos in foreign assistance programs (including discontinuation of major PrEP programs), cuts in staffing and new demands on donor commitments will make decisions on the procurement of LEN for PrEP more complex and uncertain.

Moving a Product to the Real World

To reach the UNAIDS target of 10 million PrEP users by 2025, initiations of oral PrEP alone will not be enough—and this graphic shows that the field is beginning to apply past lessons to accelerate introduction of injectable cabotegravir.

The HIV Prevention Pipeline

This graphic shows currently available options for HIV prevention, newly approved and recommended treatment, and those in development.

Innovative HIV Prevention and Treatment Keynote and Panel Discussion

Global Health Watch: Development finance, impact of foreign aid cuts + new PrEP resources to track PrEP access, pricing and the pipeline

This week major shifts in development finance make headlines as do the real-time consequences of the US cuts to foreign aid and withdrawing from the WHO. AVAC’s new issue of PxWire amplifies issues of access, equity, and accountability with an update on biomedical prevention research and rollout.

Moving the STI Research, Development and Diagnostics Agenda Forward

The global burden of STIs is staggering with more than one million treatable STIs being acquired daily, and new threats like antibiotic-resistant gonorrhea and rising syphilis cases demanding urgent action. Yet funding, research, and political attention lag far behind the need.

PxWire is Out!

This issue provides a range of maps to help orient the field on critical HIV prevention activities: the status of delivering injectable cabotegravir (CAB for PrEP); funders and countries on track for early introduction of injectable lenacapavir (LEN for PrEP); and where new Phase 3 efficacy trials testing MK-8527 as a monthly pill for PrEP are taking place.

PxWire Volume 15, Issue 4

This issue provides a range of maps to help orient the field on critical HIV prevention activities: the status of delivering injectable cabotegravir; funders and countries on track for early introduction of injectable lenacapavir; and where new Phase 3 efficacy trials testing MK-8527 are taking place.